Stock Compensation (Tables)

6 Months Ended

Jun. 30, 2022

Stock Compensation

Schedule of Share Based Compensation Stock Options Activities

The following table summarizes stock option activity during the six months ended June 30, 2022 (under both the 2012 Plan and the 2022 Plan):

				Weighted
				Average
	Number	Weighted		Remaining	Aggregate
	of Options	Average		Contractual	Intrinsic Value
	(in thousands)	Exercise Price		Term (years)	(in thousands)
Outstanding at December 31, 2021	2,252	$	50.28	7.2	$	408
Granted	467	$	15.20	—	$	—
Exercised	—	$	—	—	$	—
Cancelled/forfeited	(117)	$	28.14	—	$	—
Expired	(96)	$	104.36	—	$	—
Outstanding at June 30, 2022	2,506	$	42.70	7.3	$	—
Expected to vest	1,389	$	21.95	8.4	$	—
Exercisable	1,117	$	68.52	5.9	$	—

Schedule of Share Based Compensation Arrangement By Share Based Payment Award Grants in Period Fair Value Assumptions

The Company estimated the fair value of stock options granted in the periods presented utilizing a Black-Scholes option-pricing model utilizing the following assumptions:

	Six Months Ended June 30,
	2022		2021
Volatility	66.4 - 67.7	%	65.2 - 67.7	%
Expected term (in years)	5.5 - 6.0		5.5 - 6.0
Risk-free rate	1.3 - 2.8	%	0.4 - 0.9	%
Expected dividend yield	—	%	—	%

Schedule of Share-based Compensation, Restricted Stock Units Award Activity

The following table summarizes the aggregate RSU, RSA and PRSU activity during the six months ended June 30, 2022:

		Weighted
	Number of	Average Grant Date
	Awards	Fair Value
	(in thousands)
Non-vested awards at December 31, 2021	968	$	39.58
Granted	779	$	15.76
Vested	(157)	$	28.72
Forfeited	(143)	$	43.44
Non-vested awards at June 30, 2022	1,447	$	27.55

Schedule of Stock Based Compensation Expense

Stock-based compensation expense has been reported in the Company’s condensed consolidated statements of operations as follows:

	Three Months Ended June 30,				Six Months Ended June 30,
	2022		2021		2022		2021
					(in thousands)
Selling, general and administrative	$	3,980	$	5,678	$	8,074	$	10,518
Research and development		1,401		1,148		2,796		3,175
Restructuring		—		—		—		—
Total stock-based compensation	$	5,381	$	6,826	$	10,870	$	13,693