X0306 4 2014-01-24 0000946840 VIROPHARMA INC VPHM 0001273313 CLAYPOOL WILLIAM D MD 730 STOCKTON DRIVE EXTON PA 19341 1 Common Stock 2014-01-24 4 U 0 49000 50.00 D 0 D Non-qualified Stock Option (Right to Buy) 20.15 2014-01-24 4 D 0 10000 D 2007-02-20 2016-02-19 Common Stock 10000 0 D Non-qualified Stock Option (Right to Buy) 17.76 2014-01-24 4 D 0 10000 D 2008-02-26 2017-02-25 Common Stock 10000 0 D Non-qualified Stock Option (Right to Buy) 31.74 2014-01-24 4 D 0 15000 D 2013-02-24 2022-02-24 Common Stock 15000 0 D Stock Option (Right to Buy) 17.30 2014-01-24 4 D 0 15000 D 2012-02-21 2021-02-21 Common Stock 15000 0 D Stock Option (Right to Buy) 25.25 2014-01-24 4 D 0 15000 D 2014-02-22 2023-02-22 Common Stock 15000 0 D Restricted Stock Units 2014-01-24 4 D 0 4500 D Common Stock 4500 0 D The options vest in full one year from date of grant. This derivative security, regardless of whether otherwise previously vested, was canceled in connection with the merger of ViroPharma Incorporated with and into Shire Pharmaceutical Holdings Ireland Limited, effective as of January 24, 2014 in exchange for a cash payment representing, in the case of stock options, the difference between the per-share exercise price of the stock option and $50, and in the case of restricted stock units, $50 per share. Each restricted stock unit represents a contingent right to receive one share of VPHM common stock. The restricted stock unit vests in full one year from the date of grant. Vested shares will be delivered to the reporting person upon vesting. /s/ J. Peter Wolf, attorney-in-fact 2014-01-28