Condensed Consolidated Statements of Operations - USD ($) shares in Thousands, $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2019	Jun. 30, 2018	Jun. 30, 2019	Jun. 30, 2018
Revenue	$ 66,300	$ 43,575	$ 118,552	$ 79,538
Operating expenses:
Cost of sales	677	713	1,251	993
Selling, general and administrative	69,683	65,224	146,910	127,691
Research and development	59,599	47,415	117,995	96,087
Total operating expenses	129,959	113,352	266,156	224,771
Operating loss	(63,659)	(69,777)	(147,604)	(145,233)
Other income (expense):
Interest expense	(9,884)	(7,589)	(17,723)	(15,098)
Other income, net	2,123	2,173	3,637	3,548
Total other income (expense)	(7,761)	(5,416)	(14,086)	(11,550)
Net loss	$ (71,420)	$ (75,193)	$ (161,690)	$ (156,783)
Net loss per common and potential common share:
Basic and diluted	$ (2.28)	$ (2.58)	$ (5.29)	$ (5.75)
Weighted average common and potential common shares outstanding:
Basic and diluted	31,316	29,199	30,542	27,265
Product [Member]
Revenue	$ 65,894	$ 43,169	$ 117,741	$ 78,327
License [Member]
Revenue	$ 406	$ 406	$ 811	$ 1,211