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    <nameOfIssuer>ABBOTT LABS</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
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    <nameOfIssuer>ABBVIE INC</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>00287Y109</cusip>
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      <Sole>14800</Sole>
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    <nameOfIssuer>ALNYLAM PHARMACUETCL</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>02043Q107</cusip>
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      <Sole>2568</Sole>
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    <titleOfClass>COM</titleOfClass>
    <cusip>031162100</cusip>
    <value>3146697</value>
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    <nameOfIssuer>AMICUS THERAPEUTICS</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>03152W109</cusip>
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    <nameOfIssuer>ANAPTYSBIO INC</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>032724106</cusip>
    <value>1862580</value>
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    <nameOfIssuer>ARCUS BIOSCIENCES</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>03969F109</cusip>
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      <Sole>21000</Sole>
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    <nameOfIssuer>ARGENX SE SPN</nameOfIssuer>
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    <cusip>04016X101</cusip>
    <value>2251734</value>
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      <None>409</None>
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    <nameOfIssuer>ARRIVENT BIOPHARMA</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>04272N102</cusip>
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      <Sole>32840</Sole>
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      <None>2740</None>
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    <nameOfIssuer>ARS PHARMACEUTICALS</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>82835W108</cusip>
    <value>1147948</value>
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      <Sole>60307</Sole>
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      <None>5478</None>
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    <nameOfIssuer>ASCENDIS PHARMA A S</nameOfIssuer>
    <titleOfClass>SP ADR</titleOfClass>
    <cusip>04351P101</cusip>
    <value>599095</value>
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      <sshPrnamt>3471</sshPrnamt>
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      <Sole>2800</Sole>
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      <None>671</None>
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    <nameOfIssuer>ASTRAZENECA</nameOfIssuer>
    <titleOfClass>SP ADR</titleOfClass>
    <cusip>046353108</cusip>
    <value>1302563</value>
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      <Sole>14650</Sole>
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    <nameOfIssuer>AXSOME THERAPEUTIC</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>05464T104</cusip>
    <value>106478</value>
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      <Sole>820</Sole>
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    <nameOfIssuer>BEONE MEDICINES LTD</nameOfIssuer>
    <titleOfClass>SP ADR</titleOfClass>
    <cusip>07725L102</cusip>
    <value>1867812</value>
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      <sshPrnamt>7716</sshPrnamt>
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    <votingAuthority>
      <Sole>5585</Sole>
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      <None>2131</None>
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    <nameOfIssuer>BICARA THERAPEUTICS</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>055477103</cusip>
    <value>1870960</value>
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      <Sole>0</Sole>
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    <nameOfIssuer>BIOGEN INC</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>09062X103</cusip>
    <value>298276</value>
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      <sshPrnamt>2375</sshPrnamt>
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      <Sole>1850</Sole>
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      <None>525</None>
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    <nameOfIssuer>BIOMARIN PHARMAC INC</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>09061G101</cusip>
    <value>1293444</value>
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    <votingAuthority>
      <Sole>20800</Sole>
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    <nameOfIssuer>BIONTECH SE</nameOfIssuer>
    <titleOfClass>SP ADR</titleOfClass>
    <cusip>09075V102</cusip>
    <value>1720555</value>
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      <sshPrnamt>16160</sshPrnamt>
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      <Sole>14900</Sole>
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      <None>1260</None>
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    <nameOfIssuer>BOSTON SCIENTIFIC</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>101137107</cusip>
    <value>2269144</value>
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      <sshPrnamt>21126</sshPrnamt>
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      <Sole>21126</Sole>
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      <None>0</None>
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    <nameOfIssuer>BOUNDLESS BIO INC</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>10170A100</cusip>
    <value>685360</value>
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    <votingAuthority>
      <Sole>678574</Sole>
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      <None>0</None>
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    <nameOfIssuer>BRIDGEBIO PHARMA INC</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>10806X102</cusip>
    <value>694550</value>
    <shrsOrPrnAmt>
      <sshPrnamt>16085</sshPrnamt>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>12500</Sole>
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      <None>3585</None>
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    <nameOfIssuer>BRISTOL MYERS SQUIBB</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>110122108</cusip>
    <value>499932</value>
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      <sshPrnamt>10800</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>10800</Sole>
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      <None>0</None>
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    <nameOfIssuer>CARIS LIFE SCIENCES</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>142152107</cusip>
    <value>223112</value>
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      <sshPrnamt>8350</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>8350</Sole>
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      <None>0</None>
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    <nameOfIssuer>CENTENE CORP</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>15135B101</cusip>
    <value>678500</value>
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      <sshPrnamt>12500</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>12500</Sole>
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      <None>0</None>
    </votingAuthority>
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    <nameOfIssuer>CONTINEUM THERAPEUTI</nameOfIssuer>
    <titleOfClass>CL A</titleOfClass>
    <cusip>21217B100</cusip>
    <value>3179124</value>
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      <sshPrnamt>800787</sshPrnamt>
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      <Sole>800787</Sole>
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      <None>0</None>
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    <nameOfIssuer>CRISPR THERAPEUTICS</nameOfIssuer>
    <titleOfClass>NAMEN AKT</titleOfClass>
    <cusip>H17182108</cusip>
    <value>123546</value>
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      <sshPrnamt>2540</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>2000</Sole>
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      <None>540</None>
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    <nameOfIssuer>CVRX INC</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>126638105</cusip>
    <value>432180</value>
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      <sshPrnamt>73500</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>73500</Sole>
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      <None>0</None>
    </votingAuthority>
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    <nameOfIssuer>CYTOKINETICS INC</nameOfIssuer>
    <titleOfClass>COM NEW</titleOfClass>
    <cusip>23282W605</cusip>
    <value>387328</value>
    <shrsOrPrnAmt>
      <sshPrnamt>11723</sshPrnamt>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>9150</Sole>
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      <None>2573</None>
    </votingAuthority>
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    <nameOfIssuer>DANAHER CORP</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>235851102</cusip>
    <value>2091354</value>
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      <sshPrnamt>10575</sshPrnamt>
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    <votingAuthority>
      <Sole>10575</Sole>
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      <None>0</None>
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    <nameOfIssuer>DEXCOM INC</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>252131107</cusip>
    <value>1152228</value>
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      <sshPrnamt>13200</sshPrnamt>
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    <votingAuthority>
      <Sole>13200</Sole>
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      <None>0</None>
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    <nameOfIssuer>EDWARDS LIFESCIENCE</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>28176E108</cusip>
    <value>1173150</value>
    <shrsOrPrnAmt>
      <sshPrnamt>15000</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <votingAuthority>
      <Sole>15000</Sole>
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      <None>0</None>
    </votingAuthority>
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    <nameOfIssuer>GILEAD SCIENCES INC</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>375558103</cusip>
    <value>2183030</value>
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      <sshPrnamt>19690</sshPrnamt>
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    <votingAuthority>
      <Sole>15330</Sole>
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      <None>4360</None>
    </votingAuthority>
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    <nameOfIssuer>GLOBUS MED INC</nameOfIssuer>
    <titleOfClass>CL A</titleOfClass>
    <cusip>379577208</cusip>
    <value>796770</value>
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      <sshPrnamt>13500</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>13500</Sole>
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      <None>0</None>
    </votingAuthority>
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    <nameOfIssuer>HINGE HEALTH INC</nameOfIssuer>
    <titleOfClass>CL A</titleOfClass>
    <cusip>433313103</cusip>
    <value>476411</value>
    <shrsOrPrnAmt>
      <sshPrnamt>9206</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>9206</Sole>
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      <None>0</None>
    </votingAuthority>
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    <nameOfIssuer>ILLUMINA INC</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>452327109</cusip>
    <value>265431</value>
    <shrsOrPrnAmt>
      <sshPrnamt>2782</sshPrnamt>
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    <votingAuthority>
      <Sole>2132</Sole>
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      <None>650</None>
    </votingAuthority>
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  <infoTable>
    <nameOfIssuer>IMMATICS NV</nameOfIssuer>
    <titleOfClass>SHS</titleOfClass>
    <cusip>N44445109</cusip>
    <value>1787613</value>
    <shrsOrPrnAmt>
      <sshPrnamt>332270</sshPrnamt>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>0</Sole>
      <Shared>0</Shared>
      <None>332270</None>
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    <nameOfIssuer>INCYTE CORPORATION</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>45337C102</cusip>
    <value>412686</value>
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      <sshPrnamt>6060</sshPrnamt>
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    <votingAuthority>
      <Sole>4700</Sole>
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      <None>1360</None>
    </votingAuthority>
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    <nameOfIssuer>INSMED INC</nameOfIssuer>
    <titleOfClass>COM PAR $.01</titleOfClass>
    <cusip>457669307</cusip>
    <value>1497523</value>
    <shrsOrPrnAmt>
      <sshPrnamt>14880</sshPrnamt>
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    <investmentDiscretion>SOLE</investmentDiscretion>
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      <Sole>12950</Sole>
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      <None>1930</None>
    </votingAuthority>
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    <nameOfIssuer>INSTIL BIO INC</nameOfIssuer>
    <titleOfClass>COM NEW</titleOfClass>
    <cusip>45783C200</cusip>
    <value>1795963</value>
    <shrsOrPrnAmt>
      <sshPrnamt>86220</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>15850</Sole>
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      <None>70370</None>
    </votingAuthority>
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    <nameOfIssuer>INTUITIVE SURGIC INC</nameOfIssuer>
    <titleOfClass>COM NEW</titleOfClass>
    <cusip>46120E602</cusip>
    <value>2852903</value>
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      <sshPrnamt>5250</sshPrnamt>
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    <votingAuthority>
      <Sole>5250</Sole>
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      <None>0</None>
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    <nameOfIssuer>IO BIOTECH INC</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>449778109</cusip>
    <value>163590</value>
    <shrsOrPrnAmt>
      <sshPrnamt>117691</sshPrnamt>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>91441</Sole>
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      <None>26250</None>
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    <nameOfIssuer>IONIS PHARMACEUTICAL</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>462222100</cusip>
    <value>363690</value>
    <shrsOrPrnAmt>
      <sshPrnamt>9205</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>7200</Sole>
      <Shared>0</Shared>
      <None>2005</None>
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    <nameOfIssuer>JAZZ PHARMA PLC</nameOfIssuer>
    <titleOfClass>SHS USD</titleOfClass>
    <cusip>G50871105</cusip>
    <value>241317</value>
    <shrsOrPrnAmt>
      <sshPrnamt>2274</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>1750</Sole>
      <Shared>0</Shared>
      <None>524</None>
    </votingAuthority>
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    <nameOfIssuer>JOHNSON &amp; JOHNSON</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>478160104</cusip>
    <value>2948075</value>
    <shrsOrPrnAmt>
      <sshPrnamt>19300</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>19300</Sole>
      <Shared>0</Shared>
      <None>0</None>
    </votingAuthority>
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    <nameOfIssuer>KESTRA MED TECHNOLOG</nameOfIssuer>
    <titleOfClass>SHS</titleOfClass>
    <cusip>G52441105</cusip>
    <value>580300</value>
    <shrsOrPrnAmt>
      <sshPrnamt>35000</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>35000</Sole>
      <Shared>0</Shared>
      <None>0</None>
    </votingAuthority>
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    <nameOfIssuer>KURA ONCOLOGY INC</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>50127T109</cusip>
    <value>1867010</value>
    <shrsOrPrnAmt>
      <sshPrnamt>323572</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>0</Sole>
      <Shared>0</Shared>
      <None>323572</None>
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    <nameOfIssuer>LEGEND BIOTECH CORP</nameOfIssuer>
    <titleOfClass>SP ADR</titleOfClass>
    <cusip>52490G102</cusip>
    <value>696562</value>
    <shrsOrPrnAmt>
      <sshPrnamt>19627</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>8550</Sole>
      <Shared>0</Shared>
      <None>11077</None>
    </votingAuthority>
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    <nameOfIssuer>LENZ THERAPEUTICS</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>52635N103</cusip>
    <value>28643051</value>
    <shrsOrPrnAmt>
      <sshPrnamt>977245</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>977245</Sole>
      <Shared>0</Shared>
      <None>0</None>
    </votingAuthority>
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    <nameOfIssuer>ELI LILLY &amp; CO</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>532457108</cusip>
    <value>6997061</value>
    <shrsOrPrnAmt>
      <sshPrnamt>8976</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>8976</Sole>
      <Shared>0</Shared>
      <None>0</None>
    </votingAuthority>
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    <nameOfIssuer>MADRIGAL PHARMACEUTI</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>558868105</cusip>
    <value>220927</value>
    <shrsOrPrnAmt>
      <sshPrnamt>730</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>570</Sole>
      <Shared>0</Shared>
      <None>160</None>
    </votingAuthority>
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  <infoTable>
    <nameOfIssuer>MBX BIOSCIENCES INC</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>55287L101</cusip>
    <value>2188723</value>
    <shrsOrPrnAmt>
      <sshPrnamt>191825</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>0</Sole>
      <Shared>0</Shared>
      <None>191825</None>
    </votingAuthority>
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    <nameOfIssuer>MEDPACE HOLDINGS</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>58506Q109</cusip>
    <value>166660</value>
    <shrsOrPrnAmt>
      <sshPrnamt>531</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>415</Sole>
      <Shared>0</Shared>
      <None>116</None>
    </votingAuthority>
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    <nameOfIssuer>MERCK &amp; CO INC</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>58933Y105</cusip>
    <value>1666294</value>
    <shrsOrPrnAmt>
      <sshPrnamt>20900</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>20900</Sole>
      <Shared>0</Shared>
      <None>0</None>
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    <nameOfIssuer>MERUS B V</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>N5749R100</cusip>
    <value>824505</value>
    <shrsOrPrnAmt>
      <sshPrnamt>15675</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>14000</Sole>
      <Shared>0</Shared>
      <None>1675</None>
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    <nameOfIssuer>MINERALYS THERAPEUTI</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>603170101</cusip>
    <value>5174075</value>
    <shrsOrPrnAmt>
      <sshPrnamt>382415</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>378385</Sole>
      <Shared>0</Shared>
      <None>4030</None>
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    <nameOfIssuer>MODERNA INC</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>60770K107</cusip>
    <value>154504</value>
    <shrsOrPrnAmt>
      <sshPrnamt>5600</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>4350</Sole>
      <Shared>0</Shared>
      <None>1250</None>
    </votingAuthority>
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  <infoTable>
    <nameOfIssuer>MOONLAKE IMMUNOTHERA</nameOfIssuer>
    <titleOfClass>CLASS A ORD</titleOfClass>
    <cusip>61559X104</cusip>
    <value>713098</value>
    <shrsOrPrnAmt>
      <sshPrnamt>15108</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>13687</Sole>
      <Shared>0</Shared>
      <None>1421</None>
    </votingAuthority>
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  <infoTable>
    <nameOfIssuer>NEUROCRINE BIOSCIENC</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>64125C109</cusip>
    <value>372042</value>
    <shrsOrPrnAmt>
      <sshPrnamt>2960</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>2300</Sole>
      <Shared>0</Shared>
      <None>660</None>
    </votingAuthority>
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    <nameOfIssuer>OMADA HEALTH INC</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>68170A108</cusip>
    <value>631350</value>
    <shrsOrPrnAmt>
      <sshPrnamt>34500</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>34500</Sole>
      <Shared>0</Shared>
      <None>0</None>
    </votingAuthority>
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  <infoTable>
    <nameOfIssuer>ORIC PHARMACEUTICA</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>68622P109</cusip>
    <value>2349573</value>
    <shrsOrPrnAmt>
      <sshPrnamt>231485</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>16000</Sole>
      <Shared>0</Shared>
      <None>215485</None>
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  <infoTable>
    <nameOfIssuer>PALVELLA THERAPEUTIC</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>697947109</cusip>
    <value>2155162</value>
    <shrsOrPrnAmt>
      <sshPrnamt>95615</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>0</Sole>
      <Shared>0</Shared>
      <None>95615</None>
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    <nameOfIssuer>PFIZER INC</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>717081103</cusip>
    <value>1870116</value>
    <shrsOrPrnAmt>
      <sshPrnamt>77150</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>77150</Sole>
      <Shared>0</Shared>
      <None>0</None>
    </votingAuthority>
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  <infoTable>
    <nameOfIssuer>PTC THERAPEUTICS</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>69366J200</cusip>
    <value>416849</value>
    <shrsOrPrnAmt>
      <sshPrnamt>8535</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>6650</Sole>
      <Shared>0</Shared>
      <None>1885</None>
    </votingAuthority>
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  <infoTable>
    <nameOfIssuer>RADNET INC</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>750491102</cusip>
    <value>711375</value>
    <shrsOrPrnAmt>
      <sshPrnamt>12500</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>12500</Sole>
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      <None>0</None>
    </votingAuthority>
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  <infoTable>
    <nameOfIssuer>RAPPORT THERAPEUTICS</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>75383L102</cusip>
    <value>2045008</value>
    <shrsOrPrnAmt>
      <sshPrnamt>179860</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>0</Sole>
      <Shared>0</Shared>
      <None>179860</None>
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  <infoTable>
    <nameOfIssuer>RECURSION PHARMACEUT</nameOfIssuer>
    <titleOfClass>CL A</titleOfClass>
    <cusip>75629V104</cusip>
    <value>58190</value>
    <shrsOrPrnAmt>
      <sshPrnamt>11500</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>9100</Sole>
      <Shared>0</Shared>
      <None>2400</None>
    </votingAuthority>
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  <infoTable>
    <nameOfIssuer>REGENERON PHARMCTCLS</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>75886F107</cusip>
    <value>1455825</value>
    <shrsOrPrnAmt>
      <sshPrnamt>2773</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>2163</Sole>
      <Shared>0</Shared>
      <None>610</None>
    </votingAuthority>
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  <infoTable>
    <nameOfIssuer>REPLIMUNE GROUP INC</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>76029N106</cusip>
    <value>2152029</value>
    <shrsOrPrnAmt>
      <sshPrnamt>231650</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>23000</Sole>
      <Shared>0</Shared>
      <None>208650</None>
    </votingAuthority>
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  <infoTable>
    <nameOfIssuer>REVOLUTION MEDICIN</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>76155X100</cusip>
    <value>229570</value>
    <shrsOrPrnAmt>
      <sshPrnamt>6240</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>4900</Sole>
      <Shared>0</Shared>
      <None>1340</None>
    </votingAuthority>
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  <infoTable>
    <nameOfIssuer>ROIVANT SCIENCES LTD</nameOfIssuer>
    <titleOfClass>SHS</titleOfClass>
    <cusip>G76279101</cusip>
    <value>563579</value>
    <shrsOrPrnAmt>
      <sshPrnamt>50007</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>39000</Sole>
      <Shared>0</Shared>
      <None>11007</None>
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  <infoTable>
    <nameOfIssuer>ROYALTY PHARMA PLC</nameOfIssuer>
    <titleOfClass>SHS CLASS A</titleOfClass>
    <cusip>G7709Q104</cusip>
    <value>334358</value>
    <shrsOrPrnAmt>
      <sshPrnamt>9280</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>7200</Sole>
      <Shared>0</Shared>
      <None>2080</None>
    </votingAuthority>
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  <infoTable>
    <nameOfIssuer>SCHOLAR ROCK HLDG</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>80706P103</cusip>
    <value>367660</value>
    <shrsOrPrnAmt>
      <sshPrnamt>10380</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>8300</Sole>
      <Shared>0</Shared>
      <None>2080</None>
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  </infoTable>
  <infoTable>
    <nameOfIssuer>SOLID BIOSCIENCES</nameOfIssuer>
    <titleOfClass>COM NEW</titleOfClass>
    <cusip>83422E204</cusip>
    <value>2053095</value>
    <shrsOrPrnAmt>
      <sshPrnamt>421580</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>0</Sole>
      <Shared>0</Shared>
      <None>421580</None>
    </votingAuthority>
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  <infoTable>
    <nameOfIssuer>STRUCTURE THERAPEU</nameOfIssuer>
    <titleOfClass>SP ADR</titleOfClass>
    <cusip>86366E106</cusip>
    <value>1065393</value>
    <shrsOrPrnAmt>
      <sshPrnamt>51369</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>31250</Sole>
      <Shared>0</Shared>
      <None>20119</None>
    </votingAuthority>
  </infoTable>
  <infoTable>
    <nameOfIssuer>STRYKER CORP</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>863667101</cusip>
    <value>1545250</value>
    <shrsOrPrnAmt>
      <sshPrnamt>3900</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>3900</Sole>
      <Shared>0</Shared>
      <None>0</None>
    </votingAuthority>
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  <infoTable>
    <nameOfIssuer>SUMMIT THERAPEUTICS</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>86627T108</cusip>
    <value>1387882</value>
    <shrsOrPrnAmt>
      <sshPrnamt>65220</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>57700</Sole>
      <Shared>0</Shared>
      <None>7520</None>
    </votingAuthority>
  </infoTable>
  <infoTable>
    <nameOfIssuer>SYNDAX PHARMACEUTI</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>87164F105</cusip>
    <value>592805</value>
    <shrsOrPrnAmt>
      <sshPrnamt>63300</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>58300</Sole>
      <Shared>0</Shared>
      <None>5000</None>
    </votingAuthority>
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  <infoTable>
    <nameOfIssuer>TARSUS PHARMACEUTICA</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>87650L103</cusip>
    <value>750853</value>
    <shrsOrPrnAmt>
      <sshPrnamt>18535</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>16420</Sole>
      <Shared>0</Shared>
      <None>2115</None>
    </votingAuthority>
  </infoTable>
  <infoTable>
    <nameOfIssuer>TECTONIC THERAPEUTIC</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>878972108</cusip>
    <value>1966534</value>
    <shrsOrPrnAmt>
      <sshPrnamt>98970</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>0</Sole>
      <Shared>0</Shared>
      <None>98970</None>
    </votingAuthority>
  </infoTable>
  <infoTable>
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