Property and Equipment, Net - Schedule of Property and Equipment, Net (Detail) - USD ($) $ in Thousands	Dec. 31, 2016	Dec. 31, 2015
Property, Plant and Equipment [Line Items]
Total property and equipment, gross	$ 51,980	$ 51,226
Less: Accumulated depreciation	(36,215)	(29,311)
Total property and equipment, net	15,765	21,915
Lab Equipment [Member]
Property, Plant and Equipment [Line Items]
Total property and equipment, gross	20,752	19,305
IT Equipment [Member]
Property, Plant and Equipment [Line Items]
Total property and equipment, gross	8,601	7,742
Leasehold Improvements [Member]
Property, Plant and Equipment [Line Items]
Total property and equipment, gross	21,153	21,026
Furniture and Fixtures [Member]
Property, Plant and Equipment [Line Items]
Total property and equipment, gross	959	910
Construction in Process [Member]
Property, Plant and Equipment [Line Items]
Total property and equipment, gross	$ 515	$ 2,243