<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0306</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2020-04-27</periodOfReport>

    <issuer>
        <issuerCik>0001758730</issuerCik>
        <issuerName>Tradeweb Markets Inc.</issuerName>
        <issuerTradingSymbol>TW</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001278872</rptOwnerCik>
            <rptOwnerName>WARSHAW ROBERT J</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>TRADEWEB MARKETS INC.</rptOwnerStreet1>
            <rptOwnerStreet2>1177 AVENUE OF THE AMERICAS</rptOwnerStreet2>
            <rptOwnerCity>NEW YORK</rptOwnerCity>
            <rptOwnerState>NY</rptOwnerState>
            <rptOwnerZipCode>10036</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isOfficer>true</isOfficer>
            <officerTitle>Chief Financial Officer</officerTitle>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Class A common stock</value>
            </securityTitle>
            <transactionDate>
                <value>2020-04-27</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>D</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>36471</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>48.79</value>
                    <footnoteId id="F1"/>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>D</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>65115</value>
                    <footnoteId id="F2"/>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
    </nonDerivativeTable>

    <footnotes>
        <footnote id="F1">This amount represents the $50.25 per-share price at which shares of the issuer's Class A common stock (the &quot;Class A Common Stock&quot;) were sold in a public offering of the Class A Common Stock, less the underwriters' discount of $1.46 per share.</footnote>
        <footnote id="F2">This amount includes (i) 24,628 unvested restricted stock units (&quot;RSUs&quot;) in respect of Class A Common Stock which are scheduled to vest on January 1, 2021, (ii) 22,004 unvested RSUs in respect of Class A Common Stock which are scheduled to vest on January 1, 2022, and (iii) 10,483 unvested RSUs in respect of Class A Common Stock which are scheduled to vest in equal installments on each of the first, second and third anniversaries of March 17, 2020, in each case subject to the reporting person's continued employment through the applicable vesting date.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>/s/ Scott Zucker, Attorney-in-Fact for Robert Warshaw</signatureName>
        <signatureDate>2020-04-28</signatureDate>
    </ownerSignature>
</ownershipDocument>
