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Stock-Based Compensation (Details 2) (USD $) In Thousands, unless otherwise specified	3 Months Ended		6 Months Ended
	Jun. 30, 2012	Jun. 30, 2011	Jun. 30, 2012	Jun. 30, 2011
Stock-based compensation
Stock-based compensation expense for employee awards	$ 1,377	$ 2,708	$ 2,715	$ 3,681
Stock-based compensation expense for non-employee awards	33	56	34	103
Total stock-based compensation expense	1,410	2,764	2,749	3,784
Research and development
Stock-based compensation
Stock-based compensation expense for employee awards	945	933	1,853	1,633
General and administrative
Stock-based compensation
Stock-based compensation expense for employee awards	$ 432	$ 1,775	$ 862	$ 2,048

Represents the expense recognized during the period arising from equity-based compensation arrangements (for example, shares of stock, unit, stock options or other equity instruments) with employees, directors and certain consultants qualifying for treatment as employees.

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