The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ADVENT CLAY CONV SEC INC FD COM 007639107 87 14,561 SH   DFND 1 14,561 0 0
ADVENT CLAYMORE ENH GRW & IN COM 00765E104 282 33,866 SH   DFND 1 33,866 0 0
ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102 37,193 215,700 SH   DFND 1 215,700 0 0
ALIGN TECHNOLOGY INC COM 016255101 9,053 40,745 SH   DFND 1 40,745 0 0
ALPINE TOTAL DYNAMIC DIVID F COM SH BEN INT N 021060207 192 20,300 SH   DFND 1 20,300 0 0
ALTABA INC COM 021346101 30,008 429,600 SH   DFND 1 429,600 0 0
ALTICE USA INC COM 02156K103 6,099 287,300 SH   DFND 1 287,300 0 0
AMAZON COM INC COM 023135106 24,928 21,316 SH   DFND 1 21,316 0 0
AMC ENTMT HLDGS INC CL A COM 00165C104 180 11,900 SH   DFND 1 11,900 0 0
AMERICAN TOWER CORP NEW COM 03027X100 10,486 73,500 SH   DFND 1 73,500 0 0
APELLIS PHARMACEUTICALS INC COM 03753U106 19,667 917,116 SH   DFND 1 917,116 0 0
APPLE INC COM 037833100 27,738 163,910 SH   DFND 1 163,910 0 0
ARBOR RLTY TR INC COM 038923108 1,489 172,300 SH   DFND 1 172,300 0 0
ARES CAP CORP COM 04010L103 39,407 2,506,800 SH   DFND 1 2,506,800 0 0
BAIDU INC SPON ADR REP A 056752108 9,573 40,872 SH   DFND 1 40,872 0 0
BANK AMER CORP COM 060505104 59,972 2,031,558 SH   DFND 1 2,031,558 0 0
BAOZUN INC SPONSORED ADR 06684L103 5,390 170,800 SH   DFND 1 170,800 0 0
BIOGEN INC COM 09062X103 8,830 27,717 SH   DFND 1 27,717 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 3,517 39,445 SH   DFND 1 39,445 0 0
BIOVERATIV INC COM 09075E100 5,856 108,600 SH   DFND 1 108,600 0 0
BLACKROCK MUNI INTER DR FD I COM 09253X102 174 12,500 SH   DFND 1 12,500 0 0
BLACKSTONE MTG TR INC COM CL A 09257W100 38,429 1,194,200 SH   DFND 1 1,194,200 0 0
BLUEBIRD BIO INC COM 09609G100 734 4,120 SH   DFND 1 4,120 0 0
BOSTON SCIENTIFIC CORP COM 101137107 2,362 95,300 SH   DFND 1 95,300 0 0
BRISTOL MYERS SQUIBB CO COM 110122108 7,866 128,360 SH   DFND 1 128,360 0 0
BROADCOM LTD SHS Y09827109 22,806 88,775 SH   DFND 1 88,775 0 0
BROOKFIELD GLOBL LISTED INFR COM SHS 11273Q109 475 36,700 SH   DFND 1 36,700 0 0
CARDIOME PHARMA CORP COM NO PAR 14159U301 4,135 2,667,585 SH   DFND 1 2,667,585 0 0
CARTER INC COM 146229109 276 2,350 SH   DFND 1 2,350 0 0
CARVANA CO CL A 146869102 15,662 819,150 SH   DFND 1 819,150 0 0
CELGENE CORP COM 151020104 10,754 103,047 SH   DFND 1 103,047 0 0
CHILDRENS PL INC COM 168905107 291 2,000 SH   DFND 1 2,000 0 0
CINEMARK HOLDINGS INC COM 17243V102 212 6,100 SH   DFND 1 6,100 0 0
CITIGROUP INC W EXP 01/04/201 172967226 27 271,800 SH   DFND 1 271,800 0 0
CITIGROUP INC COM NEW 172967424 51,547 692,743 SH   DFND 1 692,743 0 0
CLOVIS ONCOLOGY INC COM 189464100 10,454 153,735 SH   DFND 1 153,735 0 0
COGNIZANT TECHNOLOGY SOLUTIO CL A 192446102 16,320 229,800 SH   DFND 1 229,800 0 0
COHEN & STEERS GLOBAL INC BL COM 19248M103 156 15,802 SH   DFND 1 15,802 0 0
COHEN & STEERS INFRASTRUCTUR COM 19248A109 989 41,200 SH   DFND 1 41,200 0 0
COMMUNITY HEALTHCARE TR INC COM 20369C106 6,477 230,500 SH   DFND 1 230,500 0 0
CORNERSTONE STRATEGIC VALUE COM 21924B302 667 43,119 SH   DFND 1 43,119 0 0
CORNERSTONE TOTAL RTRN FD IN COM 21924U300 772 50,480 SH   DFND 1 50,480 0 0
CREDIT ACCEP CORP MICH COM 225310101 21,856 67,565 SH   DFND 1 67,565 0 0
CREDIT SUISSE NASSAU BRH VELOCITY SHS SHR 22542D357 222 40,100 SH   DFND 1 40,100 0 0
CRISPR THERAPEUTICS AG NAMEN AKT H17182108 20,912 890,631 SH   DFND 1 890,631 0 0
CTRIP COM INTL LTD AMERICAN DEP SHS 22943F100 9,127 206,970 SH   DFND 1 206,970 0 0
CYPRESS SEMICONDUCTOR CORP COM 232806109 10,228 671,100 SH   DFND 1 671,100 0 0
D R HORTON INC COM 23331A109 14,596 285,795 SH   DFND 1 285,795 0 0
DERMIRA INC COM 24983L104 4,925 177,085 SH   DFND 1 177,085 0 0
DOUBLELINE OPPORTUNISTIC CR COM 258623107 377 17,000 SH   DFND 1 17,000 0 0
DUFF & PHELPS SLCT ENGY MLP COM 26433F108 952 162,731 SH   DFND 1 162,731 0 0
EATON VANCE RISK MNGD DIV EQ COM 27829G106 113 11,700 SH   DFND 1 11,700 0 0
EATON VANCE TAX-ADV BD & OPT COM SH BEN INT 27829M103 211 20,618 SH   DFND 1 20,618 0 0
EQUINIX INC COM PAR $0.001 29444U700 10,474 23,110 SH   DFND 1 23,110 0 0
EXPRESS SCRIPTS HLDG CO COM 30219G108 15,846 212,300 SH   DFND 1 212,300 0 0
FACEBOOK INC CL A 30303M102 25,618 145,180 SH   DFND 1 145,180 0 0
FIDUCIARY CLAYMORE MLP OPP F COM 31647Q106 483 36,700 SH   DFND 1 36,700 0 0
FIRST TR HIGH INCOME L/S FD COM 33738E109 487 29,400 SH   DFND 1 29,400 0 0
FLOOR & DECOR HLDGS INC CL A 339750101 321 6,600 SH   DFND 1 6,600 0 0
FRANKLIN LTD DURATION INC TR COM 35472T101 158 13,388 SH   DFND 1 13,388 0 0
FRANKLIN RES INC COM 354613101 4,836 111,600 SH   DFND 1 111,600 0 0
GABELLI EQUITY TR INC COM 362397101 1,873 302,543 SH   DFND 1 302,543 0 0
GALAPAGOS NV SPON ADR 36315X101 6,231 66,453 SH   DFND 1 66,453 0 0
GLOBAL MED REIT INC COM NEW 37954A204 5,125 625,000 SH   DFND 1 625,000 0 0
GODADDY INC CL A 380237107 9,945 197,800 SH   DFND 1 197,800 0 0
GOLUB CAP BDC INC COM 38173M102 12,370 679,666 SH   DFND 1 679,666 0 0
GUGGENHEIM CR ALLOCATION FD COM 40168G108 474 21,600 SH   DFND 1 21,600 0 0
GW PHARMACEUTICALS PLC ADS 36197T103 9,620 72,871 SH   DFND 1 72,871 0 0
HANCOCK JOHN INV TRUST TAX ADV GLB SH 41013P749 938 106,400 SH   DFND 1 106,400 0 0
HIGHLAND FLOATNG RATE OPPRT SHS BEN INT 43010E404 947 61,127 SH   DFND 1 61,127 0 0
HOLOGIC INC COM 436440101 1,233 28,848 SH   DFND 1 28,848 0 0
HOME DEPOT INC COM 437076102 455 2,400 SH   DFND 1 2,400 0 0
IMAX CORP COM 45245E109 416 17,960 SH   DFND 1 17,960 0 0
INCYTE CORP COM 45337C102 350 3,700 SH   DFND 1 3,700 0 0
INTRA CELLULAR THERAPIES INC COM 46116X101 10,135 699,950 SH   DFND 1 699,950 0 0
IRHYTHM TECHNOLOGIES INC COM 450056106 1,508 26,900 SH   DFND 1 26,900 0 0
ISHARES TR MSCI INDIA ETF 46429B598 2,521 69,900 SH   DFND 1 69,900 0 0
IVY HIGH INC OPPORTUNITIES F COM 465893105 576 38,100 SH   DFND 1 38,100 0 0
JAZZ PHARMACEUTICALS PLC SHS USD G50871105 431 3,200 SH   DFND 1 3,200 0 0
JD COM INC SPON ADR CL A 47215P106 17,728 428,000 SH   DFND 1 428,000 0 0
JPMORGAN CHASE & CO COM 46625H100 38,188 357,100 SH   DFND 1 357,100 0 0
KKR INCOME OPPORTUNITIES FD COM 48249T106 961 59,901 SH   DFND 1 59,901 0 0
KURA ONCOLOGY INC COM 50127T109 3,255 212,761 SH   DFND 1 212,761 0 0
LADDER CAP CORP CL A 505743104 10,115 742,078 SH   DFND 1 742,078 0 0
LAM RESEARCH CORP COM 512807108 21,947 119,230 SH   DFND 1 119,230 0 0
LENNAR CORP CL B 526057302 325 6,291 SH   DFND 1 6,291 0 0
LENNAR CORP CL A 526057104 12,857 203,297 SH   DFND 1 203,297 0 0
LIBERTY ALL STAR EQUITY FD SH BEN INT 530158104 377 59,900 SH   DFND 1 59,900 0 0
LIBERTY BROADBAND CORP COM SER C 530307305 48,920 574,445 SH   DFND 1 574,445 0 0
LIBERTY INTERACTIVE CORP LBT VEN COM A NE 53071M856 42,263 779,192 SH   DFND 1 779,192 0 0
LOGMEIN INC COM 54142L109 11,819 103,224 SH   DFND 1 103,224 0 0
MADISON CVRED CALL & EQ STR COM 557437100 285 36,965 SH   DFND 1 36,965 0 0
MFS HIGH YIELD MUN TR SH BEN INT 59318E102 54 11,695 SH   DFND 1 11,695 0 0
MICROCHIP TECHNOLOGY INC COM 595017104 10,537 119,900 SH   DFND 1 119,900 0 0
MICRON TECHNOLOGY INC COM 595112103 13,183 320,600 SH   DFND 1 320,600 0 0
MICROSOFT CORP COM 594918104 31,102 363,600 SH   DFND 1 363,600 0 0
MILLER HOWARD HIGH INC EQTY COM SHS BEN IN 600379101 538 43,161 SH   DFND 1 43,161 0 0
MORGAN STANLEY CHINA A SH FD COM 617468103 821 35,100 SH   DFND 1 35,100 0 0
NETEASE INC SPONSORED ADR 64110W102 552 1,600 SH   DFND 1 1,600 0 0
NUVEEN FLTNG RTE INCM OPP FD COM SHS 6706EN100 381 33,400 SH   DFND 1 33,400 0 0
NUVEEN REAL ESTATE INCOME FD COM 67071B108 782 69,457 SH   DFND 1 69,457 0 0
NXSTAGE MEDICAL INC COM 67072V103 4,989 205,900 SH   DFND 1 205,900 0 0
ORBOTECH LTD ORD M75253100 5,145 102,400 SH   DFND 1 102,400 0 0
PFIZER INC COM 717081103 7,632 210,700 SH   DFND 1 210,700 0 0
PHYSICIANS RLTY TR COM 71943U104 2,447 136,000 SH   DFND 1 136,000 0 0
PIMCO STRATEGIC INCOME FD IN COM 72200X104 352 38,300 SH   DFND 1 38,300 0 0
POOL CORPORATION COM 73278L105 311 2,400 SH   DFND 1 2,400 0 0
PULTE GROUP INC COM 745867101 11,481 345,294 SH   DFND 1 345,294 0 0
REAVES UTIL INCOME FD COM SH BEN INT 756158101 1,423 45,977 SH   DFND 1 45,977 0 0
SALESFORCE COM INC COM 79466L302 15,447 151,100 SH   DFND 1 151,100 0 0
SERVICE CORP INTL COM 817565104 6,116 163,868 SH   DFND 1 163,868 0 0
SERVICENOW INC COM 81762P102 6,376 48,900 SH   DFND 1 48,900 0 0
SIENNA BIOPHARMACEUTICALS IN COM 82622H108 14,206 785,309 SH   DFND 1 785,309 0 0
SOLAR CAP LTD COM 83413U100 16,152 799,231 SH   DFND 1 799,231 0 0
STARWOOD PPTY TR INC COM 85571B105 49,423 2,314,882 SH   DFND 1 2,314,882 0 0
STONE HBR EMERG MRKTS INC FD COM 86164T107 251 15,749 SH   DFND 1 15,749 0 0
TAIWAN SEMICONDUCTOR MFG LTD SPONSORED ADR 874039100 1,538 38,800 SH   DFND 1 38,800 0 0
TAL ED GROUP ADS REPSTG COM 874080104 3,007 101,200 SH   DFND 1 101,200 0 0
TCG BDC INC COM 872280102 5,024 250,700 SH   DFND 1 250,700 0 0
TEKLA HEALTHCARE INVS SH BEN INT 87911J103 760 33,700 SH   DFND 1 33,700 0 0
TEKLA WORLD HEALTHCARE FD BEN INT SHS 87911L108 814 59,837 SH   DFND 1 59,837 0 0
TOLL BROTHERS INC COM 889478103 389 8,100 SH   DFND 1 8,100 0 0
TORTOISE ENERGY INDEPENDENC COM 89148K101 416 31,297 SH   DFND 1 31,297 0 0
TPG SPECIALTY LENDING INC COM 87265K102 11,138 562,511 SH   DFND 1 562,511 0 0
TRI POINTE HOMES INC COM 87265H109 6,107 340,771 SH   DFND 1 340,771 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100 9,843 65,682 SH   DFND 1 65,682 0 0
VIASAT INC COM 92552V100 29,461 393,601 SH   DFND 1 393,601 0 0
VIRTUS TOTAL RETURN FUND INC COM 92837G100 679 52,641 SH   DFND 1 52,641 0 0
WAVE LIFE SCIENCES LTD SHS Y95308105 5,595 159,403 SH   DFND 1 159,403 0 0
WAYFAIR INC CL A 94419L101 9,424 117,400 SH   DFND 1 117,400 0 0
WELLS FARGO ADV GLB DIV OPP COM 94987C103 957 161,425 SH   DFND 1 161,425 0 0
WELLS FARGO ADVANTAGE MULTI COM SHS 94987D101 946 72,445 SH   DFND 1 72,445 0 0
WISDOMTREE TR INDIA ERNGS FD 97717W422 6,826 245,200 SH   DFND 1 245,200 0 0