Condensed Consolidated Statements of Cash Flows - USD ($) $ in Thousands	9 Months Ended
Sep. 30, 2019	Sep. 30, 2018
Cash flows from operating activities:
Net loss	$ (246,523)	$ (221,237)
Adjustments to reconcile net loss to net cash used in operating activities:
Stock-based compensation	42,809	38,415
(Accretion) amortization of (discount) premium on investment debt securities	(595)	266
Amortization of deferred financing costs	1,529	1,144
Depreciation	2,839	3,551
Non-cash operating lease cost	3,974
Gain on lease termination	(1,995)
Loss on the disposal of fixed assets	2,682	1,331
Accretion of debt discount	15,051	10,412
Unrealized gain on investments		(119)
Changes in operating assets:
Prepaid expenses and other current assets	(3,320)	(856)
Accounts receivable	(7,128)	(5,579)
Inventory	(2,240)	(3,995)
Security deposits	1,018	7,138
Other assets	(19,489)
Changes in operating liabilities:
Accounts payable, accrued expenses and other current liabilities	33,990	(11,719)
Operating lease liabilities	(5,019)
Long-term other liabilities	9,516	(1,300)
Interest payable	(2,012)	(3,738)
Deferred revenue	(1,216)	(1,616)
Net cash used in operating activities	(176,129)	(187,902)
Cash flows from investing activities:
Purchases of investment debt securities	(560,733)	(378,261)
Sales and maturities of investment debt securities	306,898	293,307
Purchases of equipment, leasehold improvements, and furniture and fixtures	(1,041)	(45)
Net cash used by investing activities	(254,876)	(84,999)
Cash flows from financing activities:
Proceeds from issuance of 2026 Convertible Notes, net of issuance costs	223,424
Proceeds from issuance of common stock, net of issuance costs	227,180	261,362
Proceeds from exercise of options, net	2,511	3,201
Payments of employee withholding taxes related to stock-based awards	(1,476)	(1,458)
Net cash provided by financing activities	451,639	263,105
Effect of exchange rate changes	(505)	(835)
Net increase (decrease) in cash and cash equivalents	20,129	(10,631)
Cash and cash equivalents - beginning of period	43,248	70,013
Cash and cash equivalents - end of period	$ 63,377	$ 59,382

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