AngioDynamics Third Quarter Fiscal Year 2025 Earnings Presentation April 2, 2025

Forward-Looking Statements 2 Notice Regarding Forward-Looking Statements This presentation contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. All statements regarding AngioDynamics’ expected future financial position, results of operations, cash flows, business strategy, budgets, projected costs, capital expenditures, products, competitive positions, growth opportunities, plans and objectives of management for future operations, as well as statements that include the words such as “expects,” “reaffirms,” “intends,” “anticipates,” “plans,” “projects,” “believes,” “seeks,” “estimates,” “optimistic,” or variations of such words and similar expressions, are forward-looking statements. These forward-looking statements are not guarantees of future performance and are subject to risks and uncertainties. Investors are cautioned that actual events or results may differ materially from AngioDynamics’ expectations, expressed or implied. Factors that may affect the actual results achieved by AngioDynamics include, without limitation, the scale and scope of the COVID-19 global pandemic, the ability of AngioDynamics to develop its existing and new products, technological advances and patents attained by competitors, infringement of AngioDynamics’ technology or assertions that AngioDynamics’ technology infringes the technology of third parties, the ability of AngioDynamics to effectively compete against competitors that have substantially greater resources, future actions by the FDA or other regulatory agencies, domestic and foreign health care reforms and government regulations, results of pending or future clinical trials, overall economic conditions (including inflation, labor shortages and supply chain challenges including the cost and availability of raw materials), the results of on-going litigation, challenges with respect to third-party distributors or joint venture partners or collaborators, the results of sales efforts, the effects of product recalls and product liability claims, changes in key personnel, the ability of AngioDynamics to execute on strategic initiatives, the effects of economic, credit and capital market conditions, general market conditions, market acceptance, foreign currency exchange rate fluctuations, the effects on pricing from group purchasing organizations and competition, the ability of AngioDynamics to obtain regulatory clearances or approval of its products, or to integrate acquired businesses, as well as the risk factors listed from time to time in AngioDynamics’ SEC filings, including but not limited to its Annual Report on Form 10-K for the year ended May 31, 2024. AngioDynamics does not assume any obligation to publicly update or revise any forward-looking statements for any reason. Notice Regarding Non-GAAP Financial Measures Management uses non-GAAP measures to establish operational goals and believes that non-GAAP measures may assist investors in analyzing the underlying trends in AngioDynamics’ business over time. Investors should consider these non-GAAP measures in addition to, not as a substitute for or as superior to, financial reporting measures prepared in accordance with GAAP. In this presentation, AngioDynamics has reported pro forma results, adjusted EBITDA (income before interest, taxes, depreciation and amortization and stock-based compensation); adjusted net income and adjusted earnings per share. Management uses these measures in its internal analysis and review of operational performance. Management believes that these measures provide investors with useful information in comparing AngioDynamics’ performance over different periods. By using these non-GAAP measures, management believes that investors get a better picture of the performance of AngioDynamics’ underlying business. Management encourages investors to review AngioDynamics’ financial results prepared in accordance with GAAP to understand AngioDynamics’ performance taking into account all relevant factors, including those that may only occur from time to time but have a material impact on AngioDynamics’ financial results. Please see the tables that follow for a reconciliation of non-GAAP measures to measures prepared in accordance with GAAP.

FY Q3 2025 Key Takeaways 3 CONTINUED COMMERCIAL EXECUTION 9% YoY pro forma total revenue growth MedTech segment pro forma revenue growth of 22% YoY Auryon sales of $13.9 million, growth of 17% YoY AngioVac sales of $6.8 million, growth of 23% YoY AlphaVac sales of $3.0 million, growth of 161% YoY NanoKnife probe sales of $4.9 million, growth of 16% YoY ACHIEVED KEY CLINICAL, REGULATORY & MARKET ACCESS MILESTONES Received FDA clearance for NanoKnife for prostate tissue ablation INCREASED FULL YEAR 2025 GUIDANCE Increased revenue, Med Tech growth, gross margin, adjusted EBITDA, and adjusted EPS guidance Continued commercial and operational execution positions AngioDynamics to drive accelerated, profitable growth moving forward SUSTAINED PROFITABILITY Reported pro forma Adj. EBITDA of $1.3M, improving from ($3.6)M in Q3 FY24

4 0.9% Pro Forma Growth 22.2% Pro Forma Growth Segment Revenue Contribution Segment Gross Margin 47.4% 62.5% Med Device Med Tech Q3 FY 2025 Pro Forma Financial Snapshot

5 (1.1)% Pro Forma Growth 18.6% Pro Forma Growth Segment Revenue Contribution Segment Gross Margin 47.8% 63.2% Med Device Med Tech YTD FY 2025 Pro Forma Financial Snapshot

Med Tech - Auryon 6 Cumulative sales of ~$170M since launch in Sept 2020 Continued penetration into hospital setting Launched 1.7mm Catheter in Q1 FY25 European CE Mark approval in Q1 FY25 Initiated the AMBITION BTK RCT and Registry to generate definitive clinical evidence supporting the use of the Auryon Atherectomy System in treating below the knee lesions in patients with critical limb ischemia. Period Sales YoY Growth Q3 2025 $13.9M 17.3% YTD 2025 $41.3M 21.2%

Med Tech - Thrombus Management 7 AngioVac and AlphaVac combined represent a strong, comprehensive mechanical thrombectomy portfolio AngioVac 23.1% YoY growth in Q3 and 20.2% YoY growth YTD AlphaVac Published APEX-AV trial results in JSCAI showing AlphaVac System achieved 35.5% clot reduction, comparing favorably to other aspiration devices, with improved RV/LV ratio and pulmonary artery pressures. 3Q 2025 Sales YoY Growth AngioVac $6.8M 23.1% AlphaVac $3.0M 161.4% Total Mech Thromb. $9.8M 46.7% Unifuse $1.4M 17.3% Total Thrombus Mgmt. $11.2M 42.2% YTD 2025 Sales YoY Growth AngioVac $20.7M 20.2% AlphaVac $7.7M 59.0% Total Mech Thromb. $28.4M 28.7% Unifuse $3.8M 13.4% Total Thrombus Mgmt. $32.2M 26.7%

Med Tech - NanoKnife 8 Received CPT Category 1 Code (effective Jan. 1, 2026), which is expected to streamline reimbursement for healthcare providers conducting irreversible electroporation (IRE) ablation procedures. Announced PRESERVE clinical study met primary endpoints: At 12-months post-procedure: 84.0% of patients were free from in-field, clinically significant disease Demonstrated strong quality of life outcomes Received FDA clearance for prostate tissue ablation (Dec. 2024) 3Q 2025 Sales YoY Growth Disposables $4.9M 16.2% Capital $1.3M (21.6)% Total $6.3M 5.3% YTD 2025 Sales YoY Growth Disposables $14.0M 11.3% Capital $3.3M (26.5)% Total $17.3M 1.3%

Med Device 9 3Q 2025 Sales YoY Growth Core Peripheral $19.4M 3.5% Venous / EVLT $6.6M (2.8)% Ports $8.7M (2.1)% Solero Microwave $4.6 8.6% Alatus and Isoloc Balloons $0.9M (9.8)% Other Med Device $0.5M (32.1)% Total $40.7M 0.9% YTD 2025 Sales YoY Growth Core Peripheral $56.8M 0.5% Venous / EVLT $20.1M (0.2)% Ports $26.9M 0.3% Solero Microwave $13.5M (7.2)% Alatus and Isoloc Balloons $3.0M (8.7)% Other Med Device $1.4M (16.4)% Total $121.7M (1.1)%

Fiscal Year 2025 Guidance 10 Metric Updated Guidance (Issued Apr. 2, 2025) Previous Guidance (Issued Jan. 8, 2025) Full Year Net Sales $285 - $288 million $282 - $288 million Med Tech Net Sales 14 – 16% YoY growth 12 – 15% YoY growth Med Device Net Sales Flat (unchanged) Flat Gross Margin 53 - 54% 52 - 53% Adjusted EBITDA $4.0 - $5.0 million $1.0 - $3.0 million Adjusted EPS ($0.31) – ($0.34) ($0.34) – ($0.38)

11 Auryon Received CE Mark in Q1 FY2025 Moved to full market release in EU during first quarter of calendar 2025 Continuing to increase penetration in the hospital setting in the U.S. AlphaVac Executing full commercial launch of PE indication in U.S. and CE Marked countries Launching new products to refine and enhance usability NanoKnife Received CPT1 Code for IRE for the treatment of prostate tissue Received FDA clearance for prostate tissue in December Expanded commercial launch in-process for prostate following clearance Fiscal Year 2025 Catalysts

Appendix 12

Reconciliation of GAAP to Non-GAAP Pro Forma Results for the Consolidated Income Statements 13

Reconciliation of GAAP Net Loss to Non-GAAP Adjusted Net Income (Loss) and EPS 14 Reconciliation of Net Loss to Adjusted EBITDA

Reconciliation of Non-GAAP Pro Forma Net Loss to Adjusted Pro Forma Net Loss and EPS 15 Reconciliation of Non-GAAP Pro Forma Net Loss to Adjusted Pro Forma EBITDA

16 Detail of “Acquisition, Restructuring and Other Items, net”

17 Reconciliation of GAAP to Non-GAAP Pro Forma Results for Sales and Gross Margin by Product Category