Sale of Commercial Business - Schedule of Discontinued Operations and Assets Held for Sale (Detail) - USD ($) $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2017	Sep. 30, 2016	Sep. 30, 2017	Sep. 30, 2016
Other income and expenses:
Income tax benefit (expense)	$ 5,000	$ (9,800)	$ (47,000)	$ (9,800)
Total income (loss) from discontinued operations	8,456	(3,430)	547,994	(3,698)
Commercial Business [Member]
Revenues:
Product revenues, net		14,493	16,135	37,312
License and collaboration revenues		12,417	7,797	43,062
Other revenues		1,161	1,973	2,659
Total revenues		28,071	25,905	83,033
Costs and expenses:
Cost of revenues		1,010	3,890	3,593
Research and development expenses		3,830	3,730	22,012
Selling, general and administrative expenses		11,600	8,732	35,485
Restructuring expenses			9,535
Total costs and expenses		16,440	25,887	61,090
Other income and expenses:
Interest expense		(5,291)	(6,743)	(15,871)
Gain on sale of commercial business	3,497		601,670
Income from discontinued operations	3,497	6,340	594,945	6,072
Income tax benefit (expense)	4,959	(9,770)	(46,951)	(9,770)
Total income (loss) from discontinued operations	$ 8,456	$ (3,430)	$ 547,994	$ (3,698)