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Stock Based Compensation (Tables)

6 Months Ended

Jun. 30, 2019

Disclosure Of Compensation Related Costs Sharebased Payments [Abstract]

The following table summarizes stock option activity under our 2013 Equity Incentive Plan (the “2013 Plan”) and an Inducement Plan, and related information during the six months ended June 30, 2019 and 2018:

	Shares
	Subject to			Weighted-
	Outstanding			Average Exercise
	Options			Price Per Share
Balance at December 31, 2018		7,507,690		$	33.25
Options granted		1,716,643			27.71
Options exercised		(632,254	)		20.79
Options canceled		(678,423	)		39.19
Balance at June 30, 2019		7,913,656		$	32.54

Summary of PSO Activities

The following table summarizes PSO activities under our 2013 Plan and related information during the six months ended June 30, 2019

	Shares
	Subject to			Weighted-
	Outstanding			Average Exercise
	PSOs			Price Per Share
Balance at December 31, 2018		143,335		$	23.76
Options granted		490,986			33.29
Options exercised		(26,667	)		23.76
Options canceled		(11,250	)		33.29
Balance at June 30, 2019		596,404		$	31.43

Summary of RSU Activity

The following table summarizes RSU activity under our 2013 Plan and Inducement Plan, and related information during the six months ended June 30, 2019:

	Shares
	Subject to			Weighted-
	Outstanding			Average Grant Date
	RSUs			Fair Value Per Share
Balance at December 31, 2018		979,278		$	34.00
RSUs granted		638,970			27.86
RSUs released		(314,311	)		35.29
RSUs canceled		(76,836	)		35.77
Balance at June 30, 2019		1,227,101		$	30.36

Summary of PSU Activity

The following table summarizes PSU activity under our 2013 Plan and related information during the six months ended June 30, 2019:

	Subject to			Weighted-
	Outstanding			Average Grant Date
	PSUs			Fair Value Per Share
Balance at December 31, 2018		153,503		$	29.85
PSUs granted		—			—
PSUs released		(52,670	)		28.29
PSUs canceled		(87,708	)		30.36
Balance at June 30, 2019		13,125		$	32.66

Classification of Stock-Based Compensation Expense

The table below sets forth the functional classification of stock-based compensation expense for the periods presented (in thousands):

	Three Months Ended June 30,					Six Months Ended June 30,
	2019			2018		2019			2018
Research and development	$	3,811		$	5,320	$	13,706		$	9,772
Selling, general and administrative		8,442			7,894		16,441			14,422
Stock-based compensation expense included in total expenses	$	12,253		$	13,214	$	30,147		$	24,194

Capitalized stock-based compensation costs	$	(116	)	$	-	$	(358	)	$	-