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Stock-Based Compensation (Details 2) (USD $) In Thousands, unless otherwise specified	12 Months Ended
	Dec. 31, 2012	Dec. 31, 2011	Dec. 31, 2010
Allocation of recognized period cost
Stock-based compensation expense for employee awards	$ 6,744	$ 6,472	$ 4,493
Stock-based compensation expense for non-employee awards	145	480	58
Total stock-based compensation expense	6,889	6,952	4,551
Research and development
Allocation of recognized period cost
Stock-based compensation expense for employee awards	4,234	3,597	2,787
General and administrative
Allocation of recognized period cost
Stock-based compensation expense for employee awards	$ 2,510	$ 2,875	$ 1,706

Represents the expense recognized during the period arising from equity-based compensation arrangements (for example, shares of stock, unit, stock options or other equity instruments) with employees, directors and certain consultants qualifying for treatment as employees.

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