License and Collaboration Agreements (Tables)

12 Months Ended

Dec. 31, 2012

License and Collaboration Agreements

Schedule of revenue recognized and assets and liabilities under collaborative arrangements

	Years ended December 31,
(in thousands)	2010		2011		2012
Upfront payment	$	5,000	$	5,000	$	5,000
Milestone payment		949		2,616		2,975
Development services		13,279		25,053		36,905
Manufacturing services and other		630		1,456		3,307
Total	$	19,858	$	34,125	$	48,187

	December 31,
(in thousands)	2011		2012
Accounts receivable, billed	$	4,478	$	1,577
Accounts receivable, unbilled		2,925		7,690
Deferred revenues		84,466		79,913