X0306 4 2018-06-05 0 0001301501 Achaogen Inc AKAO 0001278454 DOYLE JOHN C C/O ACHAOGEN, INC. 1 TOWER PLACE SUITE 300 SOUTH SAN FRANCISCO CA 94080 1 0 0 0 Stock Option (Right to Buy) 12.07 2018-06-05 4 A 0 15000 0 A 2028-06-05 Common Stock 15000 15000 D The option vests with respect to 1/12th of the shares subject thereto on each monthly anniversary of the grant date, which vesting will accelerate in full on the date of the next annual stockholder's meeting to the extent unvested as of such date, subject to continued service through each applicable vesting date. /s/ Gary Loeb, Attorney-in-fact for John C. Doyle 2018-06-06