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License and Collaboration Agreements - Additional Information (Detail) - USD ($)
12 Months Ended
Apr. 03, 2017
Nov. 10, 2009
Dec. 31, 2016
Dec. 31, 2015
Dec. 31, 2014
Dec. 31, 2013
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]            
Agreement termination scheduled date     Dec. 17, 2014      
Assets maintained related to Sanofi Agreement     $ 81,483,000 $ 234,880,000    
Liabilities maintained related to Sanofi Agreement     334,142,000 418,569,000    
Ipsen [Member] | Asset Sale Agreement [Member] | Development and Commercialization Milestones [Member] | Subsequent Event [Member]            
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]            
Maximum amount of milestone payments that can be received $ 33,000,000          
Ipsen [Member] | Asset Sale Agreement [Member] | Sale Milestones in Major European Countries [Member] | Subsequent Event [Member]            
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]            
Potential milestone payments receivable 18,000,000          
Ipsen [Member] | Asset Sale Agreement [Member] | Sale Milestones in Major Non-European and Non-Asian Country [Member] | Subsequent Event [Member]            
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]            
Potential milestone payments receivable 5,000,000          
Ipsen [Member] | Asset Sale Agreement [Member] | Clinical Trials in Lung Cancer [Member] | Subsequent Event [Member]            
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]            
Potential milestone payments receivable $ 10,000,000          
Sanofi [Member]            
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]            
Upfront license fee received   $ 60,000,000        
Milestone license fee received     25,000,000      
Expected development period from the effective date of agreement   12 years        
License and collaboration revenues     0 0    
Assets maintained related to Sanofi Agreement     0 0    
Liabilities maintained related to Sanofi Agreement     $ 0 $ 0    
Sanofi [Member] | License and Collaboration Agreements [Member]            
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]            
License and collaboration revenues         $ 92,296,000  
Recognized revenue related to excess spending         $ 5,800,000  
Spending in excess of budget           $ 10,100,000