Accounts Payable, Accrued Expenses and Other - Schedule of Accounts Payable, Accrued Expenses and Other (Detail) - USD ($) $ in Thousands	Jun. 30, 2016	Dec. 31, 2015
Payables And Accruals [Abstract]
Accounts payable	$ 12,046	$ 5,049
Accrued goods and services	13,954	14,295
Accrued clinical trial costs	9,696	12,764
Accrued drug purchase costs	155	7,460
Accrued payroll and related benefits	6,381	9,009
Accrued interest	2,100	3,041
Accrued dividends payable	19	19
Deferred tax incentives	445	445
Total accounts payable, accrued expenses and other	$ 44,796	$ 52,082