Condensed Consolidated Balance Sheets - USD ($) $ in Thousands	Mar. 31, 2020	Dec. 31, 2019
Current assets:
Cash and cash equivalents	$ 196,235	$ 215,229
Short-term investments	166,661	214,054
Restricted cash	4,274	3,421
Trade and other receivables, net	7,410	13,547
Unbilled - collaboration and license revenue	3,408	3,783
Inventories	3,576	4,101
Prepaid and other current assets	10,374	7,998
Total current assets	391,938	462,133
Property and equipment, net	4,872	4,264
Operating lease right-of-use assets	11,112	12,064
Inventories, noncurrent portion	70,439	56,096
Long-term investments	31,164	36,961
Prepaid and other long-term assets	3,781	6,965
Total assets	513,306	578,483
Current liabilities:
Accounts payable	13,455	12,739
Accrued research and development	17,230	19,249
Accrued and other liabilities	39,920	49,773
Deferred revenue, current portion	1,188	1,623
Current portion of notes payable and long-term royalty-based debt	8,706	19,034
Total current liabilities	80,499	102,418
Notes payable, less current portion	46,269	43,100
Long term royalty-based debt, less current portion	171,237	162,897
Long term debt	118,400	118,096
Long term obligation to collaborator, less current portion	5,734	5,060
Deferred revenue, long-term	4,296	4,352
Long-term portion of lease liabilities	7,786	8,850
Other long-term liabilities	7,052	3,885
Total liabilities	441,273	448,658
Stockholders’ equity:
Preferred stock, $0.001 par value, 5,000 shares authorized; no shares issued and outstanding	0	0
Common stock, $0.001 par value, 150,000 shares authorized at March 31, 2020 and December 31, 2019; 78,484 shares and 77,925, shares issued and outstanding at March 31, 2020 and December 31, 2019, respectively	80	80
Additional paid-in capital	1,956,263	1,946,077
Accumulated deficit	(1,885,138)	(1,816,367)
Accumulated other comprehensive income	828	35
Total stockholders’ equity	72,033	129,825
Total liabilities and stockholders’ equity	$ 513,306	$ 578,483