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License and Collaboration Agreements - Schedule of Revenue Recognized and Assets and Liabilities under Collaborative Arrangements (Detail) (USD $)
In Thousands, unless otherwise specified
3 Months Ended 6 Months Ended
Jun. 30, 2014
Jun. 30, 2013
Jun. 30, 2014
Jun. 30, 2013
Dec. 31, 2013
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]          
Total $ 27,815 $ 18,452 $ 40,849 $ 33,107  
License and Collaboration Agreements [Member] | Sanofi [Member]
         
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]          
Upfront payment 13,268 1,250 14,518 2,500  
Milestone payments 5,529 521 6,049 1,042  
Development services 3,040 14,682 13,740 26,272  
Manufacturing services and other 5,978 1,999 6,542 2,740  
Total 27,815 18,452 40,849 32,554  
Accounts receivable, billed 3,390   3,390   2,357
Accounts receivable, unbilled 2,938   2,938   3,417
Deferred revenue $ 46,283   $ 46,283   $ 73,392