Sale of Commercial Business - Schedule of Discontinued Operations and Assets Held for Sale (Detail) - Commercial Business [Member] - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2017	Mar. 31, 2016
Revenues:
Product revenues, net	$ 16,135	$ 9,968
License and collaboration revenues	7,797	11,313
Other revenues	1,973
Total revenues	25,905	21,281
Costs and expenses:
Cost of revenues	3,890	711
Research and development expenses	3,730	4,880
Selling, general and administrative expenses	8,733	11,343
Restructuring expenses	5,265
Total costs and expenses	21,618	16,934
Other income and expenses:
Interest expense	(5,234)	(5,290)
Loss from discontinued operations	$ (947)	$ (943)