X0306 4 2013-03-05 0 0000831547 SPECTRUM PHARMACEUTICALS INC SPPI 0001273213 MAIDA ANTHONY E III 11500 S. EASTERN AVE. SUITE 240 HENDERSON NV 89052 1 0 0 0 Common Stock, $0.001 par value 2013-03-05 4 M 0 5000 3.92 A 12550 D Common Stock, $0.001 par value 2013-03-05 4 S 0 5000 11.4997 D 7550 D Stock Option Exercise (Right to Buy) 3.92 2013-03-05 4 M 0 5000 0.00 D 2020-07-01 Common Stock 5000 23300 D All sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on August 13, 2012. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $11.34 to $11.57, inclusive. The reporting person undertakes to provide to Spectrum Pharmaceuticals, Inc., any security holder of Spectrum Pharmaceuticals, Inc., or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote. The stock option, representing the right to purchase a total of 30,000 shares of common stock, was granted on July 1, 2010. The stock option became exercisable as to 7,500 shares on July 1, 2010, 7,500 shares on July 1, 2011 and 7,500 shares on July 1, 2012. 7,500 shares will become exercisable on July 1, 2013. /s/ Brett L. Scott, attorney-in-fact for Anthony E. Maida 2013-03-05