The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
1LIFE HEALTHCARE INC COM 68269G107 15,826 478,700 SH   DFND 1 478,700 0 0
ABCELLERA BIOLOGICS INC COM 00288U106 15,374 698,800 SH   DFND 1 698,800 0 0
ABERDEEN EMRG MRKTS EQT INM COM 00301W105 390 43,144 SH   DFND 1 43,144 0 0
ACADIA HEALTHCARE COMPANY IN COM 00404A109 20,257 322,820 SH   DFND 1 322,820 0 0
ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102 4,670 20,591 SH   DFND 1 20,591 0 0
ALPHABET INC CAP STK CL C 02079K107 14,697 5,864 SH   DFND 1 5,864 0 0
AMAZON COM INC COM 023135106 75,979 22,086 SH   DFND 1 22,086 0 0
ANTHEM INC COM 036752103 12,876 33,725 SH   DFND 1 33,725 0 0
APELLIS PHARMACEUTICALS INC COM 03753U106 8,706 137,749 SH   DFND 1 137,749 0 0
APOLLO SR FLOATING RATE FD I COM 037636107 217 13,761 SH   DFND 1 13,761 0 0
APPLIED MATLS INC COM 038222105 11,435 80,300 SH   DFND 1 80,300 0 0
ARVINAS INC COM 04335A105 11,111 144,300 SH   DFND 1 144,300 0 0
AVEO PHARMACEUTICALS INC COM NEW 053588307 691 104,800 SH   DFND 1 104,800 0 0
BAIDU INC SPON ADR REP A 056752108 1,305 6,400 SH   DFND 1 6,400 0 0
BARINGS BDC INC COM 06759L103 11,475 1,086,626 SH   DFND 1 1,086,626 0 0
BAXTER INTL INC COM 071813109 3,896 48,400 SH   DFND 1 48,400 0 0
BILIBILI INC SPONS ADS REP Z 090040106 19,672 161,460 SH   DFND 1 161,460 0 0
BK OF AMERICA CORP COM 060505104 2,642 64,081 SH   DFND 1 64,081 0 0
BOEING CO COM 097023105 20,751 86,620 SH   DFND 1 86,620 0 0
BROOKDALE SR LIVING INC COM 112463104 9,172 1,160,999 SH   DFND 1 1,160,999 0 0
C4 THERAPEUTICS INC COM STK 12529R107 4,753 125,600 SH   DFND 1 125,600 0 0
CARNIVAL CORP UNIT 99/99/9999 143658300 44,668 1,694,540 SH   DFND 1 1,694,540 0 0
CARVANA CO CL A 146869102 40,157 133,049 SH   DFND 1 133,049 0 0
CENTER COAST BRKFLD MLP ENRG SHS BEN INT 151461209 708 53,064 SH   DFND 1 53,064 0 0
CHECKMATE PHARMACEUTICALS IN COM 162818108 9,341 1,567,326 SH   DFND 1 1,567,326 0 0
CIGNA CORP NEW COM 125523100 20,194 85,180 SH   DFND 1 85,180 0 0
CISCO SYS INC COM 17275R102 22,032 415,700 SH   DFND 1 415,700 0 0
CITIGROUP INC COM NEW 172967424 3,450 48,761 SH   DFND 1 48,761 0 0
COHEN & STEERS MLP INCOME & COM SHS 19249B106 4,039 992,467 SH   DFND 1 992,467 0 0
COMMUNITY HEALTH SYS INC NEW COM 203668108 5,588 361,888 SH   DFND 1 361,888 0 0
COMMUNITY HEALTHCARE TR INC COM 20369C106 3,308 69,700 SH   DFND 1 69,700 0 0
CORNERSTONE STRATEGIC VALUE COM 21924B302 4,652 400,700 SH   DFND 1 400,700 0 0
CORNERSTONE TOTAL RETURN FD COM 21924U300 4,462 393,100 SH   DFND 1 393,100 0 0
COUPA SOFTWARE INC COM 22266L106 20,872 79,630 SH   DFND 1 79,630 0 0
CRISPR THERAPEUTICS AG NAMEN AKT H17182108 28,034 173,167 SH   DFND 1 173,167 0 0
CRISPR THERAPEUTICS AG NAMEN AKT H17182108 39,258 242,500 SH Call DFND 1 242,500 0 0
COVETRUS INC COM 22304C100 14,450 535,200 SH   DFND 1 535,200 0 0
CROWDSTRIKE HLDGS INC CL A 22788C105 20,130 80,100 SH   DFND 1 80,100 0 0
D R HORTON INC COM 23331A109 27,988 309,700 SH   DFND 1 309,700 0 0
DBX ETF TR XTRACK HRVST CSI 233051879 5,315 131,100 SH   DFND 1 131,100 0 0
DYNATRACE INC COM NEW 268150109 18,543 317,400 SH   DFND 1 317,400 0 0
DIVERSIFIED HEALTHCARE TR COM SH BEN INT 25525P107 3,811 911,800 SH   DFND 1 911,800 0 0
EATON VANCE FLTING RATE INC COM 278279104 1,135 78,864 SH   DFND 1 78,864 0 0
EATON VANCE SHORT DURATION D COM 27828V104 845 63,700 SH   DFND 1 63,700 0 0
EATON VANCE SR FLTNG RTE TR COM 27828Q105 838 59,200 SH   DFND 1 59,200 0 0
EATON VANCE SR INCOME TR SH BEN INT 27826S103 164 24,048 SH   DFND 1 24,048 0 0
EQUITABLE HLDGS INC COM 29452E101 33,452 1,098,600 SH   DFND 1 1,098,600 0 0
EURONET WORLDWIDE INC COM 298736109 9,301 68,720 SH   DFND 1 68,720 0 0
EXXON MOBIL CORP COM 30231G102 21,113 334,700 SH   DFND 1 334,700 0 0
FACEBOOK INC CL A 30303M102 41,357 118,940 SH   DFND 1 118,940 0 0
FIRST AMERN FINL CORP COM 31847R102 59,153 948,730 SH   DFND 1 948,730 0 0
FIRST EAGLE SENIOR LOAN FUND COM NEW 32010E100 3,292 208,600 SH   DFND 1 208,600 0 0
FIVE9 INC COM 338307101 19,527 106,480 SH   DFND 1 106,480 0 0
FLEXION THERAPEUTICS INC COM 33938J106 1,752 212,900 SH   DFND 1 212,900 0 0
FRANKLIN UNVL TR SH BEN INT 355145103 534 64,535 SH   DFND 1 64,535 0 0
GABELLI EQUITY TR INC RIGHT 07/14/2021 362397218 82 700,200 SH   DFND 1 700,200 0 0
GOSSAMER BIO INC COM 38341P102 1,297 159,725 SH   DFND 1 159,725 0 0
GOSSAMER BIO INC NOTE 5.000% 6/0 38341PAA0 2,811 3,500,000 PRN   DFND 1 3,500,000 0 0
GUGGENHEIM ENHANCED EQT INCM COM 40167B100 4,599 534,102 SH   DFND 1 534,102 0 0
HERZFELD CARIBBEAN BASIN FD COM 42804T106 433 69,082 SH   DFND 1 69,082 0 0
HIGHLAND GLOBAL ALLOCATION F COM 43010T104 595 65,684 SH   DFND 1 65,684 0 0
HOLOGIC INC COM 436440101 14,640 219,420 SH   DFND 1 219,420 0 0
HUBSPOT INC COM 443573100 19,725 33,850 SH   DFND 1 33,850 0 0
HUMANA INC COM 444859102 26,187 59,150 SH   DFND 1 59,150 0 0
INTEL CORP COM 458140100 18,414 328,000 SH   DFND 1 328,000 0 0
JPMORGAN CHASE & CO COM 46625H100 1,776 11,420 SH   DFND 1 11,420 0 0
KAYNE ANDERSON NEXTGEN ENRGY COM 48661E108 873 115,300 SH   DFND 1 115,300 0 0
JAZZ PHARMACEUTICALS PLC SHS USD G50871105 24,644 138,730 SH   DFND 1 138,730 0 0
JD.COM INC SPON ADR CL A 47215P106 958 12,000 SH   DFND 1 12,000 0 0
JOHNSON & JOHNSON COM 478160104 21,449 130,200 SH   DFND 1 130,200 0 0
KURA ONCOLOGY INC COM 50127T109 529 25,361 SH   DFND 1 25,361 0 0
KYMERA THERAPEUTICS INC COM 501575104 4,879 100,600 SH   DFND 1 100,600 0 0
LAM RESEARCH CORP COM 512807108 7,506 11,535 SH   DFND 1 11,535 0 0
LENNAR CORP CL A 526057104 27,599 277,799 SH   DFND 1 277,799 0 0
LILLY ELI & CO COM 532457108 2,757 12,013 SH   DFND 1 12,013 0 0
MASTERCARD INCORPORATED CL A 57636Q104 37,743 103,381 SH   DFND 1 103,381 0 0
MILLER HOWARD HIGH INC EQTY COM SHS BEN IN 600379101 1,481 141,304 SH   DFND 1 141,304 0 0
MODERNA INC COM 60770K107 11,523 49,040 SH   DFND 1 49,040 0 0
MCKESSON CORP COM 58155Q103 32,265 168,715 SH   DFND 1 168,715 0 0
MERCK & CO INC COM 58933Y105 3,655 47,000 SH   DFND 1 47,000 0 0
MICRON TECHNOLOGY INC COM 595112103 11,047 130,000 SH   DFND 1 130,000 0 0
MICROSOFT CORP COM 594918104 51,159 188,849 SH   DFND 1 188,849 0 0
MIRATI THERAPEUTICS INC COM 60468T105 15,945 98,715 SH   DFND 1 98,715 0 0
NETEASE INC SPONSORED ADS 64110W102 983 8,525 SH   DFND 1 8,525 0 0
NEW IRELAND FD INC COM 645673104 253 20,736 SH   DFND 1 20,736 0 0
NEW ORIENTAL ED & TECHNOLOGY SPON ADR 647581107 244 29,800 SH   DFND 1 29,800 0 0
NURIX THERAPEUTICS INC COM 67080M103 4,478 168,800 SH   DFND 1 168,800 0 0
NUVEEN DIVERSIFIED DIVID & I COM 6706EP105 119 11,436 SH   DFND 1 11,436 0 0
NUVEEN FLOATING RATE INCOME COM 67072T108 477 47,614 SH   DFND 1 47,614 0 0
NUVEEN SHORT DURATION CR OPP COM 67074X107 417 27,800 SH   DFND 1 27,800 0 0
PENNYMAC FINL SVCS INC NEW COM 70932M107 60,584 981,601 SH   DFND 1 981,601 0 0
PFIZER INC COM 717081103 31,904 814,700 SH   DFND 1 814,700 0 0
PHYSICIANS RLTY TR COM 71943U104 1,736 94,000 SH   DFND 1 94,000 0 0
PIMCO DYNAMIC CR INCOME FD COM SHS 72202D106 1,247 55,700 SH   DFND 1 55,700 0 0
PINDUODUO INC SPONSORED ADS 722304102 406 3,200 SH   DFND 1 3,200 0 0
RAYTHEON TECHNOLOGIES CORP COM 75513E101 23,929 280,500 SH   DFND 1 280,500 0 0
REDWOOD TR INC COM 758075402 15,475 1,282,100 SH   DFND 1 1,282,100 0 0
REDWOOD TR INC NOTE 4.750% 8/1 758075AC9 2,008 1,978,000 PRN   DFND 1 1,978,000 0 0
REGENERON PHARMACEUTICALS COM 75886F107 31,010 55,520 SH   DFND 1 55,520 0 0
REPARE THERAPEUTICS INC COM 760273102 10,859 348,279 SH   DFND 1 348,279 0 0
RINGCENTRAL INC CL A 76680R206 26,021 89,550 SH   DFND 1 89,550 0 0
ROYAL CARIBBEAN GROUP COM V7780T103 46,482 545,047 SH   DFND 1 545,047 0 0
SABA CAPITAL INCOME & OPRNT SHARES 78518H103 4,539 963,800 SH   DFND 1 963,800 0 0
SALESFORCE COM INC COM 79466L302 19,285 78,950 SH   DFND 1 78,950 0 0
SALIENT MIDSTREAM & MLP FD SH BEN INT 79471V105 438 73,538 SH   DFND 1 73,538 0 0
SEA LTD SPONSORD ADS 81141R100 20,812 75,790 SH   DFND 1 75,790 0 0
SERVICENOW INC COM 81762P102 6,419 11,680 SH   DFND 1 11,680 0 0
TAIWAN SEMICONDUCTOR MFG LTD SPONSORED ADS 874039100 9,348 77,800 SH   DFND 1 77,800 0 0
SPECIAL OPPORTUNITIES FD INC COM 84741T104 583 38,400 SH   DFND 1 38,400 0 0
STARWOOD PPTY TR INC NOTE 4.375% 4/0 85571BAH8 11,696 10,815,000 PRN   DFND 1 10,815,000 0 0
TALARIS THERAPEUTICS INC COM 87410C104 494 33,600 SH   DFND 1 33,600 0 0
TELADOC HEALTH INC COM 87918A105 1,072 6,447 SH   DFND 1 6,447 0 0
TELADOC HEALTH INC NOTE 1.250% 6/0 87918AAF2 786 700,000 PRN   DFND 1 700,000 0 0
TEMPLETON GLOBAL INCOME FD COM 880198106 962 171,705 SH   DFND 1 171,705 0 0
THERMO FISHER SCIENTIFIC INC COM 883556102 21,232 42,087 SH   DFND 1 42,087 0 0
VENTAS INC COM 92276F100 26,433 462,930 SH   DFND 1 462,930 0 0
TRANSDIGM GROUP INC COM 893641100 45,385 70,116 SH   DFND 1 70,116 0 0
VERACYTE INC COM 92337F107 9,070 226,860 SH   DFND 1 226,860 0 0
TWILIO INC CL A 90138F102 19,367 49,135 SH   DFND 1 49,135 0 0
TWO HBRS INVT CORP NOTE 6.250% 1/1 90187BAA9 1,828 1,799,000 PRN   DFND 1 1,799,000 0 0
UBER TECHNOLOGIES INC COM 90353T100 27,170 542,100 SH   DFND 1 542,100 0 0
UNITEDHEALTH GROUP INC COM 91324P102 11,609 28,990 SH   DFND 1 28,990 0 0
UNIVERSAL HLTH SVCS INC CL B 913903100 27,329 186,635 SH   DFND 1 186,635 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100 16,030 79,500 SH Call DFND 1 79,500 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100 18,068 89,610 SH   DFND 1 89,610 0 0
VIACOMCBS INC CL B 92556H206 31,785 703,200 SH   DFND 1 703,200 0 0
VISA INC COM CL A 92826C839 30,315 129,650 SH   DFND 1 129,650 0 0
WELLTOWER INC COM 95040Q104 27,974 336,630 SH   DFND 1 336,630 0 0
YUM CHINA HLDGS INC COM 98850P109 489 7,500 SH   DFND 1 7,500 0 0
ZAI LAB LTD ADR 98887Q104 12,018 67,900 SH   DFND 1 67,900 0 0
ZIMMER BIOMET HOLDINGS INC COM 98956P102 18,710 116,340 SH   DFND 1 116,340 0 0
ZOETIS INC CL A 98978V103 13,542 72,665 SH   DFND 1 72,665 0 0