X0306 4 2013-12-19 0 0001274644 Ocera Therapeutics, Inc. OCRX 0001580787 Shah Pratik C/O OCERA THERAPEUTICS, INC. 525 UNIVERSITY AVENUE, SUITE 610 PALO ALTO CA 94301 1 0 0 0 Stock Option (Right to Buy) 7.85 2013-08-30 4 A 0 20000 0 A 2023-08-30 Common Stock 20000 20000 D Option to purchase Common Stock granted by the Issuer pursuant to the Issuer's Second Amended and Restated 2011 Stock Option and Incentive Plan (the "Plan"), qualified under Rule 16b-3(d). The Issuer granted the option on August 30, 2013, subject to stockholder approval of the Plan, which was obtained on December 19, 2013. The option shall vest and become exercisable with respect to 25% of the shares covered by the grant on August 30, 2014, subject to the Reporting Person's continued service to the Issuer through such date, with the balance to vest in equal monthly installments over the next succeeding three year period, subject to the Reporting Person's continued service to the Issuer through each such date. Exhibit 24.1 - Power of Attorney /s/ Jeryl L. Hilleman, Attorney-In-Fact 2013-12-23