-----BEGIN PRIVACY-ENHANCED MESSAGE-----
Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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 TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB
MIC-Info: RSA-MD5,RSA,
 FOSAQMl2ZHuyf1xXZiq9Gvw+jBlBMFige2eV3eQuIMTxLH/ea3FOO31lc6jYWN1R
 JG1oaK9BsVRsrKGvx4L1Ug==

<SEC-DOCUMENT>0001209191-08-007851.txt : 20080205
<SEC-HEADER>0001209191-08-007851.hdr.sgml : 20080205
<ACCEPTANCE-DATETIME>20080205170756
ACCESSION NUMBER:		0001209191-08-007851
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20080201
FILED AS OF DATE:		20080205
DATE AS OF CHANGE:		20080205

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			McVey Richard M
		CENTRAL INDEX KEY:			0001296466

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-50670
		FILM NUMBER:		08577783

	BUSINESS ADDRESS:	
		BUSINESS PHONE:		212.813.6000

	MAIL ADDRESS:	
		STREET 1:		C/O MARKETAXESS HOLDINGS INC.
		STREET 2:		140 BROADWAY, 42ND FLOOR
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10005

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			MARKETAXESS HOLDINGS INC
		CENTRAL INDEX KEY:			0001278021
		STANDARD INDUSTRIAL CLASSIFICATION:	SECURITY BROKERS, DEALERS & FLOTATION COMPANIES [6211]
		IRS NUMBER:				522230784

	BUSINESS ADDRESS:	
		STREET 1:		140 BROADWAY 42ND FLOOR
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10005
		BUSINESS PHONE:		212-831-6000

	MAIL ADDRESS:	
		STREET 1:		140 BROADWAY 42ND FLOOR
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10005

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	MARKETAXESS HOLDING INC
		DATE OF NAME CHANGE:	20040129
</SEC-HEADER>
<DOCUMENT>
<TYPE>4
<SEQUENCE>1
<FILENAME>bny48000_mcvey4.xml
<DESCRIPTION>MAIN DOCUMENT DESCRIPTION
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0202</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2008-02-01</periodOfReport>

    <issuer>
        <issuerCik>0001278021</issuerCik>
        <issuerName>MARKETAXESS HOLDINGS INC</issuerName>
        <issuerTradingSymbol>MKTX</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001296466</rptOwnerCik>
            <rptOwnerName>McVey Richard M</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O MARKETAXESS HOLDINGS INC.</rptOwnerStreet1>
            <rptOwnerStreet2>140 BROADWAY, 42ND FLOOR</rptOwnerStreet2>
            <rptOwnerCity>NEW YORK</rptOwnerCity>
            <rptOwnerState>NY</rptOwnerState>
            <rptOwnerZipCode>10005</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>1</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle>Chairman &amp; C.E.O.</officerTitle>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock, par value $0.003 per share</value>
            </securityTitle>
            <transactionDate>
                <value>2008-02-01</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>F</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>29407</value>
                    <footnoteId id="F1"/>
                </transactionShares>
                <transactionPricePerShare>
                    <value>9.53</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>D</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>964784</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
        <nonDerivativeHolding>
            <securityTitle>
                <value>Common Stock, par value $0.003 per share</value>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>495154</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>By Trusts</value>
                    <footnoteId id="F2"/>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
    </nonDerivativeTable>

    <derivativeTable></derivativeTable>

    <footnotes>
        <footnote id="F1">Represents the surrender of shares to the Company to satisfy Mr. McVey's tax withholding obligation upon the vesting of shares of restricted stock previously granted to Mr. McVey.</footnote>
        <footnote id="F2">Represents shares held by trust for the benefit of Mr. McVey and his family members.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>/s/ Ori Solomon, as Attorney-in-Fact for Richard M. McVey</signatureName>
        <signatureDate>2008-02-05</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
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