License and Collaboration Agreements (Tables)

9 Months Ended

Sep. 30, 2012

License and Collaboration Agreements

Schedule of revenue recognized and accounts receivable and deferred revenue under collaborative arrangements

	Three months ended September 30,				Nine months ended September 30,
(in thousands)	2011		2012		2011		2012
Upfront payment	$	1,250	$	1,250	$	3,750	$	3,750
Milestone payment	208		521		625		2,454
Development services	6,584		8,598		15,976		25,900
Manufacturing services and other	520		935		1,214		2,562
Total	$	8,562	$	11,304	$	21,565	$	34,666

(in thousands)	December 31, 2011		September 30, 2012
Accounts receivable, billed	$	4,478	$	1,562
Accounts receivable, unbilled	2,925		4,471
Deferred revenue	84,466		82,522