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Stock-Based Compensation (Details 2) (USD $) In Thousands, unless otherwise specified	3 Months Ended		9 Months Ended
	Sep. 30, 2012	Sep. 30, 2011	Sep. 30, 2012	Sep. 30, 2011
Stock-based compensation
Stock-based compensation expense for employee awards	$ 1,800	$ 1,426	$ 4,516	$ 5,107
Stock-based compensation expense for non-employee awards	383	363	416	466
Total stock-based compensation expense	2,183	1,789	4,932	5,573
Research and development
Stock-based compensation
Stock-based compensation expense for employee awards	1,119	1,021	2,972	2,654
General and administrative
Stock-based compensation
Stock-based compensation expense for employee awards	$ 681	$ 405	$ 1,544	$ 2,453

Represents the expense recognized during the period arising from equity-based compensation arrangements (for example, shares of stock, unit, stock options or other equity instruments) with employees, directors and certain consultants qualifying for treatment as employees.

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