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Condensed Consolidated Statements of Cash Flows (USD $)
In Thousands, unless otherwise specified
3 Months Ended
Mar. 31, 2015
Mar. 31, 2014
Cash flows from operating activities    
Net loss $ (34,432)us-gaap_ProfitLoss $ (27,754)us-gaap_ProfitLoss
Adjustments to reconcile net loss to net cash used in operating activities    
Non-cash interest expense 1,937us-gaap_PaidInKindInterest 2,144us-gaap_PaidInKindInterest
Depreciation and amortization 1,054us-gaap_DepreciationDepletionAndAmortization 886us-gaap_DepreciationDepletionAndAmortization
Stock-based compensation 3,370mack_AllocatedShareBasedCompensationExpenseIncludingNonEmployees 2,936mack_AllocatedShareBasedCompensationExpenseIncludingNonEmployees
Changes in operating assets and liabilities    
Purchased premiums and interest on available-for-sale securities   (1)mack_PurchasedPremiumsAndInterestOnAvailableForSaleSecurities
Accounts receivable (935)us-gaap_IncreaseDecreaseInReceivables (6,298)us-gaap_IncreaseDecreaseInReceivables
Accounts payable, accrued expenses and other 4,649us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities (4,549)us-gaap_IncreaseDecreaseInAccountsPayableAndAccruedLiabilities
Deferred revenues (12,222)us-gaap_IncreaseDecreaseInDeferredRevenue (1,838)us-gaap_IncreaseDecreaseInDeferredRevenue
Other assets and liabilities, net 1,500us-gaap_IncreaseDecreaseInOtherOperatingCapitalNet 3,087us-gaap_IncreaseDecreaseInOtherOperatingCapitalNet
Net cash used in operating activities (35,079)us-gaap_NetCashProvidedByUsedInOperatingActivitiesContinuingOperations (31,387)us-gaap_NetCashProvidedByUsedInOperatingActivitiesContinuingOperations
Cash flows from investing activities    
Purchases of available-for-sale securities   (5,100)us-gaap_PaymentsToAcquireMarketableSecurities
Proceeds from maturities of available-for-sale securities 25,163us-gaap_ProceedsFromSaleAndMaturityOfMarketableSecurities 37,602us-gaap_ProceedsFromSaleAndMaturityOfMarketableSecurities
Purchases of property and equipment (1,204)us-gaap_PaymentsToAcquirePropertyPlantAndEquipment (1,438)us-gaap_PaymentsToAcquirePropertyPlantAndEquipment
Net cash provided by investing activities 23,959us-gaap_NetCashProvidedByUsedInInvestingActivitiesContinuingOperations 31,064us-gaap_NetCashProvidedByUsedInInvestingActivitiesContinuingOperations
Cash flows from financing activities    
Proceeds from exercise of common stock options and warrants 3,136mack_ProceedsFromExerciseOfStockOptionAndWarrants 2,134mack_ProceedsFromExerciseOfStockOptionAndWarrants
Proceeds from issuance of preferred stock of Silver Creek Pharmaceuticals, Inc. 1,129us-gaap_ProceedsFromIssuanceOfPreferredStockAndPreferenceStock  
Net cash provided by financing activities 4,265us-gaap_NetCashProvidedByUsedInFinancingActivitiesContinuingOperations 2,134us-gaap_NetCashProvidedByUsedInFinancingActivitiesContinuingOperations
Net (decrease) increase in cash and cash equivalents (6,855)us-gaap_NetCashProvidedByUsedInContinuingOperations 1,811us-gaap_NetCashProvidedByUsedInContinuingOperations
Cash and cash equivalents, beginning of period 35,688us-gaap_CashAndCashEquivalentsAtCarryingValue 65,086us-gaap_CashAndCashEquivalentsAtCarryingValue
Cash and cash equivalents, end of period 28,833us-gaap_CashAndCashEquivalentsAtCarryingValue 66,897us-gaap_CashAndCashEquivalentsAtCarryingValue
Non-cash investing and financing activities    
Disposal of fully depreciated assets 4us-gaap_PropertyPlantAndEquipmentDisposals 409us-gaap_PropertyPlantAndEquipmentDisposals
Property and equipment in accounts payable and accrued expenses 1,177us-gaap_CapitalExpendituresIncurredButNotYetPaid  
Receivables related to stock option exercises 200mack_ReceivablesFromStockOptionExercises  
Supplemental disclosure of cash flows    
Cash paid for interest $ 3,868us-gaap_InterestPaid $ 3,836us-gaap_InterestPaid