Accounts Payable, Accrued Expenses and Other - Schedule of Accounts Payable, Accrued Expenses and Other (Detail) - USD ($) $ in Thousands	Sep. 30, 2016	Dec. 31, 2015
Payables And Accruals [Abstract]
Accounts payable	$ 8,114	$ 5,049
Accrued goods and services	13,602	14,295
Accrued clinical trial costs	11,495	12,764
Accrued drug purchase costs	35	7,460
Accrued payroll and related benefits	8,186	9,009
Accrued restructuring expenses	809
Accrued interest	6,447	3,041
Accrued dividends payable	19	19
Deferred tax incentives	992	445
Total accounts payable, accrued expenses and other	$ 49,699	$ 52,082