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    <nameOfIssuer>ABBOTT LABS</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>002824100</cusip>
    <value>7594610</value>
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      <Sole>68998</Sole>
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      <None>0</None>
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    <nameOfIssuer>ABBVIE INC</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>00287Y109</cusip>
    <value>7175111</value>
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      <sshPrnamt>46300</sshPrnamt>
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    <votingAuthority>
      <Sole>46300</Sole>
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      <None>0</None>
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    <nameOfIssuer>ACADIA PHARMACEUTCLS</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>004225108</cusip>
    <value>471529</value>
    <shrsOrPrnAmt>
      <sshPrnamt>15060</sshPrnamt>
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    <votingAuthority>
      <Sole>10000</Sole>
      <Shared>0</Shared>
      <None>5060</None>
    </votingAuthority>
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    <nameOfIssuer>ACELYRIN INC</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>00445A100</cusip>
    <value>2428596</value>
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      <sshPrnamt>325549</sshPrnamt>
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      <Sole>0</Sole>
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      <None>325549</None>
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    <nameOfIssuer>ALLAKOS INC</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>01671P100</cusip>
    <value>2054000</value>
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      <sshPrnamt>752381</sshPrnamt>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>0</Sole>
      <Shared>0</Shared>
      <None>752381</None>
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    <nameOfIssuer>ALNYLAM PHARMACUETCL</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>02043Q107</cusip>
    <value>4333522</value>
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      <sshPrnamt>22640</sshPrnamt>
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    <votingAuthority>
      <Sole>20100</Sole>
      <Shared>0</Shared>
      <None>2540</None>
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    <nameOfIssuer>ALTIMMUNE INC</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>02155H200</cusip>
    <value>1921500</value>
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      <sshPrnamt>170800</sshPrnamt>
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    <votingAuthority>
      <Sole>163800</Sole>
      <Shared>0</Shared>
      <None>7000</None>
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    <nameOfIssuer>AMGEN INC</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>031162100</cusip>
    <value>8261854</value>
    <shrsOrPrnAmt>
      <sshPrnamt>28685</sshPrnamt>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>24100</Sole>
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      <None>4585</None>
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    <nameOfIssuer>AMICUS THERAPEUTICS</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>03152W109</cusip>
    <value>2224552</value>
    <shrsOrPrnAmt>
      <sshPrnamt>156769</sshPrnamt>
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    <votingAuthority>
      <Sole>146844</Sole>
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      <None>9925</None>
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    <nameOfIssuer>AMYLYX PHARMACEUTIC</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>03237H101</cusip>
    <value>1237290</value>
    <shrsOrPrnAmt>
      <sshPrnamt>84055</sshPrnamt>
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    <votingAuthority>
      <Sole>80090</Sole>
      <Shared>0</Shared>
      <None>3965</None>
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    <nameOfIssuer>ANNEXON INC</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>03589W102</cusip>
    <value>2955136</value>
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      <sshPrnamt>650911</sshPrnamt>
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    <votingAuthority>
      <Sole>0</Sole>
      <Shared>0</Shared>
      <None>650911</None>
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    <nameOfIssuer>APELLIS PHARMACEUTIC</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>03753U106</cusip>
    <value>312469</value>
    <shrsOrPrnAmt>
      <sshPrnamt>5220</sshPrnamt>
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    <votingAuthority>
      <Sole>3500</Sole>
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      <None>1720</None>
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    <nameOfIssuer>ARCUS BIOSCIENCES</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>03969F109</cusip>
    <value>1861009</value>
    <shrsOrPrnAmt>
      <sshPrnamt>97435</sshPrnamt>
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    <votingAuthority>
      <Sole>93525</Sole>
      <Shared>0</Shared>
      <None>3910</None>
    </votingAuthority>
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    <nameOfIssuer>ARGENX SE</nameOfIssuer>
    <titleOfClass>SPN ADR</titleOfClass>
    <cusip>04016X101</cusip>
    <value>3814572</value>
    <shrsOrPrnAmt>
      <sshPrnamt>10027</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>9345</Sole>
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      <None>682</None>
    </votingAuthority>
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    <nameOfIssuer>ARROWHEAD PHARMACEUT</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>04280A100</cusip>
    <value>250369</value>
    <shrsOrPrnAmt>
      <sshPrnamt>8182</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>5500</Sole>
      <Shared>0</Shared>
      <None>2682</None>
    </votingAuthority>
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    <nameOfIssuer>ARVINAS INC</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>04335A105</cusip>
    <value>2716560</value>
    <shrsOrPrnAmt>
      <sshPrnamt>66000</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>0</Sole>
      <Shared>0</Shared>
      <None>66000</None>
    </votingAuthority>
  </infoTable>
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    <nameOfIssuer>ASCENDIS PHARMA A S</nameOfIssuer>
    <titleOfClass>SPN ADR</titleOfClass>
    <cusip>04351P101</cusip>
    <value>559344</value>
    <shrsOrPrnAmt>
      <sshPrnamt>4441</sshPrnamt>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>2940</Sole>
      <Shared>0</Shared>
      <None>1501</None>
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    <nameOfIssuer>ASTRAZENECA</nameOfIssuer>
    <titleOfClass>SPN ADR</titleOfClass>
    <cusip>046353108</cusip>
    <value>1759856</value>
    <shrsOrPrnAmt>
      <sshPrnamt>26130</sshPrnamt>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>17210</Sole>
      <Shared>0</Shared>
      <None>8920</None>
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    <nameOfIssuer>AXONICS INC</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>05465P101</cusip>
    <value>2041144</value>
    <shrsOrPrnAmt>
      <sshPrnamt>32800</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>32800</Sole>
      <Shared>0</Shared>
      <None>0</None>
    </votingAuthority>
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    <nameOfIssuer>BEIGENE LIMITED</nameOfIssuer>
    <titleOfClass>SPN ADR</titleOfClass>
    <cusip>07725L102</cusip>
    <value>676711</value>
    <shrsOrPrnAmt>
      <sshPrnamt>3752</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>2960</Sole>
      <Shared>0</Shared>
      <None>792</None>
    </votingAuthority>
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    <nameOfIssuer>BIOMARIN PHARMAC INC</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>09061G101</cusip>
    <value>4827749</value>
    <shrsOrPrnAmt>
      <sshPrnamt>50070</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>45900</Sole>
      <Shared>0</Shared>
      <None>4170</None>
    </votingAuthority>
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    <nameOfIssuer>BIOGEN INC</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>09062X103</cusip>
    <value>4095553</value>
    <shrsOrPrnAmt>
      <sshPrnamt>15827</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>13352</Sole>
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      <None>2475</None>
    </votingAuthority>
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    <nameOfIssuer>BIONTECH SE</nameOfIssuer>
    <titleOfClass>SPN ADR</titleOfClass>
    <cusip>09075V102</cusip>
    <value>393137</value>
    <shrsOrPrnAmt>
      <sshPrnamt>3725</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>2450</Sole>
      <Shared>0</Shared>
      <None>1275</None>
    </votingAuthority>
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  <infoTable>
    <nameOfIssuer>BIOATLA INC</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>09077B104</cusip>
    <value>1736913</value>
    <shrsOrPrnAmt>
      <sshPrnamt>706062</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>0</Sole>
      <Shared>0</Shared>
      <None>706062</None>
    </votingAuthority>
  </infoTable>
  <infoTable>
    <nameOfIssuer>BLUEPRINT MEDICINES</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>09627Y109</cusip>
    <value>227833</value>
    <shrsOrPrnAmt>
      <sshPrnamt>2470</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>1900</Sole>
      <Shared>0</Shared>
      <None>570</None>
    </votingAuthority>
  </infoTable>
  <infoTable>
    <nameOfIssuer>BOSTON SCIENTIFIC</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>101137107</cusip>
    <value>5288228</value>
    <shrsOrPrnAmt>
      <sshPrnamt>91476</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>91476</Sole>
      <Shared>0</Shared>
      <None>0</None>
    </votingAuthority>
  </infoTable>
  <infoTable>
    <nameOfIssuer>BRIDGEBIO PHARMA INC</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>10806X102</cusip>
    <value>522993</value>
    <shrsOrPrnAmt>
      <sshPrnamt>12955</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
    </shrsOrPrnAmt>
    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>8600</Sole>
      <Shared>0</Shared>
      <None>4355</None>
    </votingAuthority>
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  <infoTable>
    <nameOfIssuer>CONMED CORP</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>207410101</cusip>
    <value>1982131</value>
    <shrsOrPrnAmt>
      <sshPrnamt>18100</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>18100</Sole>
      <Shared>0</Shared>
      <None>0</None>
    </votingAuthority>
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  <infoTable>
    <nameOfIssuer>CYTOKINETICS INC</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>23282W605</cusip>
    <value>585515</value>
    <shrsOrPrnAmt>
      <sshPrnamt>7013</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>4050</Sole>
      <Shared>0</Shared>
      <None>2963</None>
    </votingAuthority>
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  <infoTable>
    <nameOfIssuer>DANAHER CORP</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>235851102</cusip>
    <value>3464317</value>
    <shrsOrPrnAmt>
      <sshPrnamt>14975</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
    </shrsOrPrnAmt>
    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>14975</Sole>
      <Shared>0</Shared>
      <None>0</None>
    </votingAuthority>
  </infoTable>
  <infoTable>
    <nameOfIssuer>DENALI THERAPEUTICS</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>24823R105</cusip>
    <value>276426</value>
    <shrsOrPrnAmt>
      <sshPrnamt>12881</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
    </shrsOrPrnAmt>
    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>8500</Sole>
      <Shared>0</Shared>
      <None>4381</None>
    </votingAuthority>
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  <infoTable>
    <nameOfIssuer>DEXCOM INC</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>252131107</cusip>
    <value>3648246</value>
    <shrsOrPrnAmt>
      <sshPrnamt>29400</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
    </shrsOrPrnAmt>
    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>29400</Sole>
      <Shared>0</Shared>
      <None>0</None>
    </votingAuthority>
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  <infoTable>
    <nameOfIssuer>DR REDDYS LABS LTD</nameOfIssuer>
    <titleOfClass>ADR</titleOfClass>
    <cusip>256135203</cusip>
    <value>313110</value>
    <shrsOrPrnAmt>
      <sshPrnamt>4500</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
    </shrsOrPrnAmt>
    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>4500</Sole>
      <Shared>0</Shared>
      <None>0</None>
    </votingAuthority>
  </infoTable>
  <infoTable>
    <nameOfIssuer>EDGEWISE THERAPEUTIC</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>28036F105</cusip>
    <value>3586143</value>
    <shrsOrPrnAmt>
      <sshPrnamt>327801</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
    </shrsOrPrnAmt>
    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>0</Sole>
      <Shared>0</Shared>
      <None>327801</None>
    </votingAuthority>
  </infoTable>
  <infoTable>
    <nameOfIssuer>EDWARDS LIFESCIENCE</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>28176E108</cusip>
    <value>1669875</value>
    <shrsOrPrnAmt>
      <sshPrnamt>21900</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
    </shrsOrPrnAmt>
    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>21900</Sole>
      <Shared>0</Shared>
      <None>0</None>
    </votingAuthority>
  </infoTable>
  <infoTable>
    <nameOfIssuer>EFFECTOR THERAPEUTCS</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>28202V108</cusip>
    <value>1113648</value>
    <shrsOrPrnAmt>
      <sshPrnamt>2382644</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
    </shrsOrPrnAmt>
    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>2382644</Sole>
      <Shared>0</Shared>
      <None>0</None>
    </votingAuthority>
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  <infoTable>
    <nameOfIssuer>EXELIXIS INC</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>30161Q104</cusip>
    <value>335620</value>
    <shrsOrPrnAmt>
      <sshPrnamt>13990</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>9300</Sole>
      <Shared>0</Shared>
      <None>4690</None>
    </votingAuthority>
  </infoTable>
  <infoTable>
    <nameOfIssuer>EYEPOINT PHARMA</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>30233G209</cusip>
    <value>1875608</value>
    <shrsOrPrnAmt>
      <sshPrnamt>81160</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
    </shrsOrPrnAmt>
    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>77800</Sole>
      <Shared>0</Shared>
      <None>3360</None>
    </votingAuthority>
  </infoTable>
  <infoTable>
    <nameOfIssuer>4D MOLECULAR THERA</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>35104E100</cusip>
    <value>2887253</value>
    <shrsOrPrnAmt>
      <sshPrnamt>142510</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
    </shrsOrPrnAmt>
    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>0</Sole>
      <Shared>0</Shared>
      <None>142510</None>
    </votingAuthority>
  </infoTable>
  <infoTable>
    <nameOfIssuer>FUSION PHARMACEUTI</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>36118A100</cusip>
    <value>550624</value>
    <shrsOrPrnAmt>
      <sshPrnamt>57297</sshPrnamt>
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    <votingAuthority>
      <Sole>57297</Sole>
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      <None>0</None>
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    <nameOfIssuer>GILEAD SCIENCES INC</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>375558103</cusip>
    <value>3313714</value>
    <shrsOrPrnAmt>
      <sshPrnamt>40905</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>27000</Sole>
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      <None>13905</None>
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    <nameOfIssuer>GOODRX HLDGS INC</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>38246G108</cusip>
    <value>2438800</value>
    <shrsOrPrnAmt>
      <sshPrnamt>364000</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>364000</Sole>
      <Shared>0</Shared>
      <None>0</None>
    </votingAuthority>
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    <nameOfIssuer>GRAPHITE BIO INC</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>38870X104</cusip>
    <value>1157592</value>
    <shrsOrPrnAmt>
      <sshPrnamt>441829</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>413829</Sole>
      <Shared>0</Shared>
      <None>28000</None>
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    <nameOfIssuer>HALOZYME THERAPEUTIC</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>40637H109</cusip>
    <value>222869</value>
    <shrsOrPrnAmt>
      <sshPrnamt>6030</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>3900</Sole>
      <Shared>0</Shared>
      <None>2130</None>
    </votingAuthority>
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  <infoTable>
    <nameOfIssuer>HUMANA INC</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>444859102</cusip>
    <value>3765487</value>
    <shrsOrPrnAmt>
      <sshPrnamt>8225</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>8225</Sole>
      <Shared>0</Shared>
      <None>0</None>
    </votingAuthority>
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    <nameOfIssuer>ILLUMINA INC</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>452327109</cusip>
    <value>918984</value>
    <shrsOrPrnAmt>
      <sshPrnamt>6600</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>4370</Sole>
      <Shared>0</Shared>
      <None>2230</None>
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    <nameOfIssuer>IMMUNOGEN INC</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>45253H101</cusip>
    <value>530616</value>
    <shrsOrPrnAmt>
      <sshPrnamt>17896</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>11038</Sole>
      <Shared>0</Shared>
      <None>6858</None>
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    <nameOfIssuer>INCYTE CORPORATION</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>45337C102</cusip>
    <value>634493</value>
    <shrsOrPrnAmt>
      <sshPrnamt>10105</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>6680</Sole>
      <Shared>0</Shared>
      <None>3425</None>
    </votingAuthority>
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    <nameOfIssuer>INSMED INC</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>457669307</cusip>
    <value>428003</value>
    <shrsOrPrnAmt>
      <sshPrnamt>13811</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>9221</Sole>
      <Shared>0</Shared>
      <None>4590</None>
    </votingAuthority>
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  <infoTable>
    <nameOfIssuer>INSULET CORP</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>45784P101</cusip>
    <value>2809891</value>
    <shrsOrPrnAmt>
      <sshPrnamt>12950</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>12950</Sole>
      <Shared>0</Shared>
      <None>0</None>
    </votingAuthority>
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    <nameOfIssuer>INTELLIA THERAPEUT</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>45826J105</cusip>
    <value>283557</value>
    <shrsOrPrnAmt>
      <sshPrnamt>9300</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>6200</Sole>
      <Shared>0</Shared>
      <None>3100</None>
    </votingAuthority>
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  <infoTable>
    <nameOfIssuer>INTRA CELLULAR THERA</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>46116X101</cusip>
    <value>531420</value>
    <shrsOrPrnAmt>
      <sshPrnamt>7420</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>4900</Sole>
      <Shared>0</Shared>
      <None>2520</None>
    </votingAuthority>
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  <infoTable>
    <nameOfIssuer>IONIS PHARMACEUTICAL</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>462222100</cusip>
    <value>327823</value>
    <shrsOrPrnAmt>
      <sshPrnamt>6480</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>4300</Sole>
      <Shared>0</Shared>
      <None>2180</None>
    </votingAuthority>
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  <infoTable>
    <nameOfIssuer>IOVANCE BIOTHERAPEUT</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>462260100</cusip>
    <value>1616244</value>
    <shrsOrPrnAmt>
      <sshPrnamt>198800</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>198800</Sole>
      <Shared>0</Shared>
      <None>0</None>
    </votingAuthority>
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  <infoTable>
    <nameOfIssuer>IQVIA HOLDINGS INC</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>46266C105</cusip>
    <value>3840908</value>
    <shrsOrPrnAmt>
      <sshPrnamt>16600</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>16600</Sole>
      <Shared>0</Shared>
      <None>0</None>
    </votingAuthority>
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    <nameOfIssuer>ITEOS THERAPEUTICS</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>46565G104</cusip>
    <value>2409613</value>
    <shrsOrPrnAmt>
      <sshPrnamt>220056</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>0</Sole>
      <Shared>0</Shared>
      <None>220056</None>
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  <infoTable>
    <nameOfIssuer>JOHNSON &amp; JOHNSON</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>478160104</cusip>
    <value>8440449</value>
    <shrsOrPrnAmt>
      <sshPrnamt>53850</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>53850</Sole>
      <Shared>0</Shared>
      <None>0</None>
    </votingAuthority>
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  <infoTable>
    <nameOfIssuer>KARUNA THERAPEUTICS</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>48576A100</cusip>
    <value>707400</value>
    <shrsOrPrnAmt>
      <sshPrnamt>2235</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>1480</Sole>
      <Shared>0</Shared>
      <None>755</None>
    </votingAuthority>
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  <infoTable>
    <nameOfIssuer>LEGEND BIOTECH CORP</nameOfIssuer>
    <titleOfClass>SPN ADR</titleOfClass>
    <cusip>52490G102</cusip>
    <value>180510</value>
    <shrsOrPrnAmt>
      <sshPrnamt>3000</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>3000</Sole>
      <Shared>0</Shared>
      <None>0</None>
    </votingAuthority>
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  <infoTable>
    <nameOfIssuer>LILLY ELI &amp; CO</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>532457108</cusip>
    <value>15485270</value>
    <shrsOrPrnAmt>
      <sshPrnamt>26565</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>26565</Sole>
      <Shared>0</Shared>
      <None>0</None>
    </votingAuthority>
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  <infoTable>
    <nameOfIssuer>MADRIGAL PHARMACEUTI</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>558868105</cusip>
    <value>277887</value>
    <shrsOrPrnAmt>
      <sshPrnamt>1201</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>800</Sole>
      <Shared>0</Shared>
      <None>401</None>
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  <infoTable>
    <nameOfIssuer>MEDPACE HOLDINGS</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>58506Q109</cusip>
    <value>420253</value>
    <shrsOrPrnAmt>
      <sshPrnamt>1371</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>910</Sole>
      <Shared>0</Shared>
      <None>461</None>
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  <infoTable>
    <nameOfIssuer>MERCK &amp; CO INC</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>58933Y105</cusip>
    <value>8667090</value>
    <shrsOrPrnAmt>
      <sshPrnamt>79500</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>79500</Sole>
      <Shared>0</Shared>
      <None>0</None>
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    <nameOfIssuer>MINERALYS THERAPEUTI</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>603170101</cusip>
    <value>5208212</value>
    <shrsOrPrnAmt>
      <sshPrnamt>605606</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>596616</Sole>
      <Shared>0</Shared>
      <None>8990</None>
    </votingAuthority>
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  <infoTable>
    <nameOfIssuer>MIRATI THERAPEUTICS</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>60468T105</cusip>
    <value>380348</value>
    <shrsOrPrnAmt>
      <sshPrnamt>6474</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>4133</Sole>
      <Shared>0</Shared>
      <None>2341</None>
    </votingAuthority>
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  <infoTable>
    <nameOfIssuer>MODERNA INC</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>60770K107</cusip>
    <value>1601145</value>
    <shrsOrPrnAmt>
      <sshPrnamt>16100</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>10400</Sole>
      <Shared>0</Shared>
      <None>5700</None>
    </votingAuthority>
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  <infoTable>
    <nameOfIssuer>MOONLAKE IMMUNOTHERA</nameOfIssuer>
    <titleOfClass>CLASS A</titleOfClass>
    <cusip>61559X104</cusip>
    <value>1812002</value>
    <shrsOrPrnAmt>
      <sshPrnamt>30005</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>29034</Sole>
      <Shared>0</Shared>
      <None>971</None>
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  <infoTable>
    <nameOfIssuer>NEUROCRINE BIOSCIENC</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>64125C109</cusip>
    <value>585673</value>
    <shrsOrPrnAmt>
      <sshPrnamt>4445</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>2950</Sole>
      <Shared>0</Shared>
      <None>1495</None>
    </votingAuthority>
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  <infoTable>
    <nameOfIssuer>OLEMA PHARMACEUTICAL</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>68062P106</cusip>
    <value>269797</value>
    <shrsOrPrnAmt>
      <sshPrnamt>19230</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>12700</Sole>
      <Shared>0</Shared>
      <None>6530</None>
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  <infoTable>
    <nameOfIssuer>OPTION CARE HEALTH</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>68404L201</cusip>
    <value>2156160</value>
    <shrsOrPrnAmt>
      <sshPrnamt>64000</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>64000</Sole>
      <Shared>0</Shared>
      <None>0</None>
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  <infoTable>
    <nameOfIssuer>PMV PHARMACEUTICALS</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>69353Y103</cusip>
    <value>2126554</value>
    <shrsOrPrnAmt>
      <sshPrnamt>685985</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>0</Sole>
      <Shared>0</Shared>
      <None>685985</None>
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  <infoTable>
    <nameOfIssuer>PFIZER INC</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>717081103</cusip>
    <value>5452826</value>
    <shrsOrPrnAmt>
      <sshPrnamt>189400</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>189400</Sole>
      <Shared>0</Shared>
      <None>0</None>
    </votingAuthority>
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  <infoTable>
    <nameOfIssuer>PRIVIA HEALTH GROUP</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>74276R102</cusip>
    <value>2079839</value>
    <shrsOrPrnAmt>
      <sshPrnamt>90310</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>90310</Sole>
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      <None>0</None>
    </votingAuthority>
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  <infoTable>
    <nameOfIssuer>REGENERON PHARMCTCLS</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>75886F107</cusip>
    <value>3368242</value>
    <shrsOrPrnAmt>
      <sshPrnamt>3835</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>2520</Sole>
      <Shared>0</Shared>
      <None>1315</None>
    </votingAuthority>
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  <infoTable>
    <nameOfIssuer>REPLIMUNE GROUP INC</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>76029N106</cusip>
    <value>2574623</value>
    <shrsOrPrnAmt>
      <sshPrnamt>305412</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>0</Sole>
      <Shared>0</Shared>
      <None>305412</None>
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  <infoTable>
    <nameOfIssuer>REVOLUTION MEDICIN</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>76155X100</cusip>
    <value>393203</value>
    <shrsOrPrnAmt>
      <sshPrnamt>13710</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>9100</Sole>
      <Shared>0</Shared>
      <None>4610</None>
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  <infoTable>
    <nameOfIssuer>ROCKET PHARMACEUTICA</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>77313F106</cusip>
    <value>368032</value>
    <shrsOrPrnAmt>
      <sshPrnamt>12280</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>7700</Sole>
      <Shared>0</Shared>
      <None>4580</None>
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  <infoTable>
    <nameOfIssuer>SPDR SER TR</nameOfIssuer>
    <titleOfClass>S&amp;P BIOTECH</titleOfClass>
    <cusip>78464A870</cusip>
    <value>1824998</value>
    <shrsOrPrnAmt>
      <sshPrnamt>20439</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>0</Sole>
      <Shared>0</Shared>
      <None>20439</None>
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  <infoTable>
    <nameOfIssuer>SANOFI</nameOfIssuer>
    <titleOfClass>SPN ADR</titleOfClass>
    <cusip>80105N105</cusip>
    <value>700696</value>
    <shrsOrPrnAmt>
      <sshPrnamt>14090</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>8900</Sole>
      <Shared>0</Shared>
      <None>5190</None>
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  <infoTable>
    <nameOfIssuer>SAREPTA THERAPEUTICS</nameOfIssuer>
    <titleOfClass>COM</titleOfClass>
    <cusip>803607100</cusip>
    <value>2077199</value>
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      <Sole>337388</Sole>
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    <nameOfIssuer>STRUCTURE THERAPEU</nameOfIssuer>
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      <Sole>3400</Sole>
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      <None>0</None>
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    <value>78300</value>
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      <sshPrnamt>92060</sshPrnamt>
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      <None>4760</None>
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    <cusip>883556102</cusip>
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      <sshPrnamt>9015</sshPrnamt>
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      <Sole>9015</Sole>
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    <titleOfClass>COM</titleOfClass>
    <cusip>89422G107</cusip>
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      <sshPrnamt>274623</sshPrnamt>
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    <value>1317414</value>
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      <sshPrnamt>517648</sshPrnamt>
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    <votingAuthority>
      <Sole>517648</Sole>
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      <None>0</None>
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    <nameOfIssuer>UNITED THERAPEUTICS</nameOfIssuer>
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      <sshPrnamt>2815</sshPrnamt>
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      <Sole>1815</Sole>
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      <None>1000</None>
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      <sshPrnamt>18925</sshPrnamt>
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      <Sole>18925</Sole>
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      <None>0</None>
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    <titleOfClass>COM</titleOfClass>
    <cusip>92243G108</cusip>
    <value>505540</value>
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      <sshPrnamt>8050</sshPrnamt>
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      <Sole>5350</Sole>
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      <None>2700</None>
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    <titleOfClass>COM</titleOfClass>
    <cusip>92337C203</cusip>
    <value>1655082</value>
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      <sshPrnamt>203327</sshPrnamt>
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      <Sole>0</Sole>
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      <None>203327</None>
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    <nameOfIssuer>VERA THERAPEUTICS</nameOfIssuer>
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    <cusip>92337R101</cusip>
    <value>1909442</value>
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      <sshPrnamt>124151</sshPrnamt>
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    <votingAuthority>
      <Sole>117883</Sole>
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      <None>6268</None>
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    <titleOfClass>COM</titleOfClass>
    <cusip>92532F100</cusip>
    <value>3751119</value>
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      <sshPrnamt>9219</sshPrnamt>
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    <votingAuthority>
      <Sole>6069</Sole>
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      <None>3150</None>
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    <cusip>98887Q104</cusip>
    <value>109320</value>
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      <sshPrnamt>4000</sshPrnamt>
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    <investmentDiscretion>SOLE</investmentDiscretion>
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      <Sole>4000</Sole>
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      <None>0</None>
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    <titleOfClass>COM</titleOfClass>
    <cusip>98943L107</cusip>
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      <sshPrnamt>7355</sshPrnamt>
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      <Sole>0</Sole>
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      <None>7355</None>
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    <titleOfClass>SHS</titleOfClass>
    <cusip>G01767105</cusip>
    <value>425254</value>
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      <sshPrnamt>15330</sshPrnamt>
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      <Sole>10050</Sole>
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      <None>5280</None>
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    <cusip>G4705A100</cusip>
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      <sshPrnamt>10203</sshPrnamt>
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    <investmentDiscretion>SOLE</investmentDiscretion>
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      <Sole>9850</Sole>
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      <None>353</None>
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      <sshPrnamt>4094</sshPrnamt>
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    <votingAuthority>
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      <None>1394</None>
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      <None>0</None>
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      <sshPrnamt>46777</sshPrnamt>
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      <None>7070</None>
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    <nameOfIssuer>UNIQURE N.V.</nameOfIssuer>
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    <cusip>N90064101</cusip>
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      <sshPrnamt>292592</sshPrnamt>
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</informationTable>
