X0306 4 2016-06-23 0 0001281895 INOTEK PHARMACEUTICALS CORP ITEK 0001277495 BOESS CARSTEN C/O INOTEK PHARMACEUTICALS CORPORATION, 91 HARTWELL AVENUE LEXINGTON MA 02421 1 0 0 0 Stock Options (Right to Buy) 7.61 2016-06-23 4 A 0 12000 0.00 A 2026-06-22 Common Stock 12000 12000 D This stock option award was issued pursuant to Inotek Pharmaceuticals Corporation's 2014 Stock Option and Incentive Plan. The option shall vest in equal quarterly installments at the end of each quarter following June 23, 2016, subject to continued service through such dates. /s/ Dale Ritter, Attorney-in-Fact for Carsten Boess 2016-06-27