<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0206</schemaVersion>

    <documentType>3</documentType>

    <periodOfReport>2022-11-21</periodOfReport>

    <noSecuritiesOwned>1</noSecuritiesOwned>

    <issuer>
        <issuerCik>0001279704</issuerCik>
        <issuerName>Cellectar Biosciences, Inc.</issuerName>
        <issuerTradingSymbol>CLRB</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001958526</rptOwnerCik>
            <rptOwnerName>Lea Darrell Shane</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O CELLECTAR BIOSCIENCES, INC.</rptOwnerStreet1>
            <rptOwnerStreet2>100 CAMPUS DRIVE</rptOwnerStreet2>
            <rptOwnerCity>FLORHAM</rptOwnerCity>
            <rptOwnerState>NJ</rptOwnerState>
            <rptOwnerZipCode>07932</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isOfficer>true</isOfficer>
            <officerTitle>Chief Commercial Officer</officerTitle>
        </reportingOwnerRelationship>
    </reportingOwner>

    <remarks>Exhibit 24 - Power of Attorney</remarks>

    <ownerSignature>
        <signatureName>/s/ Christina Blakley, Attorney-in-fact for Darrell Shane Lea</signatureName>
        <signatureDate>2022-12-15</signatureDate>
    </ownerSignature>
</ownershipDocument>
