Accounts Payable, Accrued Expenses and Other - Schedule of Accounts Payable, Accrued Expenses and Other (Detail) - USD ($) $ in Thousands	Dec. 31, 2016	Dec. 31, 2015
Accounts Payable And Accrued Liabilities [Line Items]
Accounts payable	$ 3,384	$ 5,049
Accrued goods and services	15,760	14,295
Accrued clinical trial costs	11,260	12,764
Accrued drug purchase costs	910	7,460
Accrued payroll and related benefits	9,150	9,009
Accrued restructuring expenses	774
Accrued asset sale transaction costs	3,724
Accrued interest	2,100	3,041
Accrued dividends payable	19	19
Deferred tax incentives	1,402	445
Total accounts payable, accrued expenses and other	49,982	$ 52,082
Silver Creek [Member]
Accounts Payable And Accrued Liabilities [Line Items]
Warrant liability	$ 1,499