Condensed Consolidated Statements of Operations - USD ($) shares in Thousands, $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2019	Sep. 30, 2018	Sep. 30, 2019	Sep. 30, 2018
Revenue	$ 61,950	$ 46,986	$ 180,502	$ 126,524
Operating expenses:
Cost of sales	487	519	1,738	1,512
Selling, general and administrative	76,828	56,812	223,738	184,503
Research and development	60,168	47,941	178,163	144,028
Total operating expenses	137,483	105,272	403,639	330,043
Operating loss	(75,533)	(58,286)	(223,137)	(203,519)
Other income (expense):
Interest expense	(11,795)	(7,671)	(29,518)	(22,769)
Other income, net	2,495	1,503	6,132	5,051
Total other income (expense)	(9,300)	(6,168)	(23,386)	(17,718)
Net loss	$ (84,833)	$ (64,454)	$ (246,523)	$ (221,237)
Net loss per common and potential common share:
Basic and diluted	$ (2.59)	$ (2.18)	$ (7.88)	$ (7.89)
Weighted average common and potential common shares outstanding:
Basic and diluted	32,717	29,615	31,275	28,057
Product [Member]
Revenue	$ 61,545	$ 46,581	$ 179,286	$ 124,908
License [Member]
Revenue	$ 405	$ 405	$ 1,216	$ 1,616