-----BEGIN PRIVACY-ENHANCED MESSAGE----- Proc-Type: 2001,MIC-CLEAR Originator-Name: webmaster@www.sec.gov Originator-Key-Asymmetric: MFgwCgYEVQgBAQICAf8DSgAwRwJAW2sNKK9AVtBzYZmr6aGjlWyK3XmZv3dTINen TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB MIC-Info: RSA-MD5,RSA, E8dg8YE6aspjowEiL3alPzB31WyYYNThkhGvKhO6TMpkhR3NRG8Wp6DWqJ02Az5A AFq7/25gShC5JfGXVVcCKw== 0001181431-10-039694.txt : 20100802 0001181431-10-039694.hdr.sgml : 20100802 20100802204519 ACCESSION NUMBER: 0001181431-10-039694 CONFORMED SUBMISSION TYPE: 3 PUBLIC DOCUMENT COUNT: 14 CONFORMED PERIOD OF REPORT: 20100802 FILED AS OF DATE: 20100802 DATE AS OF CHANGE: 20100802 REPORTING-OWNER: OWNER DATA: COMPANY CONFORMED NAME: NASR KHALED CENTRAL INDEX KEY: 0001276600 FILING VALUES: FORM TYPE: 3 SEC ACT: 1934 Act SEC FILE NUMBER: 001-34828 FILM NUMBER: 10985494 MAIL ADDRESS: STREET 1: ONE EMBARCADERO CENTER STE 3700 CITY: SAN FRANCISCO STATE: CA ZIP: 94111 REPORTING-OWNER: OWNER DATA: COMPANY CONFORMED NAME: Ehrlich Christopher B CENTRAL INDEX KEY: 0001293973 FILING VALUES: FORM TYPE: 3 SEC ACT: 1934 Act SEC FILE NUMBER: 001-34828 FILM NUMBER: 10985496 MAIL ADDRESS: STREET 1: C/O INTERWEST PARTNERS STREET 2: 2710 SAND HILL ROAD, 2ND FLOOR CITY: MENLO PARK STATE: CA ZIP: 94025 REPORTING-OWNER: OWNER DATA: COMPANY CONFORMED NAME: Pepper Douglas A CENTRAL INDEX KEY: 0001381839 FILING VALUES: FORM TYPE: 3 SEC ACT: 1934 Act SEC FILE NUMBER: 001-34828 FILM NUMBER: 10985493 MAIL ADDRESS: STREET 1: C/O INTERWEST PARTNERS STREET 2: 2710 SAND HILL ROAD, SECOND FLOOR CITY: MENLO PARK STATE: CA ZIP: 94025 REPORTING-OWNER: OWNER DATA: COMPANY CONFORMED NAME: Grais Linda S CENTRAL INDEX KEY: 0001413306 FILING VALUES: FORM TYPE: 3 SEC ACT: 1934 Act SEC FILE NUMBER: 001-34828 FILM NUMBER: 10985495 MAIL ADDRESS: STREET 1: C/O INTERWEST PARTNERS STREET 2: 2710 SAND HILL ROAD SECOND FLOOR CITY: MENLO PARK STATE: CA ZIP: 94025 ISSUER: COMPANY DATA: COMPANY CONFORMED NAME: Trius Therapeutics Inc CENTRAL INDEX KEY: 0001356857 STANDARD INDUSTRIAL CLASSIFICATION: PHARMACEUTICAL PREPARATIONS [2834] IRS NUMBER: 201320630 STATE OF INCORPORATION: DE FISCAL YEAR END: 1231 BUSINESS ADDRESS: STREET 1: 6310 NANCY RIDGE DR SUITE 105 CITY: SAN DIEGO STATE: CA ZIP: 92121 BUSINESS PHONE: 858-452-0370 MAIL ADDRESS: STREET 1: 6310 NANCY RIDGE DR SUITE 105 CITY: SAN DIEGO STATE: CA ZIP: 92121 REPORTING-OWNER: OWNER DATA: COMPANY CONFORMED NAME: InterWest Partners IX, LP CENTRAL INDEX KEY: 0001398928 STATE OF INCORPORATION: CA FISCAL YEAR END: 1231 FILING VALUES: FORM TYPE: 3 SEC ACT: 1934 Act SEC FILE NUMBER: 001-34828 FILM NUMBER: 10985497 BUSINESS ADDRESS: STREET 1: 2710 SAND HILL ROAD STREET 2: SECOND FLOOR CITY: MENLO PARK STATE: CA ZIP: 94025 BUSINESS PHONE: 650-854-8585 MAIL ADDRESS: STREET 1: 2710 SAND HILL ROAD STREET 2: SECOND FLOOR CITY: MENLO PARK STATE: CA ZIP: 94025 3 1 rrd282035.xml FORM 3 X0203 3 2010-08-02 0 0001356857 Trius Therapeutics Inc TSRX 0001398928 InterWest Partners IX, LP 2710 SAND HILL ROAD, SECOND FLOOR MENLO PARK CA 94025 0 0 1 0 0001293973 Ehrlich Christopher B 2710 SAND HILL ROAD, SECOND FLOOR MENLO PARK CA 94025 0 0 0 1 Venture Member 0001413306 Grais Linda S 2710 SAND HILL ROAD, SECOND FLOOR MENLO PARK CA 94025 0 0 0 1 Venture Member 0001276600 NASR KHALED 2710 SAND HILL ROAD, SECOND FLOOR MENLO PARK CA 94025 0 0 0 1 Venture Members 0001381839 Pepper Douglas A 2710 SAND HILL ROAD, SECOND FLOOR MENLO PARK CA 94025 0 0 0 1 Venture Member Series A-2 Preferred Stock Common Stock 9090910 D Series B Preferred Stock Common Stock 4469697 D The Series A-2 Preferred Stock has no expiration date and is convertible at any time at the option of the holder and will convert upon the closing of the Issuer's initial public offering at a conversion ratio of 1 share of Common Stock for every 8.6 shares of Series A-2 Preferred Stock, for no additional consideration. The Series B Preferred Stock has no expiration date and is convertible at any time at the option of the holder and will convert upon the closing of the Issuer's initial public offering at a conversion ratio of 1 share of Common Stock for every 8.6 shares of Series B Preferred Stock, for no additional consideration. The shares are owned by InterWest Partners IX, LP ("IW9"). InterWest Management Partners IX, LLC ("IMP9") is the general partner of IW9 and has sole voting and investment control over the shares owned by IW9. Harvey B. Cash, Philip T. Gianos, W. Stephen Holmes, Gilbert H. Kliman, Arnold L. Oronsky, Thomas L. Rosch, and Michael B. Sweeney are Managing Directors of IMP9 and Bruce A. Cleveland, Christopher B. Ehrlich, Linda S. Grais, Nina Kjellson, Khaled A. Nasr, and Douglas A. Pepper are Venture Members of IMP9. Each Managing Director and Venture Member of IMP9 disclaims beneficial ownership of such shares, except to the extent of their pecuniary interest therein. Form 2 of 2 /s/ See Signatures on Exhibit 99.1 2010-08-02 EX-24.1 2 rrd252707_285176.htm POWER OF ATTORNEY rrd252707_285176.html 
                                                                    Exhibit 24.1

                                POWER OF ATTORNEY

KNOW ALL BY THESE PRESENTS:

The undersigned, Harvey B. Cash, hereby constitutes and appoints Karen A. Wilson
as his true and lawful Attorney-in-Fact, with full power in his name and on his
behalf, to take all actions and do all things necessary with respect to all
matters arising in connection with the ownership reporting requirements of the
securities laws of the United States, including the execution and delivery of
all documents in connection therewith.

The undersigned agrees to indemnify said Attorney-in-Fact against, and hold her
free and harmless from, and all loss, cost, expense, damage or liability which
she may incur or sustain as a result of any action taken by his in good faith
pursuant to this Power of Attorney.

This Power of Attorney shall remain in full force and effect until revoked in
writing by the undersigned and the authority granted herein may be relied upon
by any person until such person has actually received written notice of
revocation.

IN WITNESS WHEREOF, the undersigned has executed this Power of Attorney this
12th day of February, 1996.

                                        HARVEY B. CASH

                                        /s/ Harvey B. Cash
                                        ----------------------------------------
EX-24.2 3 rrd252707_285177.htm POWER OF ATTORNEY rrd252707_285177.html 
                                                                    Exhibit 24.2

                                POWER OF ATTORNEY

KNOW ALL BY THESE PRESENTS:

The undersigned, Philip T. Gianos, hereby constitutes and appoints Karen A.
Wilson as his true and lawful Attorney-in-Fact, with full power in his name and
on his behalf, to take all actions and do all things necessary with respect to
all matters arising in connection with the ownership reporting requirements of
the securities laws of the United States, including the execution and delivery
of all documents in connection therewith.

The undersigned agrees to indemnify said Attorney-in-Fact against, and hold her
free and harmless from, and all loss, cost, expense, damage or liability which
she may incur or sustain as a result of any action taken by his in good faith
pursuant to this Power of Attorney.

This Power of Attorney shall remain in full force and effect until revoked in
writing by the undersigned and the authority granted herein may be relied upon
by any person until such person has actually received written notice of
revocation.

IN WITNESS WHEREOF, the undersigned has executed this Power of Attorney this
28th day of May, 1996.

                                        PHILIP T. GIANOS

                                        /s/ Philip T. Gianos
                                        ----------------------------------------
EX-24.3 4 rrd252707_285178.htm POWER OF ATTORNEY rrd252707_285178.html 
                                                                    Exhibit 24.3

                                POWER OF ATTORNEY

KNOW ALL BY THESE PRESENTS:

The undersigned, W. Stephen Holmes, hereby constitutes and appoints Karen A.
Wilson as his true and lawful Attorney-in-Fact, with full power in his name and
on his behalf, to take all actions and do all things necessary with respect to
all matters arising in connection with the ownership reporting requirements of
the securities laws of the United States, including the execution and delivery
of all documents in connection therewith.

The undersigned agrees to indemnify said Attorney-in-Fact against, and hold her
free and harmless from, and all loss, cost, expense, damage or liability which
she may incur or sustain as a result of any action taken by his in good faith
pursuant to this Power of Attorney.

This Power of Attorney shall remain in full force and effect until revoked in
writing by the undersigned and the authority granted herein may be relied upon
by any person until such person has actually received written notice of
revocation.

IN WITNESS WHEREOF, the undersigned has executed this Power of Attorney this
28th day of May, 1996.

                                        W. STEPHEN HOLMES

                                        /s/ W. Stephen Holmes
                                        ----------------------------------------
EX-24.4 5 rrd252707_285179.htm POWER OF ATTORNEY rrd252707_285179.html 
                                                                    Exhibit 24.4

                                POWER OF ATTORNEY

KNOW ALL BY THESE PRESENTS:

The undersigned, Gilbert H. Kliman, hereby constitutes and appoints Karen A.
Wilson as his true and lawful Attorney-in-Fact, with full power in his name and
on his behalf, to take all actions and do all things necessary with respect to
all matters arising in connection with the ownership reporting requirements of
the securities laws of the United States, including the execution and delivery
of all documents in connection therewith.

The undersigned agrees to indemnify said Attorney-in-Fact against, and hold her
free and harmless from, and all loss, cost, expense, damage or liability which
she may incur or sustain as a result of any action taken by his in good faith
pursuant to this Power of Attorney.

This Power of Attorney shall remain in full force and effect until revoked in
writing by the undersigned and the authority granted herein may be relied upon
by any person until such person has actually received written notice of
revocation.

IN WITNESS WHEREOF, the undersigned has executed this Power of Attorney this 8th
day of September, 2000.

                                        GILBERT H. KLIMAN

                                        /s/ Gilbert H. Kliman
                                        ----------------------------------------
EX-24.5 6 rrd252707_285180.htm POWER OF ATTORNEY rrd252707_285180.html 
                                                                    Exhibit 24.5

                                POWER OF ATTORNEY

KNOW ALL BY THESE PRESENTS:

The undersigned, Arnold L. Oronsky, hereby constitutes and appoints Karen A.
Wilson as his true and lawful Attorney-in-Fact, with full power in his name and
on his behalf, to take all actions and do all things necessary with respect to
all matters arising in connection with the ownership reporting requirements of
the securities laws of the United States, including the execution and delivery
of all documents in connection therewith.

The undersigned agrees to indemnify said Attorney-in-Fact against, and hold her
free and harmless from, and all loss, cost, expense, damage or liability which
she may incur or sustain as a result of any action taken by his in good faith
pursuant to this Power of Attorney.

This Power of Attorney shall remain in full force and effect until revoked in
writing by the undersigned and the authority granted herein may be relied upon
by any person until such person has actually received written notice of
revocation.

IN WITNESS WHEREOF, the undersigned has executed this Power of Attorney this
28th day of May, 1996.

                                        ARNOLD L. ORONSKY

                                        /s/Arnold L. Oronsky
                                        ----------------------------------------
EX-24.6 7 rrd252707_285181.htm POWER OF ATTORNEY rrd252707_285181.html 
                                                                    Exhibit 24.6

                                POWER OF ATTORNEY

KNOW ALL BY THESE PRESENTS:

The undersigned, Thomas L. Rosch, hereby constitutes and appoints Karen A.
Wilson as his true and lawful Attorney-in-Fact, with full power in his name and
on his behalf, to take all actions and do all things necessary with respect to
all matters arising in connection with the ownership reporting requirements of
the securities laws of the United States, including the execution and delivery
of all documents in connection therewith.

The undersigned agrees to indemnify said Attorney-in-Fact against, and hold her
free and harmless from, and all loss, cost, expense, damage or liability which
she may incur or sustain as a result of any action taken by his in good faith
pursuant to this Power of Attorney.

This Power of Attorney shall remain in full force and effect until revoked in
writing by the undersigned and the authority granted herein may be relied upon
by any person until such person has actually received written notice of
revocation.

IN WITNESS WHEREOF, the undersigned has executed this Power of Attorney this
14th day of December, 2000.


                                        THOMAS L. ROSCH

                                        /s/ Thomas L. Rosch
                                        ----------------------------------------
EX-24.7 8 rrd252707_285182.htm POWER OF ATTORNEY rrd252707_285182.html 
                                                                    Exhibit 24.7

                                POWER OF ATTORNEY

KNOW ALL BY THESE PRESENTS:

The undersigned, Michael B. Sweeney, hereby constitutes and appoints Karen A.
Wilson as his true and lawful Attorney-in-Fact, with full power in his name and
on his behalf, to take all actions and do all things necessary with respect to
all matters arising in connection with the ownership reporting requirements of
the securities laws of the United States, including the execution and delivery
of all documents in connection therewith.

The undersigned agrees to indemnify said Attorney-in-Fact against, and hold her
free and harmless from, and all loss, cost, expense, damage or liability which
she may incur or sustain as a result of any action taken by his in good faith
pursuant to this Power of Attorney.

This Power of Attorney shall remain in full force and effect until revoked in
writing by the undersigned and the authority granted herein may be relied upon
by any person until such person has actually received written notice of
revocation.

IN WITNESS WHEREOF, the undersigned has executed this Power of Attorney this
22nd day of October, 2003.

                                        MICHAEL B. SWEENEY

                                        /s/ Michael B. Sweeney
                                        ----------------------------------------
EX-24.8 9 rrd252707_285183.htm POWER OF ATTORNEY rrd252707_285183.html 
                                                                    Exhibit 24.8

                                POWER OF ATTORNEY

KNOW ALL BY THESE PRESENTS:

The undersigned, Bruce A. Cleveland, hereby constitutes and appoints Karen A.
Wilson as his true and lawful Attorney-in-Fact, with full power in his name and
on his behalf, to take all actions and do all things necessary with respect to
all matters arising in connection with the ownership reporting requirements of
the securities laws of the United States, including the execution and delivery
of all documents in connection therewith.

The undersigned agrees to indemnify said Attorney-in-Fact against, and hold her
free and harmless from, and all loss, cost, expense, damage or liability which
she may incur or sustain as a result of any action taken by his in good faith
pursuant to this Power of Attorney.

This Power of Attorney shall remain in full force and effect until revoked in
writing by the undersigned and the authority granted herein may be relied upon
by any person until such person has actually received written notice of
revocation.

IN WITNESS WHEREOF, the undersigned has executed this Power of Attorney this
31st day of May, 2007.

                                        BRUCE A. CLEVELAND

                                        /s/ Bruce A. Cleveland
                                        ----------------------------------------
EX-24.9 10 rrd252707_285196.htm POWER OF ATTORNEY rrd252707_285196.html 
                                                                    Exhibit 24.9

                                POWER OF ATTORNEY

KNOW ALL BY THESE PRESENTS:

The undersigned, Christopher B. Ehrlich, hereby constitutes and appoints Karen
A. Wilson as his true and lawful Attorney-in-Fact, with full power in his name
and on his behalf, to take all actions and do all things necessary with respect
to all matters arising in connection with the ownership reporting requirements
of the securities laws of the United States, including the execution and
delivery of all documents in connection therewith.

The undersigned agrees to indemnify said Attorney-in-Fact against, and hold her
free and harmless from, and all loss, cost, expense, damage or liability which
she may incur or sustain as a result of any action taken by his in good faith
pursuant to this Power of Attorney.

This Power of Attorney shall remain in full force and effect until revoked in
writing by the undersigned and the authority granted herein may be relied upon
by any person until such person has actually received written notice of
revocation.

IN WITNESS WHEREOF, the undersigned has executed this Power of Attorney this
22nd day of October, 2003.

                                        CHRISTOPHER B. EHRLICH

                                        /s/ Christopher B. Ehrlich
                                        ----------------------------------------
EX-24.10 11 rrd252707_285198.htm POWER OF ATTORNEY rrd252707_285198.html 
                                                                   Exhibit 24.10

                                POWER OF ATTORNEY

KNOW ALL BY THESE PRESENTS:

The undersigned, Linda S. Grais, hereby constitutes and appoints Karen A. Wilson
as her true and lawful Attorney-in-Fact, with full power in her name and on her
behalf, to take all actions and do all things necessary with respect to all
matters arising in connection with the ownership reporting requirements of the
securities laws of the United States, including the execution and delivery of
all documents in connection therewith.

The undersigned agrees to indemnify said Attorney-in-Fact against, and hold her
free and harmless from, and all loss, cost, expense, damage or liability which
she may incur or sustain as a result of any action taken by her in good faith
pursuant to this Power of Attorney.

This Power of Attorney shall remain in full force and effect until revoked in
writing by the undersigned and the authority granted herein may be relied upon
by any person until such person has actually received written notice of
revocation.

IN WITNESS WHEREOF, the undersigned has executed this Power of Attorney this 7th
day of November, 2007.

                                        LINDA S. GRAIS

                                        /s/ Linda S. Grais
                                        ----------------------------------------
EX-24.11 12 rrd252707_285199.htm POWER OF ATTORNEY rrd252707_285199.html 
                                                                   Exhibit 24.11

                                POWER OF ATTORNEY

KNOW ALL BY THESE PRESENTS:

The undersigned, Khaled A. Nasr, hereby constitutes and appoints Karen A. Wilson
as his true and lawful Attorney-in-Fact, with full power in his name and on his
behalf, to take all actions and do all things necessary with respect to all
matters arising in connection with the ownership reporting requirements of the
securities laws of the United States, including the execution and delivery of
all documents in connection therewith.

The undersigned agrees to indemnify said Attorney-in-Fact against, and hold her
free and harmless from, and all loss, cost, expense, damage or liability which
she may incur or sustain as a result of any action taken by his in good faith
pursuant to this Power of Attorney.

This Power of Attorney shall remain in full force and effect until revoked in
writing by the undersigned and the authority granted herein may be relied upon
by any person until such person has actually received written notice of
revocation.

IN WITNESS WHEREOF, the undersigned has executed this Power of Attorney this
31st day of May, 2007.

                                        KHALED A. NASR

                                        /s/ Khaled A. Nasr
                                        ----------------------------------------
EX-24.12 13 rrd252707_285200.htm POWER OF ATTORNEY rrd252707_285200.html 
                                                                   Exhibit 24.12

                                POWER OF ATTORNEY

KNOW ALL BY THESE PRESENTS:

The undersigned, Douglas A. Pepper, hereby constitutes and appoints Karen A.
Wilson as his true and lawful Attorney-in-Fact, with full power in his name and
on his behalf, to take all actions and do all things necessary with respect to
all matters arising in connection with the ownership reporting requirements of
the securities laws of the United States, including the execution and delivery
of all documents in connection therewith.

The undersigned agrees to indemnify said Attorney-in-Fact against, and hold her
free and harmless from, and all loss, cost, expense, damage or liability which
she may incur or sustain as a result of any action taken by his in good faith
pursuant to this Power of Attorney.

This Power of Attorney shall remain in full force and effect until revoked in
writing by the undersigned and the authority granted herein may be relied upon
by any person until such person has actually received written notice of
revocation.

IN WITNESS WHEREOF, the undersigned has executed this Power of Attorney this 1st
day of June, 2007.

                                        DOUGLAS A. PEPPER

                                        /s/ Douglas A. Pepper
                                        ----------------------------------------
EX-99.1 14 rrd252707_285744.htm JOINT FILER INFORMATION rrd252707_285744.html 
                                                                                                                     Exhibit 99.1

                                                       FORM 3 JOINT FILER INFORMATION

Name of
"Reporting Persons":       InterWest Partners IX, L.P. ("IW9")
                           InterWest Management Partners IX, LLC ("IMP9")

                           Harvey B. Cash
                           Philip T. Gianos
                           W. Stephen Holmes
                           Gilbert H. Kliman
                           Arnold L. Oronsky
                           Thomas L. Rosch
                           Michael B. Sweeney
                           Bruce A. Cleveland
                           Christopher B. Ehrlich
                           Linda S. Grais
                           Khaled A. Nasr
                           Douglas A. Pepper

Address:                   2710 Sand Hill Road, Second Floor
                           Menlo Park, CA 94025

Designated Filer:          InterWest Partners IX, L.P.

Issuer and Ticker Symbol:  Trius Therapeutics, Inc. (TSRX)

Date of Event:             August 2, 2010

Each of the following is a Joint Filer with InterWest Partners IX L.P. ("IW9") and may be deemed to share indirect beneficial
ownership in the securities set forth on the attached Form 3:

InterWest Management Partners IX, LLC ("IMP9") is the general partner of IW9 and has sole voting and investment control over the
shares owned by IW9. Harvey B. Cash, Philip T. Gianos, W. Stephen Holmes, Gilbert H. Kliman, Arnold L. Oronsky, Thomas L. Rosch,
and Michael B. Sweeney are Managing Directors of IMP9 and Bruce A. Cleveland, Christopher B. Ehrlich, Linda S. Grais, Nina
Kjellson, Khaled A. Nasr, and Douglas A. Pepper are Venture Members of IMP9. Nina Kjellson, a Venture Member of IMP9 is also a
Director of the Issuer, and has filed a separate Form 3 in her own name.

All Reporting Persons disclaim beneficial ownership of shares of Trius Therapeutics, Inc. stock held by IW9, except to the extent
of their respective pecuniary interest therein. The filing of this statement shall not be deemed an admission that, for purposes
of Section 16 of the Securities Exchange Act of 1934, or otherwise, any of the Reporting Persons are the beneficial owner of all
of the equity securities covered by this statement.

Each of the Reporting Persons listed above has designated InterWest Partners IX, L.P. as its designated filer of Forms 3, 4 and 5
in accordance with Section 16(a) of the Securities Exchange Act of 1934 and the rules thereunder. Each Reporting Person has
appointed InterWest Management Partners IX, LLC as its attorney in fact for the purpose of making reports relating to transaction
in Trius Therapeutics, Inc. Common Stock.

INTERWEST MANAGEMENT PARTNERS IX, L.L.C.                     Thomas L. Rosch, an individual
                                                             By: InterWest Management Partners IX, LLC,
                                                                 as Attorney-in-Fact
By:  /s/ W. Stephen Holmes
    -----------------------
 Stephen Holmes, Managing Director                           By:   /s/ Karen A. Wilson
                                                                  ---------------------------------------
                                                                       Karen A. Wilson, Power of Attorney

INTERWEST PARTNERS IX, LP                                    Michael B. Sweeney, an individual
                                                             By: InterWest Management Partners IX, LLC,
By:    InterWest Management Partners IX, LLC                     as Attorney-in-Fact
       Its General Partner
                                                             By:   /s/ Karen A. Wilson
                                                                  ---------------------------------------
                                                                       Karen A. Wilson, Power of Attorney
By:  /s/ W. Stephen Holmes
    ------------------------------------------------
         W. Stephen Holmes, Managing Director

Harvey B. Cash, an individual                                Bruce A. Cleveland, an individual
By: InterWest Management Partners IX, LLC,                   By: InterWest Management Partners IX, LLC,
    as Attorney-in-Fact                                          as Attorney-in-Fact

By:  /s/ Karen A. Wilson                                     By:   /s/ Karen A. Wilson
    ------------------------------------------------              ---------------------------------------
         Karen A. Wilson, Power of Attorney                            Karen A. Wilson, Power of Attorney

Philip T. Gianos, an individual                              Christopher B. Ehrlich, an individual
By: InterWest Management Partners IX, LLC,                   By: InterWest Management Partners IX, LLC,
    as Attorney-in-Fact                                          as Attorney-in-Fact

By:  /s/ Karen A. Wilson                                     By:   /s/ Karen A. Wilson
    ------------------------------------------------              ---------------------------------------
         Karen A. Wilson, Power of Attorney                            Karen A. Wilson, Power of Attorney

W. Stephen Holmes, an individual                             Linda S. Grais, an individual
By: InterWest Management Partners IX, LLC,                   By: InterWest Management Partners IX, LLC,
    as Attorney-in-Fact                                          as Attorney-in-Fact

By:  /s/ Karen A. Wilson                                     By:   /s/ Karen A. Wilson
    ------------------------------------------------              ---------------------------------------
         Karen A. Wilson, Power of Attorney                            Karen A. Wilson, Power of Attorney

Gilbert H. Kliman, an individual                             Khaled A. Nasr, an individual
By: InterWest Management Partners IX, LLC,                   By: InterWest Management Partners IX, LLC,
    as Attorney-in-Fact                                          as Attorney-in-Fact

By:  /s/ Karen A. Wilson                                     By:   /s/ Karen A. Wilson
    ------------------------------------------------              ---------------------------------------
         Karen A. Wilson, Power of Attorney                            Karen A. Wilson, Power of Attorney

Arnold L. Oronsky, an individual                             Douglas A. Pepper, an individual
By: InterWest Management Partners IX, LLC,                   By: InterWest Management Partners IX, LLC,
    as Attorney-in-Fact                                          as Attorney-in-Fact

By:  /s/ Karen A. Wilson                                     By:   /s/ Karen A. Wilson
    ------------------------------------------------              ---------------------------------------
         Karen A. Wilson, Power of Attorney                            Karen A. Wilson, Power of Attorney
-----END PRIVACY-ENHANCED MESSAGE-----