Accounts Payable, Accrued Expenses and Other - Schedule of Accounts Payable, Accrued Expenses and Other (Detail) - USD ($) $ in Thousands	Mar. 31, 2016	Dec. 31, 2015
Payables and Accruals [Abstract]
Accounts payable	$ 10,784	$ 5,049
Accrued goods and services	12,574	14,295
Accrued clinical trial costs	12,433	12,764
Accrued drug purchase costs	1,662	7,460
Accrued payroll and related benefits	5,866	9,009
Accrued interest	6,666	3,041
Accrued dividends payable	19	19
Deferred tax incentives	445	445
Total accounts payable, accrued expenses and other	$ 50,449	$ 52,082