Condensed Consolidated Statements of Cash Flows - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2016	Mar. 31, 2015
Cash flows from operating activities
Net loss	$ (38,658)	$ (34,432)
Adjustments to reconcile net loss to net cash used in operating activities
Non-cash interest expense	2,190	1,937
Depreciation and amortization	1,537	1,054
Stock-based compensation	3,533	3,370
Changes in operating assets and liabilities:
Accounts receivable	(9,154)	(935)
Inventory	(4,366)
Accounts payable, accrued expenses and other	(1,205)	4,649
Deferred revenues	(9,134)	(12,222)
Other assets and liabilities, net	1,734	1,500
Net cash used in operating activities	(53,523)	(35,079)
Cash flows from investing activities
Purchases of marketable securities	(84,262)
Proceeds from sales and maturities of marketable securities		25,163
Purchases of property and equipment	(1,229)	(1,204)
Net cash (used in) provided by investing activities	(85,491)	23,959
Cash flows from financing activities
Proceeds from exercise of options and warrants to purchase common stock	1,645	3,136
Proceeds from issuance of preferred stock by Silver Creek Pharmaceuticals, Inc.		1,129
Net cash provided by financing activities	1,645	4,265
Net decrease in cash and cash equivalents	(137,369)	(6,855)
Cash and cash equivalents, beginning of period	185,606	35,688
Cash and cash equivalents, end of period	48,237	28,833
Non-cash investing and financing activities
Property and equipment in accounts payable and accrued expenses	388	1,177
Receivables related to stock option exercises in prepaid expenses and other current assets	53	200
Supplemental disclosure of cash flows
Cash paid for interest	$ 2,813	$ 3,868