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License and Collaboration Agreements - Schedule of Revenue Recognized and Assets and Liabilities under Collaborative Arrangements (Detail) - USD ($)
3 Months Ended 12 Months Ended
Dec. 31, 2016
Sep. 30, 2016
Jun. 30, 2016
Mar. 31, 2016
Dec. 31, 2015
Sep. 30, 2015
Jun. 30, 2015
Mar. 31, 2015
Dec. 31, 2016
Dec. 31, 2015
Dec. 31, 2014
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                      
Total $ 44,057,000 $ 12,417,000 $ 19,332,000 $ 11,313,000 $ 17,090,000 $ 16,440,000 $ 36,558,000 $ 14,842,000 $ 87,119,000 $ 84,930,000 $ 102,756,000
Sanofi [Member]                      
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                      
Total                 0 0  
License and Collaboration Agreements [Member] | Baxalta [Member]                      
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                      
Proportional performance revenue recognition model                 47,119,000 64,930,000 10,460,000
Substantive milestones                 40,000,000 20,000,000  
Total                 87,119,000 84,930,000 10,460,000
Accounts receivable, billed 860,000       1,336,000       860,000 1,336,000  
Accounts receivable, unbilled 581,000       626,000       581,000 626,000  
Deferred revenues $ 56,779,000       $ 97,365,000       $ 56,779,000 $ 97,365,000  
License and Collaboration Agreements [Member] | Sanofi [Member]                      
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                      
Total                     92,296,000
Upfront payment                     39,306,000
Milestone payment                     16,377,000
Development services                     18,904,000
Manufacturing services and other                     $ 17,709,000