The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
1LIFE HEALTHCARE INC COM 68269G107 18,696 478,400 SH   DFND 1 478,400 0 0
21VIANET GROUP INC SPONSORED ADS A 90138A103 384 11,900 SH   DFND 1 11,900 0 0
ABBVIE INC COM 00287Y109 9,046 83,590 SH   DFND 1 83,590 0 0
ABCELLERA BIOLOGICS INC COM 00288U106 16,113 474,484 SH   DFND 1 474,484 0 0
ACADIA HEALTHCARE COMPANY IN COM 00404A109 21,216 371,300 SH   DFND 1 371,300 0 0
AGNC INVT CORP COM 00123Q104 37,797 2,255,200 SH   DFND 1 2,255,200 0 0
ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102 4,137 18,247 SH   DFND 1 18,247 0 0
ALPHABET INC CAP STK CL C 02079K107 22,887 11,064 SH   DFND 1 11,064 0 0
AMAZON COM INC COM 023135106 6,095 1,970 SH   DFND 1 1,970 0 0
ANNALY CAPITAL MANAGEMENT IN COM 035710409 48,621 5,653,600 SH   DFND 1 5,653,600 0 0
ANTHEM INC COM 036752103 26,912 74,975 SH   DFND 1 74,975 0 0
APELLIS PHARMACEUTICALS INC COM 03753U106 20,989 489,149 SH   DFND 1 489,149 0 0
APOLLO SR FLOATING RATE FD I COM 037636107 204 13,761 SH   DFND 1 13,761 0 0
APPLIED MATLS INC COM 038222105 35,045 262,310 SH   DFND 1 262,310 0 0
ARES CAPITAL CORP NOTE 3.750% 2/0 04010LAT0 3,096 3,000,000 PRN   DFND 1 3,000,000 0 0
AVEO PHARMACEUTICALS INC COM NEW 053588307 2,196 300,000 SH   DFND 1 300,000 0 0
BAIDU INC SPON ADR REP A 056752108 653 3,000 SH   DFND 1 3,000 0 0
BARINGS BDC INC COM 06759L103 12,613 1,263,826 SH   DFND 1 1,263,826 0 0
BAXTER INTL INC COM 071813109 6,005 71,200 SH   DFND 1 71,200 0 0
BILIBILI INC SPONS ADS REP Z 090040106 653 6,100 SH   DFND 1 6,100 0 0
BK OF AMERICA CORP COM 060505104 38,877 1,004,823 SH   DFND 1 1,004,823 0 0
BLACKROCK HEALTH SCIENCS TR COM SHS 09260E105 2,733 103,900 SH   DFND 1 103,900 0 0
BLACKROCK RES & COMMODITIES SHS 09257A108 490 55,287 SH   DFND 1 55,287 0 0
BOOKING HOLDINGS INC COM 09857L108 22,832 9,800 SH Call DFND 1 9,800 0 0
BOOKING HOLDINGS INC COM 09857L108 28,161 12,087 SH   DFND 1 12,087 0 0
BRANDYWINEGBL GBL INCM OPP F COM 10537L104 709 58,816 SH   DFND 1 58,816 0 0
BROADCOM INC COM 11135F101 21,968 47,380 SH   DFND 1 47,380 0 0
CALAMOS CONV OPPORTUNITIES & SH BEN INT 128117108 919 64,600 SH   DFND 1 64,600 0 0
CALAMOS LNG SHR EQT DYNAMIC COM 12812C106 1,704 84,435 SH   DFND 1 84,435 0 0
CARNIVAL CORP UNIT 99/99/9999 143658300 38,043 1,433,440 SH   DFND 1 1,433,440 0 0
CARVANA CO CL A 146869102 17,808 67,864 SH   DFND 1 67,864 0 0
CENTER COAST BRKFLD MLP ENRG SHS BEN INT 151461209 581 53,064 SH   DFND 1 53,064 0 0
CENTRAL SECS CORP COM 155123102 1,288 33,986 SH   DFND 1 33,986 0 0
CHECKMATE PHARMACEUTICALS IN COM 162818108 16,417 1,352,313 SH   DFND 1 1,352,313 0 0
CITIGROUP INC COM NEW 172967424 29,972 411,990 SH   DFND 1 411,990 0 0
COHEN & STEERS MLP INCOME & COM SHS 19249B106 2,891 903,467 SH   DFND 1 903,467 0 0
COMMUNITY HEALTHCARE TR INC COM 20369C106 14,710 318,959 SH   DFND 1 318,959 0 0
COVETRUS INC COM 22304C100 12,351 412,100 SH   DFND 1 412,100 0 0
CRISPR THERAPEUTICS AG NAMEN AKT H17182108 13,282 109,000 SH Call DFND 1 109,000 0 0
CRISPR THERAPEUTICS AG NAMEN AKT H17182108 22,783 186,977 SH   DFND 1 186,977 0 0
CROWDSTRIKE HLDGS INC CL A 22788C105 6,240 34,190 SH   DFND 1 34,190 0 0
D R HORTON INC COM 23331A109 25,533 286,500 SH   DFND 1 286,500 0 0
DBX ETF TR XTRACK HRVST CSI 233051879 5,063 131,100 SH   DFND 1 131,100 0 0
DELAWARE ENHANCED GBL DIV & COM 246060107 1,034 105,426 SH   DFND 1 105,426 0 0
DISNEY WALT CO COM 254687106 20,519 111,200 SH Call DFND 1 111,200 0 0
DISNEY WALT CO COM 254687106 26,084 141,360 SH   DFND 1 141,360 0 0
DUFF & PHELPS SLT ENGY AND M COM NEW 26433F207 589 80,070 SH   DFND 1 80,070 0 0
DYNATRACE INC COM NEW 268150109 8,817 182,780 SH   DFND 1 182,780 0 0
EATON VANCE FLTG RATE INCOM COM SHS BEN INT 278284104 2,446 150,234 SH   DFND 1 150,234 0 0
EATON VANCE FLTING RATE INC COM 278279104 277 19,664 SH   DFND 1 19,664 0 0
EATON VANCE SR INCOME TR SH BEN INT 27826S103 155 23,448 SH   DFND 1 23,448 0 0
EQUITABLE HLDGS INC COM 29452E101 35,954 1,102,200 SH   DFND 1 1,102,200 0 0
FIRST AMERN FINL CORP COM 31847R102 44,493 785,400 SH   DFND 1 785,400 0 0
FIRST EAGLE SENIOR LOAN FUND COM NEW 32010E100 876 61,100 SH   DFND 1 61,100 0 0
FIRST TR SR FLG RTE INCM FD COM 33733U108 200 16,300 SH   DFND 1 16,300 0 0
FLEXION THERAPEUTICS INC COM 33938J106 5,929 662,406 SH   DFND 1 662,406 0 0
GABELLI UTIL TR RIGHT 04/14/2021 36240A168 22 201,400 SH   DFND 1 201,400 0 0
GDS HLDGS LTD SPONSORED ADS 36165L108 288 3,552 SH   DFND 1 3,552 0 0
GOLUB CAP BDC INC COM 38173M102 12,078 826,125 SH   DFND 1 826,125 0 0
GOSSAMER BIO INC COM 38341P102 4,242 458,634 SH   DFND 1 458,634 0 0
GOSSAMER BIO INC NOTE 5.000% 6/0 38341PAA0 3,190 3,500,000 PRN   DFND 1 3,500,000 0 0
GUGGENHEIM ENHANCED EQUITY I COM 40167B100 212 29,365 SH   DFND 1 29,365 0 0
HANCOCK JOHN INVT TR TAX ADV GLB SH 41013P749 555 86,430 SH   DFND 1 86,430 0 0
HERCULES CAPITAL INC DBCV 4.375% 2/0 427096AF9 31 30,000 PRN   DFND 1 30,000 0 0
HERZFELD CARIBBEAN BASIN FD COM 42804T106 450 76,501 SH   DFND 1 76,501 0 0
HIGHLAND GLOBAL ALLOCATION F COM 43010T104 3,414 442,756 SH   DFND 1 442,756 0 0
HIGHLAND INCOME FD HIGHLAND INCOME 43010E404 2,967 267,533 SH   DFND 1 267,533 0 0
HOLOGIC INC COM 436440101 15,696 211,020 SH   DFND 1 211,020 0 0
HUMANA INC COM 444859102 26,838 64,015 SH   DFND 1 64,015 0 0
INTEL CORP COM 458140100 20,096 314,000 SH   DFND 1 314,000 0 0
INVESCO DYNAMIC CR OPPORTUNI COM 46132R104 1,320 116,100 SH   DFND 1 116,100 0 0
INVESCO QQQ TR UNIT SER 1 46090E103 367,000 1,150,000 SH Put DFND 1 1,150,000 0 0
ISHARES TR NASDAQ BIOTECH 464287556 29,254 194,300 SH Put DFND 1 194,300 0 0
JAZZ PHARMACEUTICALS PLC SHS USD G50871105 20,510 124,780 SH   DFND 1 124,780 0 0
JD.COM INC SPON ADR CL A 47215P106 1,012 12,000 SH   DFND 1 12,000 0 0
JOHNSON & JOHNSON COM 478160104 26,260 159,780 SH   DFND 1 159,780 0 0
JPMORGAN CHASE & CO COM 46625H100 26,861 176,450 SH   DFND 1 176,450 0 0
KURA ONCOLOGY INC COM 50127T109 717 25,361 SH   DFND 1 25,361 0 0
LAM RESEARCH CORP COM 512807108 26,030 43,730 SH   DFND 1 43,730 0 0
LENNAR CORP CL A 526057104 26,016 256,999 SH   DFND 1 256,999 0 0
LILLY ELI & CO COM 532457108 1,721 9,213 SH   DFND 1 9,213 0 0
LYFT INC CL A COM 55087P104 26,174 414,270 SH   DFND 1 414,270 0 0
MASTERCARD INCORPORATED CL A 57636Q104 35,995 101,094 SH   DFND 1 101,094 0 0
MASTERCARD INCORPORATED CL A 57636Q104 39,664 111,400 SH Call DFND 1 111,400 0 0
MCKESSON CORP COM 58155Q103 28,633 146,805 SH   DFND 1 146,805 0 0
MCKESSON CORP COM 58155Q103 39,047 200,200 SH Call DFND 1 200,200 0 0
MERCK & CO. INC COM 58933Y105 17,754 230,300 SH   DFND 1 230,300 0 0
MICRON TECHNOLOGY INC COM 595112103 38,724 439,000 SH   DFND 1 439,000 0 0
MICROSOFT CORP COM 594918104 4,576 19,409 SH   DFND 1 19,409 0 0
MILLER HOWARD HIGH INC EQTY COM SHS BEN IN 600379101 1,917 199,700 SH   DFND 1 199,700 0 0
MIRATI THERAPEUTICS INC COM 60468T105 2,622 15,305 SH   DFND 1 15,305 0 0
MODERNA INC COM 60770K107 4,704 35,922 SH   DFND 1 35,922 0 0
NETEASE INC SPONSORED ADS 64110W102 880 8,525 SH   DFND 1 8,525 0 0
NEXPOINT STRATEGIC OPPORTES COM NEW 65340G205 619 54,358 SH   DFND 1 54,358 0 0
NUVEEN CORE EQUITY ALPHA FD COM 67090X107 2,277 149,700 SH   DFND 1 149,700 0 0
NUVEEN DIVERSIFIED DIVID & I COM 6706EP105 388 40,900 SH   DFND 1 40,900 0 0
NUVEEN FLOATING RATE INCOME COM 67072T108 708 73,244 SH   DFND 1 73,244 0 0
NUVEEN FLTNG RTE INCM OPP FD COM SHS 6706EN100 388 40,700 SH   DFND 1 40,700 0 0
NUVEEN REAL ASSET INCOME & G COM 67074Y105 225 15,293 SH   DFND 1 15,293 0 0
NUVEEN SHT DUR CR OPP FD COM 67074X107 385 27,300 SH   DFND 1 27,300 0 0
NUVEEN TAX-ADVANTAGED DIVID COM 67073G105 695 46,000 SH   DFND 1 46,000 0 0
PENNYMAC FINL SVCS INC NEW COM 70932M107 49,531 740,701 SH   DFND 1 740,701 0 0
PFIZER INC COM 717081103 26,752 738,400 SH   DFND 1 738,400 0 0
PHYSICIANS RLTY TR COM 71943U104 8,519 482,100 SH   DFND 1 482,100 0 0
PINDUODUO INC SPONSORED ADS 722304102 496 3,708 SH   DFND 1 3,708 0 0
REDWOOD TR INC COM 758075402 5,891 565,900 SH   DFND 1 565,900 0 0
REDWOOD TR INC NOTE 4.750% 8/1 758075AC9 1,974 1,978,000 PRN   DFND 1 1,978,000 0 0
REPARE THERAPEUTICS INC COM 760273102 9,946 324,079 SH   DFND 1 324,079 0 0
ROYAL CARIBBEAN GROUP COM V7780T103 39,616 462,747 SH   DFND 1 462,747 0 0
SALIENT MIDSTREAM & MLP FD SH BEN INT 79471V105 953 186,772 SH   DFND 1 186,772 0 0
SIX FLAGS ENTMT CORP NEW COM 83001A102 9,294 200,000 SH Call DFND 1 200,000 0 0
SIX FLAGS ENTMT CORP NEW COM 83001A102 17,245 371,100 SH   DFND 1 371,100 0 0
SIXTH STREET SPECIALTY LENDN COM 83012A109 15,620 742,727 SH   DFND 1 742,727 0 0
SMART GLOBAL HLDGS INC SHS G8232Y101 11,160 242,500 SH   DFND 1 242,500 0 0
SPLUNK INC COM 848637104 3,765 27,790 SH   DFND 1 27,790 0 0
STARWOOD PPTY TR INC NOTE 4.375% 4/0 85571BAH8 11,314 10,815,000 PRN   DFND 1 10,815,000 0 0
TAIWAN SEMICONDUCTOR MFG LTD SPONSORED ADS 874039100 9,202 77,800 SH   DFND 1 77,800 0 0
TELADOC HEALTH INC COM 87918A105 1,562 8,592 SH   DFND 1 8,592 0 0
TEMPLETON GLOBAL INCOME FD COM 880198106 1,199 225,831 SH   DFND 1 225,831 0 0
TESLA INC COM 88160R101 8,924 13,360 SH   DFND 1 13,360 0 0
THERMO FISHER SCIENTIFIC INC COM 883556102 21,697 47,542 SH   DFND 1 47,542 0 0
THERMO FISHER SCIENTIFIC INC COM 883556102 44,634 97,800 SH Call DFND 1 97,800 0 0
TRANSDIGM GROUP INC COM 893641100 26,809 45,600 SH Call DFND 1 45,600 0 0
TRANSDIGM GROUP INC COM 893641100 30,287 51,516 SH   DFND 1 51,516 0 0
TWILIO INC CL A 90138F102 6,444 18,910 SH   DFND 1 18,910 0 0
TWO HBRS INVT CORP NOTE 6.250% 1/1 90187BAA9 2,352 2,299,000 PRN   DFND 1 2,299,000 0 0
UBER TECHNOLOGIES INC COM 90353T100 27,353 501,800 SH   DFND 1 501,800 0 0
UNITEDHEALTH GROUP INC COM 91324P102 24,036 64,600 SH   DFND 1 64,600 0 0
UNIVERSAL HLTH SVCS INC CL B 913903100 22,921 171,835 SH   DFND 1 171,835 0 0
VERACYTE INC COM 92337F107 6,203 115,400 SH Call DFND 1 115,400 0 0
VERACYTE INC COM 92337F107 8,861 164,860 SH   DFND 1 164,860 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100 17,466 81,280 SH   DFND 1 81,280 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100 77,898 362,500 SH Call DFND 1 362,500 0 0
VIRTUS GLOBAL DIVID & INCOME COM 92835W107 1,513 164,476 SH   DFND 1 164,476 0 0
VIRTUS GLOBAL MULTI-SECTOR I COM 92829B101 206 17,332 SH   DFND 1 17,332 0 0
VISA INC COM CL A 92826C839 18,922 89,370 SH   DFND 1 89,370 0 0
VOYA GLBL ADV & PREM OPP FD COM 92912R104 974 101,739 SH   DFND 1 101,739 0 0
VOYA INFRASTRUCTURE INDLS & COM 92912X101 774 62,508 SH   DFND 1 62,508 0 0
VOYA INTL HIGH DIV EQTY INM COM 92912Y109 1,343 240,722 SH   DFND 1 240,722 0 0
VOYA NAT RES EQUITY INCOME F COM 92913C106 3,315 1,001,500 SH   DFND 1 1,001,500 0 0
WELLS FARGO GLOBAL DIVID OPP COM 94987C103 965 183,445 SH   DFND 1 183,445 0 0
ZAI LAB LTD ADR 98887Q104 12,330 92,410 SH   DFND 1 92,410 0 0
ZIMMER BIOMET HOLDINGS INC COM 98956P102 2,364 14,765 SH   DFND 1 14,765 0 0
ZOETIS INC CL A 98978V103 18,741 119,005 SH   DFND 1 119,005 0 0