Stock Compensation (Tables)

3 Months Ended

Mar. 31, 2020

Stock Compensation [Abstract]

Schedule of Share Based Compensation Stock Options Activities

The following table summarizes stock option activity during the three months ended March 31, 2020:

				Weighted
				Average
	Number	Weighted		Remaining	Aggregate
	of Options	Average		Contractual	Intrinsic Value
	(in thousands)	Exercise Price		Term (years)	(in thousands)
Outstanding at December 31, 2019	1,981	$	99.87	7.4	$	65,662
Granted	557	$	99.94	—	$	—
Exercised	(9)	$	47.78	—	$	—
Cancelled/forfeited	(63)	$	97.85	—	$	—
Expired	(20)	$	198.78	—	$	—
Outstanding at March 31, 2020	2,446	$	99.32	7.7	$	6,106
Expected to vest	1,256	$	92.39	9.0	$	1,005
Exercisable	1,190	$	106.62	6.4	$	5,101

Schedule of Share Based Compensation Arrangement By Share Based Payment Award Grants in Period Fair Value Assumptions

The Company estimated the fair value of stock options granted in the periods presented utilizing a Black-Scholes option-pricing model utilizing the following assumptions:

	Three Months Ended March 31,
	2020		2019
Volatility	61.9 - 87.1	%	87.0 - 87.2	%
Expected term (in years)	6.0		6.0
Risk-free rate	0.9 - 1.7	%	2.5 - 2.9	%
Expected dividend yield	—	%	—	%

Schedule of Share-based Compensation, Restricted Stock Units Award Activity

The following table summarizes the aggregate RSU, restricted stock award (“RSA”), PRSU and performance restricted share award (“PRSA”) activity during the three months ended March 31, 2020:

		Weighted
	Number of	Average Grant Date
	Awards	Fair Value
	(in thousands)
Non-vested awards at December 31, 2019	709	$	88.39
Granted	399	$	102.82
Vested	(104)	$	74.75
Forfeited	(43)	$	94.43
Non-vested awards at March 31, 2020	961	$	95.58

Schedule of Stock Based Compensation Expense

Stock-based compensation expense has been reported in the Company’s condensed consolidated statements of operations as follows:

	Three Months Ended March 31,
	2020		2019
	(in thousands)
Selling, general and administrative	$	9,723	$	11,331
Research and development		2,750		3,566
Total stock-based compensation	$	12,473	$	14,897