The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
1LIFE HEALTHCARE INC COM 68269G107 24,492 561,100 SH   DFND 1 561,100 0 0
21VIANET GROUP INC SPONSORED ADS A 90138A103 895 25,800 SH   DFND 1 25,800 0 0
ABBVIE INC COM 00287Y109 8,925 83,290 SH   DFND 1 83,290 0 0
ADVANCED ENERGY INDS COM 007973100 14,914 153,800 SH   DFND 1 153,800 0 0
AGNC INVT CORP COM 00123Q104 30,648 1,964,600 SH   DFND 1 1,964,600 0 0
AIRBNB INC COM CL A 009066101 1,468 10,000 SH   DFND 1 10,000 0 0
ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102 4,572 19,647 SH   DFND 1 19,647 0 0
ALPHABET INC CAP STK CL C 02079K107 25,320 14,453 SH   DFND 1 14,453 0 0
AMAZON COM INC COM 023135106 15,083 4,631 SH   DFND 1 4,631 0 0
AMGEN INC COM 031162100 7,342 31,932 SH   DFND 1 31,932 0 0
ANGEL OAK FINL STRATEGIES IN COM BEN INT 03464A100 342 20,300 SH   DFND 1 20,300 0 0
ANNALY CAPITAL MANAGEMENT IN COM 035710409 36,850 4,360,900 SH   DFND 1 4,360,900 0 0
APELLIS PHARMACEUTICALS INC COM 03753U106 13,296 232,449 SH   DFND 1 232,449 0 0
APOLLO SR FLOATING RATE FD I COM 037636107 198 13,761 SH   DFND 1 13,761 0 0
APPLE INC COM 037833100 48,100 362,500 SH   DFND 1 362,500 0 0
ARES CAPITAL CORP NOTE 3.750% 2/0 04010LAT0 3,077 3,000,000 PRN   DFND 1 3,000,000 0 0
AUTOHOME INC SP ADR RP CL A 05278C107 309 3,100 SH   DFND 1 3,100 0 0
BARINGS BDC INC COM 06759L103 11,829 1,285,726 SH   DFND 1 1,285,726 0 0
BAXTER INTL INC COM 071813109 11,442 142,600 SH   DFND 1 142,600 0 0
BILIBILI INC SPON ADS REP Z 090040106 1,166 13,600 SH   DFND 1 13,600 0 0
BK OF AMERICA CORP COM 060505104 28,767 949,092 SH   DFND 1 949,092 0 0
BROADCOM INC COM 11135F101 10,057 22,970 SH   DFND 1 22,970 0 0
CALAMOS LNG SHR EQT DYNAMIC COM 12812C106 1,400 80,300 SH   DFND 1 80,300 0 0
CARNIVAL CORP UNIT 99/99/9999 143658300 26,701 1,232,740 SH   DFND 1 1,232,740 0 0
CARVANA CO CL A 146869102 28,545 119,164 SH   DFND 1 119,164 0 0
CENTER COAST BRKFLD MLP ENRG SHS BEN INT 151461209 715 75,464 SH   DFND 1 75,464 0 0
CENTRAL SECS CORP COM 155123102 2,247 68,828 SH   DFND 1 68,828 0 0
CHECKMATE PHARMACEUTICALS IN COM 162818108 19,353 1,332,397 SH   DFND 1 1,332,397 0 0
CITIGROUP INC COM NEW 172967424 22,641 367,190 SH   DFND 1 367,190 0 0
COMMUNITY HEALTHCARE TR INC COM 20369C106 22,715 482,159 SH   DFND 1 482,159 0 0
COVETRUS INC COM 22304C100 16,347 568,800 SH   DFND 1 568,800 0 0
CRISPR THERAPEUTICS AG NAMEN AKT H17182108 22,202 145,007 SH   DFND 1 145,007 0 0
CROWDSTRIKE HLDGS INC CL A 22788C105 16,164 76,310 SH   DFND 1 76,310 0 0
D R HORTON INC COM 23331A109 27,072 392,800 SH   DFND 1 392,800 0 0
DBX ETF TR XTRACK HRVST CSI 233051879 5,252 131,100 SH   DFND 1 131,100 0 0
DELAWARE ENHANCED GBL DIV & COM 246060107 1,027 105,426 SH   DFND 1 105,426 0 0
DTF TAX-FREE INCOME INC COM 23334J107 168 11,246 SH   DFND 1 11,246 0 0
DUFF & PHELPS SLT ENGY AND M COM NEW 26433F207 174 35,980 SH   DFND 1 35,980 0 0
DUFF & PHELPS UTIL CORP BD T COM 26432K108 3,258 325,100 SH   DFND 1 325,100 0 0
DYNATRACE INC COM NEW 268150109 4,777 110,400 SH   DFND 1 110,400 0 0
EATON VANCE FLTG RATE INCOM COM SHS BEN INT 278284104 1,597 102,698 SH   DFND 1 102,698 0 0
EATON VANCE FLTING RATE INC COM 278279104 259 19,664 SH   DFND 1 19,664 0 0
EATON VANCE SR INCOME TR SH BEN INT 27826S103 1,126 177,033 SH   DFND 1 177,033 0 0
ETF MANAGERS TR ETFMG ALTR HRVST 26924G508 16,207 1,129,386 SH   DFND 1 1,129,386 0 0
FIRST AMERN FINL CORP COM 31847R102 40,457 783,600 SH   DFND 1 783,600 0 0
FIRST TR SR FLG RTE INCM FD COM 33733U108 950 81,781 SH   DFND 1 81,781 0 0
FIVE9 INC COM 338307101 9,984 57,250 SH   DFND 1 57,250 0 0
FLEXION THERAPEUTICS INC COM 33938J106 14,381 1,246,150 SH   DFND 1 1,246,150 0 0
FUSION PHARMACEUTICALS INC COM 36118A100 4,693 399,399 SH   DFND 1 399,399 0 0
GAMCO GLOBAL GOLD NAT RES & COM SH BEN INT 36465A109 335 95,300 SH   DFND 1 95,300 0 0
GDL FD COM SH BEN IT 361570104 384 44,021 SH   DFND 1 44,021 0 0
GDS HLDGS LTD SPONSORED ADS 36165L108 8,933 95,395 SH   DFND 1 95,395 0 0
GOLUB CAP BDC INC COM 38173M102 11,645 823,525 SH   DFND 1 823,525 0 0
GOSSAMER BIO INC COM 38341P102 4,447 459,834 SH   DFND 1 459,834 0 0
GOSSAMER BIO INC NOTE 5.000% 6/0 38341PAA0 3,170 3,500,000 PRN   DFND 1 3,500,000 0 0
GUGGENHEIM ENHANCED EQUITY I COM 40167B100 312 47,565 SH   DFND 1 47,565 0 0
GW PHARMACEUTICALS PLC ADS 36197T103 10,558 91,486 SH   DFND 1 91,486 0 0
HANCOCK JOHN INVT TR TAX ADV GLB SH 41013P749 956 172,930 SH   DFND 1 172,930 0 0
HERCULES CAPITAL INC DBCV 4.375% 2/0 427096AF9 31 30,000 PRN   DFND 1 30,000 0 0
HERZFELD CARIBBEAN BASIN FD COM 42804T106 344 67,300 SH   DFND 1 67,300 0 0
HIGHLAND GLOBAL ALLOCATION F COM 43010T104 2,891 442,756 SH   DFND 1 442,756 0 0
HIGHLAND INCOME FD HIGHLAND INCOME 43010E404 2,750 267,533 SH   DFND 1 267,533 0 0
HOLOGIC INC COM 436440101 15,830 217,350 SH   DFND 1 217,350 0 0
IDEXX LABS INC COM 45168D104 1,240 2,481 SH   DFND 1 2,481 0 0
INVESCO DYNAMIC CR OPPORTUNI COM 46132R104 1,119 104,200 SH   DFND 1 104,200 0 0
JD.COM INC SPON ADR CL A 47215P106 1,433 16,300 SH   DFND 1 16,300 0 0
JPMORGAN CHASE & CO COM 46625H100 18,991 149,453 SH   DFND 1 149,453 0 0
KURA ONCOLOGY INC COM 50127T109 828 25,361 SH   DFND 1 25,361 0 0
LABORATORY CORP AMER HLDGS COM NEW 50540R409 16,545 81,280 SH   DFND 1 81,280 0 0
LAM RESEARCH CORP COM 512807108 14,050 29,750 SH   DFND 1 29,750 0 0
LAZARD GLOBAL TOTAL RETURN & COM 52106W103 430 24,132 SH   DFND 1 24,132 0 0
LENNAR CORP CL A 526057104 26,871 352,500 SH   DFND 1 352,500 0 0
LILLY ELI & CO COM 532457108 1,556 9,213 SH   DFND 1 9,213 0 0
LUMENTUM HLDGS INC COM 55024U109 11,774 124,200 SH   DFND 1 124,200 0 0
LYFT INC CL A COM 55087P104 10,352 210,700 SH   DFND 1 210,700 0 0
MASIMO CORP COM 574795100 751 2,800 SH   DFND 1 2,800 0 0
MASTERCARD INCORPORATED CL A 57636Q104 17,884 50,104 SH   DFND 1 50,104 0 0
MCKESSON CORP COM 58155Q103 13,405 77,075 SH   DFND 1 77,075 0 0
MICRON TECHNOLOGY INC COM 595112103 36,139 480,700 SH   DFND 1 480,700 0 0
MICROSOFT CORP COM 594918104 23,442 105,394 SH   DFND 1 105,394 0 0
MILLER HOWARD HIGH INC EQTY COM SHS BEN IN 600379101 1,415 182,600 SH   DFND 1 182,600 0 0
MIRATI THERAPEUTICS INC COM 60468T105 3,449 15,705 SH   DFND 1 15,705 0 0
MODERNA INC COM 60770K107 5,752 55,062 SH   DFND 1 55,062 0 0
NETEASE INC SPONSORED ADS 64110W102 1,037 10,825 SH   DFND 1 10,825 0 0
NEW ORIENTAL ED & TECHNOLOGY SPON ADR 647581107 966 5,200 SH   DFND 1 5,200 0 0
NEXPOINT STRATEGIC OPPORTES COM NEW 65340G205 572 54,358 SH   DFND 1 54,358 0 0
NUVEEN CR STRATEGIES INCOME COM SHS 67073D102 1,283 202,717 SH   DFND 1 202,717 0 0
NUVEEN DIVERSIFIED DIVID & I COM 6706EP105 359 40,900 SH   DFND 1 40,900 0 0
NUVEEN FLOATING RATE INCOME COM 67072T108 358 41,000 SH   DFND 1 41,000 0 0
NUVEEN REAL ASSET INCOME & G COM 67074Y105 206 15,293 SH   DFND 1 15,293 0 0
NUVEEN TAX-ADVANTAGED DIVID COM 67073G105 365 25,700 SH   DFND 1 25,700 0 0
NUVEEN TX ADV TOTAL RET STRG COM 67090H102 707 75,000 SH   DFND 1 75,000 0 0
PENNYMAC FINL SVCS INC NEW COM 70932M107 77,295 1,177,918 SH   DFND 1 1,177,918 0 0
PHYSICIANS RLTY TR COM 71943U104 11,104 623,800 SH   DFND 1 623,800 0 0
PINDUODUO INC SPONSORED ADS 722304102 10,554 59,400 SH   DFND 1 59,400 0 0
PIONEER FLOATING RATE TR COM 72369J102 260 25,528 SH   DFND 1 25,528 0 0
QORVO INC COM 74736K101 16,916 101,740 SH   DFND 1 101,740 0 0
QUEST DIAGNOSTICS INC COM 74834L100 28,902 242,525 SH   DFND 1 242,525 0 0
REGENERON PHARMACEUTICALS COM 75886F107 4,050 8,384 SH   DFND 1 8,384 0 0
REPARE THERAPEUTICS INC COM 760273102 9,638 280,979 SH   DFND 1 280,979 0 0
RINGCENTRAL INC CL A 76680R206 9,880 26,070 SH   DFND 1 26,070 0 0
ROYAL CARIBBEAN GROUP COM V7780T103 30,051 402,347 SH   DFND 1 402,347 0 0
ROYCE GLOBAL VALUE TR INC COM 78081T104 733 54,851 SH   DFND 1 54,851 0 0
SALIENT MIDSTREAM & MLP FD SH BEN INT 79471V105 798 186,772 SH   DFND 1 186,772 0 0
SEA LTD SPONSORD ADS 81141R100 9,252 46,480 SH   DFND 1 46,480 0 0
SIXTH STREET SPECIALTY LENDN COM 83012A109 14,279 688,127 SH   DFND 1 688,127 0 0
SMART GLOBAL HLDGS INC SHS G8232Y101 9,133 242,700 SH   DFND 1 242,700 0 0
SMILEDIRECTCLUB INC CL A COM 83192H106 9,051 758,000 SH   DFND 1 758,000 0 0
SPLUNK INC COM 848637104 6,196 36,470 SH   DFND 1 36,470 0 0
SQUARE INC CL A 852234103 13,980 64,235 SH   DFND 1 64,235 0 0
STARWOOD PPTY TR INC NOTE 4.375% 4/0 85571BAH8 2,309 2,315,000 PRN   DFND 1 2,315,000 0 0
STEWART INFORMATION SVCS COR COM 860372101 9,870 204,100 SH   DFND 1 204,100 0 0
TAIWAN SEMICONDUCTOR MFG LTD SPONSORED ADS 874039100 36,910 338,500 SH   DFND 1 338,500 0 0
TAL EDUCATION GROUP SPONSORED ADS 874080104 708 9,900 SH   DFND 1 9,900 0 0
TELADOC HEALTH INC COM 87918A105 4,704 23,525 SH   DFND 1 23,525 0 0
TESLA INC COM 88160R101 18,803 26,645 SH   DFND 1 26,645 0 0
THERMO FISHER SCIENTIFIC INC COM 883556102 26,154 56,152 SH   DFND 1 56,152 0 0
TRANSDIGM GROUP INC COM 893641100 23,337 37,711 SH   DFND 1 37,711 0 0
TWILIO INC CL A 90138F102 9,453 27,925 SH   DFND 1 27,925 0 0
TWO HBRS INVT CORP NOTE 6.250% 1/1 90187BAA9 2,330 2,299,000 PRN   DFND 1 2,299,000 0 0
VANECK VECTORS ETF TR PHARMACEUTICAL 92189F692 21,962 330,400 SH   DFND 1 330,400 0 0
VERACYTE INC COM 92337F107 9,453 193,160 SH   DFND 1 193,160 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100 20,467 86,600 SH   DFND 1 86,600 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100 35,451 150,000 SH Call DFND 1 150,000 0 0
VIRTUS GLOBAL DIVID & INCOME COM 92835W107 2,129 242,479 SH   DFND 1 242,479 0 0
VIRTUS GLOBAL MULTI-SECTOR I COM 92829B101 210 17,332 SH   DFND 1 17,332 0 0
VOYA GLBL ADV & PREM OPP FD COM 92912R104 528 60,339 SH   DFND 1 60,339 0 0
VOYA INFRASTRUCTURE INDLS & COM 92912X101 502 48,711 SH   DFND 1 48,711 0 0
VOYA PRIME RATE TR SH BEN INT 92913A100 4,093 915,600 SH   DFND 1 915,600 0 0
WELLS FARGO GLOBAL DIVIDEND COM 94987C103 890 183,445 SH   DFND 1 183,445 0 0
WORKDAY INC CL A 98138H101 4,133 17,250 SH   DFND 1 17,250 0 0
ZAI LAB LTD ADR 98887Q104 15,637 115,540 SH   DFND 1 115,540 0 0
ZIMMER BIOMET HOLDINGS INC COM 98956P102 2,365 15,345 SH   DFND 1 15,345 0 0
ZOETIS INC CL A 98978V103 6,980 42,175 SH   DFND 1 42,175 0 0