Condensed Consolidated Statements of Operations - USD ($) shares in Thousands, $ in Thousands	3 Months Ended
	Mar. 31, 2020	Mar. 31, 2019
Revenue	$ 72,652	$ 52,252
Operating expenses:
Cost of sales	852	574
Selling, general and administrative	98,558	77,227
Research and development	56,687	58,396
Total operating expenses	156,097	136,197
Operating loss	(83,445)	(83,945)
Other income (expense):
Interest expense	(11,777)	(7,839)
Other income, net	2,239	1,514
Total other (expense), net	(9,538)	(6,325)
Net loss	$ (92,983)	$ (90,270)
Net loss per common and potential common share:
Basic and diluted	$ (2.86)	$ (3.03)
Weighted average common and potential common shares outstanding:
Basic and diluted	32,561	29,760
Product [Member]
Revenue	$ 72,652	$ 51,847
License [Member]
Revenue		$ 405