Property and Equipment, Net

12 Months Ended

Dec. 31, 2016

Property Plant And Equipment [Abstract]

9. Property and Equipment, Net

Property and equipment, net as of December 31, 2016 and 2015 consisted of the following:

	December 31,
(in thousands)	2016			2015
Lab equipment	$	17,537		$	16,325
IT equipment		8,509			7,733
Leasehold improvements		20,633			20,507
Furniture and fixtures		626			635
Construction in process		378			2,243
Total property and equipment, gross		47,683			47,443
Less: Accumulated depreciation		(33,471	)		(27,342	)
Total property and equipment, net	$	14,212		$	20,101

Depreciation expense was $6.5 million, $4.8 million and $3.7 million for the years ended December 31, 2016, 2015 and 2014, respectively. Capitalized interest costs were insignificant for the years ended December 31, 2016, 2015 and 2014.

During the year ended December 31, 2016, the Company recognized a $0.5 million charge related to the disposal of property and equipment. There were no significant losses recognized related to the disposal of property and equipment during the years ended December 31, 2015 or 2014.