144 0001591033 XXXXXXXX LIVE 0001278021 MarketAxess Holdings, Inc. 001-34091 55 Hudson Yards, 15th Floor New York NY 10001 212-813-6000 William Frank Cruger, Jr. Director Common Stock J.P. Morgan Securities LLC 270 Park Avenue, 10th Floor New York NY 10017 6164 1006335 35192891 09/10/2026 NASDAQ Common Stock 08/01/2021 Compensation Issuer N 300 08/01/2021 Compensation Common Stock 06/11/2020 Compensation Issuer N 238 06/11/2020 Compensation Common Stock 05/31/2020 Compensation Issuer N 162 05/31/2020 Compensation Common Stock 12/02/2019 Compensation Issuer N 162 12/02/2019 Compensation Common Stock 05/31/2019 Compensation Issuer N 299 05/31/2019 Compensation Common Stock 11/30/2018 Compensation Issuer N 299 11/30/2018 Compensation Common Stock 05/31/2018 Compensation Issuer N 259 05/31/2018 Compensation Common Stock 11/30/2017 Compensation Issuer N 259 11/30/2017 Compensation Common Stock 05/31/2017 Compensation Issuer N 318 05/31/2017 Compensation Common Stock 11/30/2016 Compensation Issuer N 318 11/30/2016 Compensation Common Stock 05/31/2016 Compensation Issuer N 486 05/31/2016 Compensation Common Stock 11/30/2015 Compensation Issuer N 486 11/30/2015 Compensation Common Stock 05/31/2015 Compensation Issuer N 802 05/31/2015 Compensation Common Stock 11/30/2014 Compensation Issuer N 802 11/30/2014 Compensation Common Stock 05/31/2014 Compensation Issuer N 974 05/31/2014 Compensation Y 09/10/2026 /s/ J.P. Morgan Securities LLC as agent and attorney-in-fact for William Frank Cruger, Jr.