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License and Collaboration Agreements - Schedule of Revenue Recognized and Assets and Liabilities under Collaborative Arrangements (Detail) (USD $)
In Thousands, unless otherwise specified
3 Months Ended 9 Months Ended
Sep. 30, 2014
Sep. 30, 2013
Sep. 30, 2014
Sep. 30, 2013
Dec. 31, 2013
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]          
Total $ 28,002 $ 6,856 $ 68,851 $ 39,963  
License and Collaboration Agreements [Member] | Sanofi [Member]
         
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]          
Upfront payment 13,415 1,250 27,933 3,750  
Milestone payments 5,590 521 11,639 1,562  
Development services 2,953 4,521 16,694 30,794  
Manufacturing services and other 6,044 564 12,585 3,304  
Total 28,002 6,856 68,851 39,410  
Accounts receivable, billed 1,387   1,387   2,357
Accounts receivable, unbilled 302   302   3,417
Deferred revenue $ 21,236   $ 21,236   $ 73,392