Property and Equipment, Net

12 Months Ended

Dec. 31, 2018

Property Plant And Equipment [Abstract]

Property and Equipment, Net

8. Property and Equipment, Net

Property and equipment, net as of December 31, 2018 and 2017 consisted of the following:

	December 31,
(in thousands)	2018			2017
Lab equipment	$	13,304		$	13,486
IT equipment		3,781			3,853
Leasehold improvements		19,392			20,790
Furniture and fixtures		306			335
Construction in process		—			30
Total property and equipment, gross		36,783			38,494
Less: Accumulated depreciation		(34,514	)		(32,027	)
Total property and equipment, net	$	2,269		$	6,467

Depreciation expense was $4.1 million and $5.1 million for the years ended December 31, 2018 and 2017, respectively.

During the year ended December 31, 2018, the Company recognized a $0.2 million loss related to the disposal of property and equipment. There were no significant losses recognized related to the disposal of property and equipment during the year ended December 31, 2017. During the year ended December 31, 2017, the Company recognized a $0.4 million gain on the sale of equipment. There were no significant gains recognized related to the sale of property and equipment during the year ended December 31, 2018.