License and Collaboration Agreements (Tables)

9 Months Ended

Sep. 30, 2013

License and Collaboration Agreements

Schedule of revenue recognized and assets and liabilities under collaborative arrangements

	Three months ended September 30,				Nine months ended September 30,
(in thousands)	2012		2013		2012		2013
Upfront payment	$	1,250	$	1,250	$	3,750	$	3,750
Milestone payments	521		521		2,454		1,562
Development services	8,598		4,521		25,900		30,794
Manufacturing services and other	935		564		2,562		3,304
Total	$	11,304	$	6,856	$	34,666	$	39,410

(in thousands)	December 31, 2012		September 30, 2013
Accounts receivable, billed	$	1,577	$7,212
Accounts receivable, unbilled	7,690		1,623
Deferred revenue	79,913		75,726