X0306 4 2014-08-14 0 0001571498 Epizyme, Inc. EPZM 0001270521 KOLLURI KRISHNA KITTU 1954 GREENSPRING DRIVE SUITE 600 TIMONIUM MD 21093 0 0 1 0 Common Stock 2014-08-14 4 J 0 1290000 0 D 4743240 I See Note 2 Common Stock 2014-08-14 4 J 0 12900 0 A 12900 I See Note 4 Common Stock 2014-08-14 4 J 0 12900 0 D 0 I See Note 4 Common Stock 2014-08-14 4 J 0 483 0 A 483 I See Note 7 Common Stock 2014-08-15 4 S 0 483 36.57 D 0 I See Note 7 Common Stock 2014-08-14 4 J 0 84 0 A 84 I See Note 9 Common Stock 2014-08-15 4 S 0 84 36.57 D 0 I See Note 9 Common Stock 2014-08-14 4 J 0 84 0 A 84 I See Note 11 Common Stock 2014-08-15 4 S 0 84 36.57 D 0 I See Note 11 Common Stock 406500 I See Note 12 New Enterprise Associates 13, L.P. ("NEA 13") made a pro rata distribution for no consideration of an aggregate of 1,290,000 shares of Common Stock of the Issuer, to its general partner and its limited partners on August 14, 2014. The Reporting Person is a director of NEA 13 GP, LTD, which is the sole general partner of NEA Partners 13, L.P. ("NEA Partners 13"). NEA Partners 13 is the sole general partner of NEA 13, which is the direct beneficial owner of the securities. The Reporting Person disclaims beneficial ownership, within the meaning of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise of such portion of the NEA 13 shares in which the Reporting Person has no pecuniary interest. NEA Partners 13 received 12,900 shares of Common Stock of the Issuer in the distribution by NEA 13 on August 14, 2014. The Reporting Person is a director of NEA 13 GP, LTD, which is the sole general partner of NEA Partners 13, the director beneficial owner of the shares of Common Stock of the Issuer. The Reporting Person disclaims beneficial ownership, within the meaning of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise of such portion of the NEA Partners 13 shares in which the Reporting Person has no pecuniary interest. NEA Partners 13 made a pro rata distribution for no consideration of an aggregate of 12,900 shares of Common Stock of the Issuer to its limited partners on August 14, 2014. The Kolluri Living Trust dated 11/5/99 (the "Kolluri Trust") received 483 shares of Common Stock of the Issuer in the distribution by NEA Partners 13 on August 14, 2014. The shares are held directly by the Kolluri Trust. The Reporting Person disclaims beneficial ownership within the meaning of Section 16 of the 1934 Act, as amended, of the shares held by the Kolluri Trust, except to the extent of his pecuniary interest therein. The Krishna S. Kolluri and Vanita S. Kolluri, as Trustees of the Ishaan S. Kolluri GST Exempt Trust under the Kolluri 2012 Trust Agreement dated November 16, 2012 (the "Ishaan S. Kolluri Trust") received 84 shares of Common Stock of the Issuer in the distribution by NEA Partners 13 on August 14, 2014. The shares are held directly by the Ishaan S. Kolluri Trust. The Reporting Person disclaims beneficial ownership within the meaning of Section 16 of the 1934 Act, as amended, of the shares held by the Ishaan S. Kolluri Trust, except to the extent of his pecuniary interest therein. The Krishna S. Kolluri and Vanita S. Kolluri, as Trustee of the Raina V. Kolluri GST Exempt Trust under the Kolluri 2012 Trust Agreement dated November 16, 2012 (the "Raina V. Kolluri Trust") received 84 shares of Common Stock of the Issuer in the distribution by NEA Partners 13 on August 14, 2014. The shares are held directly by the Raina V. Kolluri Trust. The Reporting Person disclaims beneficial ownership within the meaning of Section 16 of the 1934 Act, as amended, of the shares held by the Raina V. Kolluri Trust, except to the extent of his pecuniary interest therein. The Reporting Person is a director of NEA 13 GP, LTD, which is the sole general partner of NEA Partners 13. NEA Partners 13 is the sole general partner of NEA 13, which is the sole member of Growth Equity Opportunities Fund II, LLC ("GEO II"), the direct beneficial owner of the securities. The Reporting Person disclaims beneficial ownership within the meaning of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise of such portion of the GEO II shares in which the Reporting Person has no pecuniary interest. /s/ Sasha Keough, attorney-in-fact 2014-08-18