X0303 4 2011-03-03 0000946840 VIROPHARMA INC VPHM 0001273313 CLAYPOOL WILLIAM D MD 730 STOCKTON DRIVE EXTON PA 19341 1 Common Stock 2011-03-03 4 M 0 13641 2.94 A 73641 D Common Stock 2011-03-03 4 S 0 13641 18.25 D 60000 D Common Stock 2011-03-03 4 M 0 25000 3.00 A 85000 D Common Stock 2011-03-03 4 S 0 3900 18.25 D 81100 D Common Stock 2011-03-03 4 S 0 1000 18.255 D 80100 D Common Stock 2011-03-03 4 S 0 1300 18.26 D 78800 D Common Stock 2011-03-03 4 S 0 400 18.27 D 78400 D Common Stock 2011-03-03 4 S 0 2200 18.275 D 76200 D Common Stock 2011-03-03 4 S 0 5600 18.28 D 70600 D Common Stock 2011-03-03 4 S 0 900 18.285 D 69700 D Common Stock 2011-03-03 4 S 0 200 18.2875 D 69500 D Common Stock 2011-03-03 4 S 0 1800 18.29 D 67700 D Common Stock 2011-03-03 4 S 0 2600 18.30 D 65100 D Common Stock 2011-03-03 4 S 0 100 18.305 D 65000 D Common Stock 2011-03-03 4 S 0 100 18.307 D 64900 D Common Stock 2011-03-03 4 S 0 1000 18.31 D 63900 D Common Stock 2011-03-03 4 S 0 600 18.315 D 63300 D Common Stock 2011-03-03 4 S 0 100 18.317 D 63200 D Common Stock 2011-03-03 4 S 0 700 18.32 D 62500 D Common Stock 2011-03-03 4 S 0 300 18.325 D 62200 D Common Stock 2011-03-03 4 S 0 1200 18.33 D 61000 D Common Stock 2011-03-03 4 S 0 800 18.34 D 60200 D Common Stock 2011-03-03 4 S 0 200 18.35 D 60000 D Non-qualified Stock Option (Right to Buy) 2.94 2011-03-03 4 M 0 13641 0 D 2004-12-18 2013-12-18 Common Stock 13641 0 D Non-qualified Stock Option (Right to Buy) 3.00 2011-03-03 4 M 0 25000 0 D 2006-02-09 2015-02-08 Common Stock 25000 0 D The options vest in three equal annual installments beginning on the anniversary date from time of grant. The options vest in full one year from date of grant /s/ J. Peter Wolf, attorney-in-fact 2011-03-04