X0303 4 2008-10-09 0 0001171662 TRIPLE-S MANAGEMENT CORP GTS 0001280190 ACCIPITER CAPITAL MANAGEMENT, LLC 666 5TH AVENUE, 35TH FLOOR NEW YORK NY 10103 0 0 1 0 0001351187 ACCIPITER LIFE SCIENCES FUND II L P 666 5TH AVENUE, 35TH FLOOR NEW YORK NY 10103 0 0 1 0 0001351046 Accipiter Life Sciences Fund II Offshore Ltd 666 5TH AVENUE, 35TH FLOOR NEW YORK NY 10103 0 0 1 0 0001351186 ACCIPITER LIFE SCIENCES FUND II QP L P 666 5TH AVENUE, 35TH FLOOR NEW YORK NY 10103 0 0 1 0 0001211729 ACCIPITER LIFE SCIENCES FUND LP 666 5TH AVENUE, 35TH FLOOR NEW YORK NY 10103 0 0 1 0 0001214706 ACCIPITER LIFE SCIENCES FUND OFFSHORE LTD 666 5TH AVENUE, 35TH FLOOR NEW YORK NY 10103 0 0 1 0 0001351609 Candens Capital LLC 666 5TH AVENUE, 35TH FLOOR NEW YORK NY 10103 0 0 1 0 0001322420 HOFFMAN GABE 666 5TH AVENUE, 35TH FLOOR NEW YORK NY 10103 0 0 1 0 Class B Common Stock, par value $1.00 per share 2008-10-10 4 P 0 10574 11.6269 A 473163 I By ALSF II, LP Class B Common Stock, par value $1.00 per share 2008-10-09 4 P 0 11800 12.3450 A 11800 I By Gabe Hoffman Class B Common Stock, par value $1.00 per share 2008-10-09 4 P 0 23200 12.9013 A 35000 I By Gabe Hoffman Class B Common Stock, par value $1.00 per share 463454 I By ALSF (Offshore), Ltd. Class B Common Stock, par value $1.00 per share 914062 I By ALSF II (Offshore), Ltd. Class B Common Stock, par value $1.00 per share 529079 I By ALSF II (QP), LP Class B Common Stock, par value $1.00 per share 462741 I By ALSF, LP Held by Accipiter Life Sciences Fund II, LP. Candens Capital, LLC, the general partner of Accipiter Life Sciences Fund II, LP and Gabe Hoffman, the managing member of Candens Capital, LLC, disclaim beneficial ownership of these securities except to the extent of their pecuniary interest therein. The range of prices for the transactions reported in this line was $11.62 to $12.51. The Reporting Person undertakes to provide full information regarding the number of shares purchased at each separate price upon request by the Commission, the issuer or a security holder of the issuer. The range of prices for the transactions reported in this line was $12.64 to $13.05. The Reporting Person undertakes to provide full information regarding the number of shares purchased at each separate price upon request by the Commission, the issuer or a security holder of the issuer. Held by Accipiter Life Sciences Fund (Offshore), Ltd. Accipiter Capital Management, LLC, the investment manager of Accipiter Life Sciences Fund (Offshore), Ltd. and Gabe Hoffman, the managing member of Accipiter Capital Management, LLC, disclaim beneficial ownership of these securities except to the extent of their pecuniary interest therein. Held by Accipiter Life Sciences Fund II (Offshore), Ltd. Accipiter Capital Management, LLC, the investment manager of Accipiter Life Sciences Fund II (Offshore), Ltd. and Gabe Hoffman, the managing member of Accipiter Capital Management, LLC, disclaim beneficial ownership of these securities except to the extent of their pecuniary interest therein. Held by Accipiter Life Sciences Fund II (QP), LP. Candens Capital, LLC, the general partner of Accipiter Life Sciences Fund II (QP), LP and Gabe Hoffman, the managing member of Candens Capital, LLC, disclaim beneficial ownership of these securities except to the extent of their pecuniary interest therein. Held by Accipiter Life Sciences Fund, LP. Candens Capital, LLC, the general partner of Accipiter Life Sciences Fund, LP and Gabe Hoffman, the managing member of Candens Capital, LLC, disclaim beneficial ownership of these securities except to the extent of their pecuniary interest therein. By: Accipiter Capital Management, LLC; By: /s/ Gabe Hoffman, Managing Member 2008-10-14 By: Accipiter Life Sciences Fund II, LP; By: Candens Capital, LLC, its General Partner; By: /s/ Gabe Hoffman, Managing Member 2008-10-14 By: Accipiter Life Sciences Fund II (Offshore), Ltd.; By: Accipiter Capital Management, LLC, its Investment Manager; By: /s/ Gabe Hoffman, Managing Member 2008-10-14 By: Accipiter Life Sciences Fund II (QP), LP; By: Candens Capital, LLC, its General Partner; By: /s/ Gabe Hoffman, Managing Member 2008-10-14 By: Accipiter Life Sciences Fund, LP; By: Candens Capital, LLC, its General Partner; By: /s/ Gabe Hoffman, Managing Member 2008-10-14 By: Accipiter Life Sciences Fund (Offshore), Ltd.; By: Accipiter Capital Management, LLC, its Investment Manager, By: /s/ Gabe Hoffman, Managing Member 2008-10-14 By: Candens Capital, LLC; By: /s/ Gabe Hoffman, Managing Member 2008-10-14 By: /s/ Gabe Hoffman 2008-10-14