X0306 4 2017-08-01 0 0000891293 CTI BIOPHARMA CORP CTIC 0001276750 KIRSKE DAVID C/O CTI BIOPHARMA CORP. 3101 WESTERN AVE., SUITE 600 SEATTLE WA 98121 0 1 0 0 See Remarks Stock Option (Right to Buy) 3.43 2017-08-01 4 A 0 25000 0.00 A 2027-08-01 Common Stock 25000 25000 D The stock options will vest over a period of one year from the grant date in twelve equal monthly installments. The grant will accelerate and fully vest should Mr. Kirske's employment be terminated by the Company without cause within the first six months after the grant date. principal financial and accounting officer /s/ Bruce J. Seeley, Attorney-in-fact for David Kirske 2017-08-03